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Methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate hydrobromide

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Identification
Molecular formula
C9H14BrNO2
CAS number
16000-44-7
IUPAC name
methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide
State
State

At room temperature, the compound is found as a crystalline solid, which is typical for many hydrobromide salts. It remains stable under normal laboratory conditions, emphasizing its solid state at ambient temperatures.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
130.00
Boiling point (Kelvin)
403.15
General information
Molecular weight
236.11g/mol
Molar mass
236.1050g/mol
Density
1.3200g/cm3
Appearence

The compound methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate; hydrobromide typically appears as a white or off-white crystalline powder. The crystalline nature is evident from the granular texture, and it is generally odorless.

Comment on solubility

Solubility of Methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate Hydrobromide

The solubility of methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate hydrobromide presents interesting attributes influenced by its chemical structure.

General Characteristics

Generally, compounds containing a pyridine ring and a hydrobromide salt exhibit the following solubility tendencies:

  • High solubility in polar solvents such as water due to ionic interactions.
  • Moderate to low solubility in non-polar organic solvents which can be attributed to its zwitterionic nature.

Factors Affecting Solubility

Several factors can affect the solubility of this specific compound:

  1. Ionic Nature: The presence of the bromide ion enhances solubility in aqueous environments.
  2. Temperature: Increasing temperature generally increases solubility for most salts.
  3. pH levels: The solubility can vary with changes in the pH of the solution, especially if it leads to the formation of additional protonated or deprotonated species.

In summary, methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate hydrobromide is likely to be soluble in water, owing to the hydrophilic nature of its hydrobromide form, while being less soluble in organic, non-polar solvents. Understanding these solubility properties is crucial for applications in various fields including pharmaceuticals and synthetic chemistry.

Interesting facts

Interesting Facts about Methyl 1-Methyl-3,6-Dihydro-2H-Pyridine-5-Carboxylate Hydrobromide

Methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate hydrobromide is a fascinating compound that offers a glimpse into the intricate world of pyridine derivatives and their potential applications. Here are some key points of interest:

  • Pyridine Family: This compound belongs to the pyridine family, which is known for its aromatic properties and presence in a variety of natural and synthetic compounds. Pyridine derivatives often exhibit interesting biological activities.
  • Medicinal Potential: Compounds similar to methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate have been investigated for their potential as pharmaceutical agents. They may possess anti-inflammatory, analgesic, or anti-cancer properties.
  • Synthesis: The synthesis of this compound typically involves multiple steps, showcasing the complexity and creativity involved in organic chemistry. Understanding the reaction mechanisms can provide insights into designing new compounds with desirable properties.
  • Versatility: The carboxylate functional group in the structure makes it a versatile candidate for various chemical reactions, including esterification and substitution reactions. This can lead to the development of new derivatives with tailored functionalities.
  • Hydrobromide Salt Formation: The formation of the hydrobromide salt is significant for enhancing the solubility and stability of the compound, especially in pharmaceutical formulations. The salt form is often preferred for improving bioavailability.

In summary, methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate hydrobromide not only represents a unique structure but also embodies the bridging of organic chemistry and medicinal applications. As researchers delve deeper, compounds like these could unlock new therapeutic avenues and enhance our understanding of chemical interactions.

Synonyms
Arecoline hydrobromide
300-08-3
ARECOLINE HBr
Taeniolin
Arecoline bromide
Arekolinhydrobromid
Methyl 1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide
Arekolinhydrobromid [German]
Arecoline (hydrobromide)
EINECS 206-087-3
Arecoline hydrobromide [NF]
MFCD00039041
NSC 31750
NSC-31750
UNII-24S79B9CX7
24S79B9CX7
3-Pyridinecarboxylicacid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide
Methyl N-methyl-1,2,5,6-tetrahydronicotinate hydrobromide
N-Methyltetrahydronicotinic acid methyl ester hydrobromide
Methyl 1,2,5,6-tetrahydro-1-methylnicotinate, hydrobromide
DTXSID9075379
methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate,hydrobromide
ARECOLINE HYDROBROMIDE [MI]
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide
NICOTINIC ACID, 1,2,5,6-TETRAHYDRO-1-METHYL-, METHYL ESTER, HYDROBROMIDE
MLS000028840
NSC31750
SR-01000075307
SMR000058258
Esterase
Prestwick_958
methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide
methyl 1,2,5,6-tetrahydro-1-methylnicotinate hydrobromide
methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate hydrobromide
MLS002222282
ARECOLINE, HYDROBROMIDE
SCHEMBL527735
SPECTRUM1500680
CHEMBL449209
DTXCID6038112
MSK40378H
CHEBI:233150
HMS1569A06
HMS1921C10
Pharmakon1600-01500680
BCP02923
HY-B0489
Tox21_500049
CCG-38354
NSC757418
s2614
AKOS009031332
AC-8048
BCP9000314
FA17972
LP00049
NSC-757418
PS-7647
WLN: T6N CUTJ A1 CVO1 & GH
NCGC00093563-01
NCGC00093563-02
NCGC00093563-03
NCGC00093563-04
NCGC00093563-05
NCGC00093563-06
NCGC00260734-01
SY057191
BCP0726000295
A0523
EU-0100049
NS00079747
SW197045-3
EN300-21253
A 6134
A10820
SR-01000075307-1
SR-01000075307-3
SR-01000075307-8
Q27253878
SR-01000075307-10
SR-01000075307-11
Methyl N-methyl-1,5,6-tetrahydronicotinate hydrobromide
Z104494834
Arecoline hydrobromide, VETRANAL(TM), analytical standard
Methyl 1,5,6-tetrahydro-1-methylnicotinate, hydrobromide
Nicotinic acid,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide
1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester hydrobromide
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (9CI)
3-Pyridinecarboxylic acid,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide
1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid methyl ester hydrobromide;1-Methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic ac id methyl ester hydrobromide;Arecaidine methyl ester hydrobromide;METHYL 1,2,5,6-TETRAHYDRO-1-METHYL-3-PYRIDINECARBOXY
206-087-3