Skip to main content

Methyl prednisolone acetate

ADVERTISEMENT
Identification
Molecular formula
C24H32O6
CAS number
53-36-1
IUPAC name
methyl (1R,2S,4aR,8R)-7-[2-[2-(dimethylamino)ethoxy]-2-oxo-ethylidene]-2-hydroxy-1,4a,8-trimethyl-9-oxo-2,3,4,4b,5,6,8,8a,10,10a-decahydrophenanthrene-1-carboxylate
State
State

At room temperature, methyl prednisolone acetate is typically a solid. It comes in a crystalline powder form, commonly used in pharmaceuticals for its glucocorticoid activity.

Melting point (Celsius)
217.00
Melting point (Kelvin)
490.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
402.47g/mol
Molar mass
402.4710g/mol
Density
1.2700g/cm3
Appearence

Methyl prednisolone acetate is a white to practically white crystalline powder. It is very faint in odor and has a bitter taste. Under a microscope, it may appear as irregularly shaped particles with smooth surfaces.

Comment on solubility

Solubility of Methyl (1R,2S,4aR,8R)-7-[2-[2-(dimethylamino)ethoxy]-2-oxo-ethylidene]-2-hydroxy-1,4a,8-trimethyl-9-oxo-2,3,4,4b,5,6,8,8a,10,10a-decahydrophenanthrene-1-carboxylate

The solubility of this complex organic compound is influenced by several key factors related to its molecular structure. Here are some prominent aspects to consider:

  • Polarity: The presence of polar functional groups, such as the hydroxyl group and the dimethylamino group, typically increases solubility in polar solvents like water.
  • Hydrophobic Regions: The hydrocarbon parts of the molecule suggest that it may also exhibit hydrophobic characteristics, which could impact its solubility in nonpolar solvents.
  • Hydrogen Bonding: The ability of the molecule to engage in hydrogen bonding can enhance its interaction with solvents, thereby affecting solubility.
  • Overall Structure: The bulky phenanthrene moiety may lead to steric hindrance, possibly resulting in lower solubility due to the challenges in fitting into solvent molecules.

In conclusion, the solubility of methyl (1R,2S,4aR,8R)-7-[2-[2-(dimethylamino)ethoxy]-2-oxo-ethylidene]-2-hydroxy-1,4a,8-trimethyl-9-oxo-2,3,4,4b,5,6,8,8a,10,10a-decahydrophenanthrene-1-carboxylate is likely variable. It is expected to be soluble in polar environments due to its functional groups, yet the substantial aromatic and hydrophobic characteristics may restrain its solubility. Thus, understanding the intricate balance between these properties is crucial for predicting its behavior in different solvent systems.

Interesting facts

Interesting Facts about Methyl (1R,2S,4aR,8R)-7-[2-[2-(dimethylamino)ethoxy]-2-oxo-ethylidene]-2-hydroxy-1,4a,8-trimethyl-9-oxo-2,3,4,4b,5,6,8,8a,10,10a-decahydrophenanthrene-1-carboxylate

This compound, often referred to in the context of its potential therapeutic applications, showcases the intricate relationship between chemical structure and biological activity. Here are some fascinating insights:

  • Complex Structure: The compound exhibits a highly elaborate structure, featuring multiple stereocenters and functional groups that contribute to its unique properties.
  • Potential Applications: Its derivatives could play a significant role in medicinal chemistry, particularly in the fields of antitumor and anti-inflammatory therapies.
  • Structural Variability: The presence of dimethylamino and ethoxy groups indicates potential for significant steric and electronic effects on its reactivity and biological interactions.
  • Synthetic Challenges: The synthesis of such complex molecules often requires advanced techniques in organic synthesis, underscoring the importance of creativity and innovation in synthetic methodologies.
  • Natural Product Inspiration: Structures like this one often mimic natural products, highlighting how many drugs are inspired by nature's own chemistry.
  • Research Interest: The compound is a subject of ongoing research, as scientists aim to optimize its properties for enhanced efficacy and reduced side effects.

As a scientist studying this compound, one could be fascinated by the interplay of its delicate balance between structure and function, making it an excellent candidate for further investigation in the field of drug design. Its complex architecture serves as a reminder of the beauty and intricacy inherent in chemical compounds, inviting chemists and researchers alike to explore its potential.