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Erythromycin Ethylsuccinate

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Identification
Molecular formula
C43H75NO16
CAS number
1264-62-6
IUPAC name
methyl (1R,9R,10S,11R,12R,19R)-11-[2-(dimethylamino)acetyl]oxy-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid
State
State

At room temperature, erythromycin ethylsuccinate is generally in a solid state, often formulated into tablets, capsules, or suspensions for medicinal use.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
511.70
Boiling point (Kelvin)
784.85
General information
Molecular weight
862.06g/mol
Molar mass
862.0630g/mol
Density
1.2845g/cm3
Appearence

Erythromycin ethylsuccinate appears as a white to off-white crystalline powder. It is odourless or has a faint characteristic odour.

Comment on solubility

Solubility of Methyl Compound

The solubility of methyl (1R,9R,10S,11R,12R,19R)-11-[2-(dimethylamino)acetyl]oxy-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate can be intricate due to its complex structure and functional groups.

  • Polar vs. Nonpolar: Compounds with significant polar functional groups tend to have higher water solubility.
  • Hydrogen Bonding: The presence of hydroxyl (-OH) and dimethylamino groups suggests potential hydrogen bonding with water, possibly enhancing solubility.
  • Hydrophobic Interactions: Large hydrophobic moieties can counteract solubility, leading to poor water solubility despite polar interactions.

Given the presence of multiple functional groups and overall molecular complexity, this compound may exhibit variable solubility depending on solvent choice and temperature. Typical trends to consider include:

  1. In Hydrophilic Solvents: It may dissolve moderately well due to polar interactions.
  2. In Organic Solvents: Stronger solubility might be observed in organic solvents (e.g., ethanol, acetone) due to hydrophobic characteristics.

To conclude, the solubility profile of this compound will likely exhibit a balance between its polar and nonpolar characteristics, which makes understanding its solubility behavior essential for practical applications.

Interesting facts

Methyl (1R,9R,10S,11R,12R,19R)-11-[2-(dimethylamino)acetyl]oxy-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate; sulfuric acid

This compound represents a fascinating intersection of organic chemistry and pharmacology. Its complex structure indicates a high level of molecular intricacy which often correlates with biological activity. Here are a few intriguing points about this compound:

  • Multifunctionality: The presence of various functional groups, such as dimethylamino and carboxylate moieties, suggests versatility in chemical reactions and potential for diverse applications in medicinal chemistry.
  • Structural Organization: With multiple fused rings and stereocenters, the compound displays chirality which can greatly influence its pharmacokinetic and pharmacodynamic properties.
  • Potential Therapeutic Uses: Compounds with similar complex structures are often studied for their efficacy in treating conditions such as cancer, infectious diseases, or as anti-inflammatory agents, making it a candidate worth exploring.
  • Inspiration from Nature: Many synthetic compounds take inspiration from naturally occurring substances, such as alkaloids or terpenoids. This compound prompts a close look at the possible natural analogs that could provide insight into its synthesis and mechanism of action.

As one delves deeper into the interpretations of this compound’s structure and properties, it becomes increasingly clear that each element plays a pivotal role in the overall function. The intricate design requires not just a scientific approach but also a creative flair, emphasizing the beauty of chemistry in transforming complex ideas into tangible realities.

In the words of renowned chemist Linus Pauling, “The best way to get a good idea is to have a lot of ideas.” This compound certainly encapsulates the complexity and innovation that can emerge from relentless curiosity in the world of chemical science!