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Roxithromycin

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Identification
Molecular formula
C41H76N2O15
CAS number
80214-83-1
IUPAC name
methyl (1R,9R,10S,11R,12R,19R)-11-[2-(dimethylamino)acetyl]oxy-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
State
State
Roxithromycin is typically found as a solid at room temperature. It is commonly provided in powdered form for reconstitution and tablet formulation.
Melting point (Celsius)
113.00
Melting point (Kelvin)
386.15
Boiling point (Celsius)
875.00
Boiling point (Kelvin)
1 148.15
General information
Molecular weight
837.04g/mol
Molar mass
837.0440g/mol
Density
1.3400g/cm3
Appearence
Roxithromycin is a white to off-white crystalline powder. It is practically insoluble in water and freely soluble in acetone, chloroform, and methylene chloride.
Comment on solubility

Solubility of Methyl (1R,9R,10S,11R,12R,19R)-11-[2-(dimethylamino)acetyl]oxy-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

The solubility of the complex compound methyl (1R,9R,10S,11R,12R,19R)-11-[2-(dimethylamino)acetyl]oxy-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate can be influenced by various factors:

  • Polarity: The presence of polar functional groups, such as dimethylamino and carboxylate, suggests potential solubility in polar solvents like water.
  • Molecular Structure: The intricate structure, characterized by multiple rings and substituents, may hinder solubility in common solvents.
  • Hydrogen Bonding: The compound may engage in hydrogen bonding, which can enhance solubility in specific solvents.
  • Solvent Effects: Assessing solubility often varies with the choice of solvent; the compound may exhibit different solubility characteristics in ethanol, dimethyl sulfoxide, or acetone.

Due to its complex nature, it’s essential to experiment with various solvents to determine its solubility profile accurately. As with many biological and synthetic compounds, solubility can play a crucial role in its bioavailability and potential applications.

Interesting facts

Interesting Facts about Methyl (1R,9R,10S,11R,12R,19R)-11-[2-(dimethylamino)acetyl]oxy-12-ethyl-4-[(13S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate

This complex compound showcases the intricate world of organic chemistry and molecular design. Its structure features multiple functional groups and stereocenters that contribute to its unique properties, making it an interesting subject of study for chemists. Here are some fascinating aspects:

  • Complex Structure: The compound contains multiple rings and stereogenic centers, indicating a high level of structural complexity that is often associated with biologically active molecules.
  • Biological Relevance: Compounds of this type often exhibit significant biological activity. Researchers frequently investigate their pharmacological properties due to their potential as therapeutic agents.
  • Dimethylamino Functional Group: The presence of a dimethylamino group is common in pharmaceuticals, often enhancing solubility and biological activity.
  • Tetracyclic Framework: The tetracyclic structure may play a crucial role in the compound's interaction with biological targets, such as proteins and enzymes.
  • Potential Applications: This type of compound may have applications in drug development, particularly in areas related to cancer treatment, anti-inflammatory agents, and other therapeutic strategies.

In the words of a chemist, "The beauty of organic chemistry lies not just in the compounds we synthesize, but in the stories they tell about their interactions and functions within living systems." Understanding such elaborate compounds can not only expand our knowledge of chemical behavior but also pave the way for innovative solutions to complex health challenges.

Synonyms
NS00126982