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Amfenac methyl ester

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Identification
Molecular formula
C20H18ClNO4
CAS number
68334-33-0
IUPAC name
methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate
State
State

At room temperature, it is a solid compound, typically appearing as a crystalline powder.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
486.90
Boiling point (Kelvin)
760.05
General information
Molecular weight
388.84g/mol
Molar mass
388.8370g/mol
Density
1.2900g/cm3
Appearence

It appears as a light yellow solid or powder.

Comment on solubility

Solubility of Methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate

The solubility of methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate can be intriguing due to its complex structure. Various factors influence the solubility of this compound in different solvents:

  • Polarity: The presence of polar functional groups may enhance solubility in polar solvents like water.
  • Hydrophobic Regions: The chlorobenzoyl and indole moieties can increase solubility in organic solvents such as ethyl acetate or dichloromethane.
  • Temperature: Increasing temperature often improves solubility; hence, this compound may dissolve better in hot solvents.
  • pH Levels: The solubility can vary with pH, especially if the compound can ionize in acidic or basic conditions.

As a general observation, "the solubility of organic compounds is a balance between hydrophilic and hydrophobic interactions." This means that while methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate might have limited solubility in water, it could demonstrate more favorable solubility in organic solvents, making it an important candidate for various synthetic and application processes.


Interesting facts

Interesting Facts about Methyl 2-[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-Indol-3-Yl]Acetate

Methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate is a fascinating chemical compound that plays a significant role in various fields of research. Here are some intriguing aspects of this compound:

  • Structural Complexity: This compound possesses a unique structure that includes both indole and methoxy groups, contributing to its diverse reactivity and functionality.
  • Potential Biological Activity: Compounds featuring the indole structure are often studied for their biological properties, including anti-cancer, anti-inflammatory, and antimicrobial activities.
  • Synthetic Applications: Methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate can be synthesized through various organic reactions, showcasing its utility in synthetic organic chemistry.
  • Pharmaceutical Relevance: Due to its intricate structure, there is a growing interest in exploring its efficacy in drug development and medicinal chemistry.
  • Versatility of Indole Derivatives: Indole derivatives like this one are prominently found in numerous natural products, and studying them can reveal important insights into their function in biological systems.

As a scientist or chemistry student, diving into the study of methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate opens the door to numerous research opportunities, especially when considering its potential applications in drug design and development.

In the words of renowned chemist, "The exploration of complex chemical compounds is where creativity meets scientific discipline." This quote embodies the spirit of discovery that compounds like this one inspire in the scientific community.

Synonyms
1601-18-9
Indomethacin Methyl Ester
Methyl 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetate
Methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, methyl ester
methyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate
INDOLE-3-ACETIC ACID, 1-(p-CHLOROBENZOYL)-5-METHOXY-2-METHYL-, METHYL ESTER
MFCD01719291
CHEMBL73572
1-(p-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid methyl ester
Methyl [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate (Indomethacin Methyl Ester)
EINECS 216-494-8
Indomethacin, methyl ester
BRN 0496619
C20H18ClNO4
Indometacin methylester
Indometacin methyl ester
Indomethacin derivative, 5
Indomethacine, methyl ester
Indomethacin, methyl deriv.
Methyl ester of Indomethacin
SCHEMBL14086813
BDBM22952
DTXSID30166800
V7N8G32K46
AKOS022181585
Indomethacin Impurity H [EP Impurity]
DA-33300
DS-15077
SY115795
CS-0061203
NS00025214
W17150
L-588983
Methyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
Methyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate #
Methyl 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl]acetate
Methyl [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-ylmethyl]acetate
methyl 2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetate