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Nintedanib

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Identification
Molecular formula
C31H33N5O4
CAS number
656247-17-5
IUPAC name
methyl 2-[(2-methyl-4-pyridyl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate
State
State

Nintedanib is a solid at room temperature and is typically handled in powder form.

Melting point (Celsius)
254.80
Melting point (Kelvin)
528.00
Boiling point (Celsius)
617.35
Boiling point (Kelvin)
890.50
General information
Molecular weight
539.57g/mol
Molar mass
539.5650g/mol
Density
1.3643g/cm3
Appearence

Nintedanib is typically found as a yellowish powder.

Comment on solubility

Solubility of Methyl 2-[(2-methyl-4-pyridyl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate

The solubility of the compound methyl 2-[(2-methyl-4-pyridyl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate (C31H33N5O4) can be quite complex due to its intricate structure. Here are some key points about its solubility:

  • Polar and Non-Polar Character: The presence of multiple functional groups, including carboxylate and methoxy moieties, suggests that this compound may exhibit varying degrees of solubility in both polar and non-polar solvents.
  • Solvent Interaction: The solubility can be influenced by the choice of solvent. For instance, it may dissolve well in dimethyl sulfoxide (DMSO) or dimethylformamide (DMF), but poorly in non-polar solvents like hexane.
  • pH Dependence: The solubility may also change with pH, especially due to the weakly acidic nature of the carboxylate group, leading to increased solubility at higher pH levels.
  • Temperature Effects: Like many organic compounds, solubility typically increases with temperature, which can be critical for practical applications.

This compound's solubility characteristics highlight the importance of considering the molecular structure when predicting how it may behave in different environments, making it a fascinating subject for further study.

Interesting facts

Interesting Facts about Methyl 2-[(2-methyl-4-pyridyl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate

Methyl 2-[(2-methyl-4-pyridyl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate, a compound boasting a complex structure, is renowned in scientific research for several compelling reasons:

  • Diverse Applications: This compound is particularly noteworthy for its potential applications in medicinal chemistry, where it has been studied for its role as a potent antimicrobial and anti-inflammatory agent.
  • Structural Complexity: The molecule possesses a rich array of functional groups, enhancing its reactivity and interaction with biological systems. Specifically, the presence of naphthyridine and pyridine rings contributes to its pharmacological activities.
  • Research Impact: Studies have shown that compounds like this one can modulate various biological pathways, making them valuable in drug design targeting diseases such as cancer and neurodegenerative disorders.
  • Synthesis Challenges: The synthesis of such compounds often involves multiple steps, raising challenges in terms of yield and purity. This complex synthesis allows chemists to explore novel methodologies in organic reactions.

As chemistry students delve into the fascinating world of organic compounds, the study of this compound emphasizes the importance of chemical diversity and its implications in advancements within medicinal chemistry. The exploration of compounds such as this one not only enriches the scientific community's understanding but also paves the way for the development of potential therapeutic agents.

In summary, methyl 2-[(2-methyl-4-pyridyl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate stands as a prime example of the intersection of chemistry and medicine, showcasing the incredible possibilities held within intricate molecular structures.

Synonyms
t-0156
324572-92-1
T0156
methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-2,7-naphthyridine-3-carboxylate
Methyl 2-((2-methylpyridin-4-yl)methyl)-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-2,7-naphthyridine-3-carboxylate
methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate
CHEMBL540294
NCGC00016057-01
Tocris-1676
Lopac-T-8067
Lopac0_001212
SCHEMBL687326
GTPL5275
CHEMBL1190161
CHEBI:93111
JEMJAABFSYOLAP-UHFFFAOYSA-N
DTXSID401045746
BDBM50130017
HSCI1_000141
CCG-205286
NCGC00016057-02
NCGC00016057-03
NCGC00025257-01
NCGC00025257-02
BRD-K63516691-001-01-6
BRD-K63516691-003-01-2
BRD-K63516691-003-02-0
Q27088906
(2-methylpyridin-4-yl)methyl-4-(3,4,5-trimethoxyphenyl)-8-(pyrimidin-2-yl)methoxy-1,2-dihydro-1-oxo-2,7-naphthyridine-3-carboxylic acid methyl ester hydrochloride
2-(2-Methyl-pyridin-4-ylmethyl)-1-oxo-8-(pyrimidin-2-ylmethoxy)-4-(3,4,5-trimethoxy-phenyl)-1,2-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester; hydrochloride