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Vincamine

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Identification
Molecular formula
C21H26N2O3
CAS number
1617-90-9
IUPAC name
methyl 2-[(2S,3S)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxy-prop-2-enoate
State
State

At room temperature, Vincamine is generally found as a solid.

Melting point (Celsius)
149.00
Melting point (Kelvin)
422.15
Boiling point (Celsius)
260.00
Boiling point (Kelvin)
533.15
General information
Molecular weight
383.47g/mol
Molar mass
383.4680g/mol
Density
1.3000g/cm3
Appearence

Vincamine appears as a white to off-white crystalline powder. It is typically odorless and is noted for its glossy, fibrous crystalline structure.

Comment on solubility

Solubility of Methyl 2-[(2S,3S)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxy-prop-2-enoate

The solubility of methyl 2-[(2S,3S)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxy-prop-2-enoate is influenced by several factors due to its complex chemical structure.

Here are some key points regarding its solubility:

  • Polar vs. Non-Polar: The presence of multiple methoxy (–OCH3) groups suggests that the compound may possess moderate polarity, which can enhance solubility in polar solvents such as water and alcohols.
  • Hydrophobic Regions: The indoloquinolizin structure, with its extensive cyclic and aromatic systems, can impart significant hydrophobic properties, making the compound less soluble in aqueous environments.
  • Solvent Compatibility: For effective dissolution, a compatible solvent, such as DMSO or ethanol, might be required to overcome the hydrophobic interactions.
  • Temperature Influence: Increasing temperature often enhances solubility for many organic compounds. Thus, heating a solution may facilitate a greater dissolution rate for this compound.

In summary, while methyl 2-[(2S,3S)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxy-prop-2-enoate may show some solubility in polar solvents, its hydrophobic characteristics could limit its overall solubility profile. Understanding these aspects is crucial for practical applications in pharmaceuticals and other fields.

Interesting facts

Interesting Facts about Methyl 2-[(2S,3S)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxy-prop-2-enoate

This compound presents a fascinating intersection of chemistry and potential pharmacological applications. Here are some noteworthy aspects:

  • Structural Complexity: The intricate structure of this compound features an octahydroindolo framework, which is notable for its multifaceted carbon skeleton. This complexity often correlates with unique biological properties.
  • Natural Products: Many compounds related to this structure are found in nature, particularly in plants. They often have diverse biological activities, making them of interest in the field of natural product chemistry.
  • Stereochemistry: The presence of stereocenters signifies that this compound can exhibit chirality, which is crucial in understanding how it interacts with biological systems. Chirality can affect the compound's behavior in enzymatic reactions and its overall efficacy in pharmaceutical applications.
  • Potential Therapeutic Effects: Compounds with similar structural motifs have been studied for their potential effects against various diseases, including cancer and neurological disorders. Research continues to explore such compounds as lead candidates in drug discovery.
  • Functional Groups: The presence of methoxy groups enhances the compound's ability to engage in hydrogen bonding and affects its reactivity, potentially influencing its solubility and interactions with biological molecules.

As a result, methyl 2-[(2S,3S)-3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl]-3-methoxy-prop-2-enoate serves as an intriguing subject for further study in organic synthesis and medicinal chemistry. Its structural attributes not only invite investigations into its properties but also spark interest in its possible applications in improving human health.

Synonyms
NS00096385