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Methyl 2-fluoroacetate

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Identification
Molecular formula
C3H5FO2
CAS number
453-18-9
IUPAC name
methyl 2-fluoroacetate
State
State
Methyl 2-fluoroacetate is in liquid state at room temperature.
Melting point (Celsius)
-82.00
Melting point (Kelvin)
191.15
Boiling point (Celsius)
104.00
Boiling point (Kelvin)
377.15
General information
Molecular weight
106.07g/mol
Molar mass
106.0820g/mol
Density
1.1872g/cm3
Appearence

Methyl 2-fluoroacetate is a clear, colorless liquid.

Comment on solubility

Solubility of Methyl 2-Fluoroacetate

Methyl 2-fluoroacetate, with the chemical formula C3H5F1O2, showcases intriguing solubility characteristics that make it an interesting compound to study. Many factors influence its solubility in different solvents:

  • Polar Nature: Due to the presence of both a polar carbonyl group (C=O) and a fluorine atom, methyl 2-fluoroacetate tends to be more soluble in polar solvents.
  • Solvent Compatibility: It is generally soluble in water, as well as in organic solvents such as ethanol and acetone.
  • Hydrogen Bonding: The molecule can engage in hydrogen bonding, which further enhances its solubility in polar solvents.

As a general rule, one can remember that “like dissolves like.” Thus:

  • If you're considering using this compound in an aqueous environment, it's favorable due to its solubility.
  • However, in non-polar solvents, the solubility may significantly decrease.

In practical applications, the solubility of methyl 2-fluoroacetate plays a crucial role in its utilization in organic synthesis, where it can effectively participate in nucleophilic reactions in solvents that favor its dissolution.

Interesting facts

Interesting Facts About Methyl 2-Fluoroacetate

Methyl 2-fluoroacetate is a fascinating organic compound known for its diverse applications and significance in various fields. Here are some key points that make this compound particularly interesting:

  • Fluorine's Role: The presence of the fluorine atom in methyl 2-fluoroacetate dramatically influences its chemical properties, making it a valuable reagent in organic synthesis. Fluorinated compounds often exhibit enhanced biological activity compared to their non-fluorinated counterparts.
  • Synthetic Building Block: This compound serves as a crucial building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the introduction of fluorine into larger molecules, which can enhance their effectiveness.
  • Applications in Medicine: The fluoroacetate moiety is often involved in the design of drugs, especially for treating diseases like cancer and bacterial infections. The increased stability and bioavailability due to fluorination can lead to improved therapeutic outcomes.
  • Environmental Impact: While methyl 2-fluoroacetate has many uses, like any chemical, its environmental impact should be assessed. Scientists are continuously studying the degradation pathways of fluorinated compounds to understand their ecological effects.

In conclusion, methyl 2-fluoroacetate stands as a testament to the importance of fluoro compounds in modern chemistry. Its applications span from synthetic chemistry to medicinal research, underscoring its value in developing innovative solutions for health and industry.

Synonyms
Methyl fluoroacetate
453-18-9
methyl 2-fluoroacetate
Fluoroacetic Acid Methyl Ester
Fluoroacetic acid, methyl ester
ACETIC ACID, FLUORO-, METHYL ESTER
METHYLFLUOROACETATE
TL 551
Methylester kyseliny fluoroctove
MO8U9H1FAS
EINECS 207-218-7
BRN 1740631
Methylester kyseliny fluoroctove [Czech]
Fluoracetic acid methyl ester
DTXSID3073185
HSDB 8462
FLUOROACETIC ACID METHYL ESTER [MI]
ACETIC ACID, 2-FLUORO-, METHYL ESTER
UNII-MO8U9H1FAS
MFCD00040096
2-Fluoro-1-methoxyethan-1-one
DTXCID4040399
AC-590
BBL100478
STL554272
AKOS005254621
FM104357
F0183
NS00031519
F11448
InChI=1/C3H5FO2/c1-6-3(5)2-4/h2H2,1H
Q15633283
207-218-7