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Methylphenidate hydrochloride

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Identification
Molecular formula
C14H19NO2·HCl
CAS number
298-59-9
IUPAC name
methyl 2-phenyl-2-(2-piperidyl)acetate;hydrochloride
State
State

Methylphenidate hydrochloride is typically found as a solid at room temperature. It is stable under standard conditions of temperature and pressure.

Melting point (Celsius)
225.00
Melting point (Kelvin)
498.00
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.00
General information
Molecular weight
269.77g/mol
Molar mass
269.7700g/mol
Density
1.3000g/cm3
Appearence

The compound typically appears as a fine, white, crystalline powder. It is often odorless and has a slightly bitter taste.

Comment on solubility

Solubility of Methyl 2-phenyl-2-(2-piperidyl)acetate; Hydrochloride

The solubility of methyl 2-phenyl-2-(2-piperidyl)acetate; hydrochloride can be quite characteristic and is affected by several factors. Understanding its solubility is essential for various applications, particularly in pharmaceutical formulations. Here are some points to consider:

  • Water Solubility: Generally, salts such as the hydrochloride form of a compound tend to have higher solubility in water compared to their neutral counterparts. Thus, methyl 2-phenyl-2-(2-piperidyl)acetate; hydrochloride may display moderate to high solubility in aqueous solutions.
  • Influence of pH: The solubility of this compound can significantly vary with pH levels. It is likely to be more soluble in acidic conditions due to the protonation of the amine group, enhancing aqueous solubility.
  • Solvent Compatibility: This compound may also be soluble in organic solvents such as ethanol and methanol to a certain extent, which can aid in its application in laboratory settings.
  • Cationic Properties: Being a hydrochloride, the presence of the chloride ion can also influence solubility patterns, providing beneficial interactions with water molecules.

In summary, the solubility characteristics of methyl 2-phenyl-2-(2-piperidyl)acetate; hydrochloride suggest versatility in different solvent systems. This enhances its utility in various chemical processes and applications. A thorough understanding of its solubility is crucial for effective utilization in scientific studies.

Interesting facts

Interesting Facts about Methyl 2-phenyl-2-(2-piperidyl)acetate; Hydrochloride

Methyl 2-phenyl-2-(2-piperidyl)acetate; hydrochloride is a unique compound that has garnered the attention of chemists due to its structural complexity and potential applications. Below are some intriguing highlights:

  • Structural Versatility: The compound features a piperidine ring, which contributes to its chemical reactivity and facilitates various substitution reactions. This structural element makes it an essential building block in synthetic organic chemistry.
  • Pharmacological Potential: Compounds that contain piperidine are often explored for their pharmacological properties. Studies indicate that derivatives like this one may exhibit interesting biological activities, making them candidates for drug development.
  • Synthesis Insights: The synthesis of methyl 2-phenyl-2-(2-piperidyl)acetate; hydrochloride involves several key reactions, including esterification and amine alkylation, showcasing the intricacies of organic synthesis.
  • Research Applications: This compound may play a role in understanding neurochemical pathways, as piperidine derivatives are known to interact with neurotransmitter systems, adding a layer of complexity to pharmacological assessments.

In the words of renowned chemist "Organic chemistry is the chemistry of life, and every compound tells its own story." Methyl 2-phenyl-2-(2-piperidyl)acetate; hydrochloride certainly has a narrative worthy of exploration and investigation in both academic and industrial contexts.

As ongoing research continues to unveil new applications and properties, this compound represents a fascinating intersection of synthetic chemistry and pharmacology. Its study not only broadens our understanding of chemical space but also exemplifies the continuous quest for innovative solutions in medicine.

Synonyms
METHYLPHENIDATE HYDROCHLORIDE
298-59-9
Centedrin
Ritalin
Methylphenidate HCl
Centedrine
Ritalin hydrochloride
Concerta
Methylin ER
Ritalin LA
Methylphenidate.HCl
Metadate
Methylin
Quillivant XR
QuilliChew ER
Metilfenidat hydrochloride
Metadate CD
Ritalin SR
H-Tic-OtBu.HCl
Quillichew
Quillivant
Aptensio
Foquest
Metadate ER
Methylphenidylacetate hydrochloride
Oros mph
Threo-methylphenidate hydrochloride
Aptensio XR
Daytrana
DTXSID8020886
Methylphenidate(Ritalin)
NSC-169868
Methyl alpha-phenyl-2-piperidineacetate hydrochloride
Equasym
DTXCID20886
Methylphenidate (hydrochloride)
SPD544
CHEBI:31836
SPD-544
Ritalin-SR
NSC169868
methyl 2-phenyl-2-piperidin-2-ylacetate;hydrochloride
NCGC00091942-01
Rilaline
d,l-Methylphenidate.HCl
methyl phenyl(piperidin-2-yl)acetate hydrochloride
Meridil hydrochloride
Rilatine
ADHANSIA XR
JORNAY PM
CAS-298-59-9
NSC 169868
CCRIS 6258
Methyl 2-phenyl-2-(piperidin-2-yl)acetate hydrochloride
EINECS 206-065-3
Methylphenidate Hydrochloride (1.0 mg/mL in Methanol)
Hydrochloride, Methylphenidate
QuillivantXR
RitalinLA
Methylphenidate Hydrochloride ER
Concerta (TN)
Metadate (TN)
Ritalin (TN)
RELEXXII
METHYLPHENIDATE HYDROCHLORIDE (MART.)
Quillivant xr (TN)
Methylphenidate hydrochloride [USP:JAN]
METHYLPHENIDATE HYDROCHLORIDE CII (USP-RS)
METHYLPHENIDATE HYDROCHLORIDE (EP MONOGRAPH)
METHYLPHENIDATE HYDROCHLORIDE (USP MONOGRAPH)
JORNAY PMExtended-Release
CHEMBL1722
SCHEMBL41067
MLS003922100
(methylphenidate hydrochloride)
DL-Methylphenidate hydrochloride
Methylphenidate Hydrochloride CD
Methylphenidate hydrochloride cii
HY-B1091A
Methylphenidate Hydrochloride(CD)
Methylphenidate Hydrochloride(LA)
Methylphenidate-d10 hydrochloride
Methylphenidate Hydrochloride (la)
Pharmakon1600-01505907
alpha-phenyl-2-piperidineacetic acid methyl ester hydrochloride
BCP34044
EBA41996
WZB81919
Tox21_111186
Tox21_200309
2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride
METHYL PHENIDATE HYDROCHLORIDE
MFCD00058191
NSC759278
AKOS016010356
CCG-213572
CS-4658
FM35271
NSC-759278
SB13180
WLN: T6MTJ BYR & VO1 & GH
2-Piperidineacetic acid, alpha-phenyl-, methyl ester, hydrochloride, (R*,R*)-(+-)-
Methylphenidate hydrochloride (JAN/USP)
NCGC00257863-01
SMR000058998
Methylphenidate HydrochlorideExtended-Release
NS00079660
Methylphenidate Hydrochloride Extended Release
methylphyenidate hydrochloride extended-release
D01296
2-Piperidineacetic acid, methyl ester, hydrochloride
Methylphenidate HCl;Threo-methylphenidate hydrochloride
Q26840773
Methyl .alpha.-phenyl-2-piperidineacetate hydrochloride
METHYL 2-PHENYL-2-(PIPERIDIN-2-YL)ACETATE HCL
d,l-Methylphenidate.HCl, 1mg/ml in Methanol (as free base)
Methylphenidate hydrochloride, European Pharmacopoeia (EP) Reference Standard
206-065-3