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Methyl 2,2-difluoro-2-nitroacetate

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Identification
Molecular formula
C4H5F2NO4
CAS number
145598-23-8
IUPAC name
methyl 2,2-difluoro-2-nitro-acetate
State
State

At room temperature, methyl 2,2-difluoro-2-nitroacetate is typically in a liquid state.

Melting point (Celsius)
-78.00
Melting point (Kelvin)
195.15
Boiling point (Celsius)
144.00
Boiling point (Kelvin)
417.15
General information
Molecular weight
167.08g/mol
Molar mass
167.0660g/mol
Density
1.4220g/cm3
Appearence

Methyl 2,2-difluoro-2-nitroacetate is a colorless to pale yellow liquid. It is typically clear and can have a slight pungent odor due to the nitro group present in its structure.

Comment on solubility

Solubility of Methyl 2,2-Difluoro-2-Nitro-Acetate

Methyl 2,2-difluoro-2-nitro-acetate, with its unique molecular structure, exhibits interesting solubility characteristics that are crucial for its applications in various chemical processes. Understanding its solubility can help in predicting its behavior in different solvents and environments.

Key Solubility Points:

  • Polar Solvents: Methyl 2,2-difluoro-2-nitro-acetate is expected to be soluble in polar solvents due to its nitro and fluorine groups, which can engage in dipole-dipole interactions.
  • Non-Polar Solvents: In contrast, its solubility in non-polar solvents is likely to be limited, as the presence of electronegative fluorine atoms creates regions of dipole character that do not favor solvation by non-polar species.
  • Temperature Dependence: The solubility can also vary significantly with temperature; increasing the temperature may enhance solubility, allowing for a broader range of applications in synthesis and extraction processes.

As with many organic compounds, the solubility of methyl 2,2-difluoro-2-nitro-acetate is a function of its molecular interactions. The ability to dissolve in various solvents can impact its reactivity and overall utility in chemical formulations. It is essential to conduct further studies to determine precise solubility limits and behavior under varying conditions. Always remember, effective solubility assessments play a pivotal role in the development and application of chemical compounds.

Interesting facts

Interesting Facts About Methyl 2,2-Difluoro-2-Nitro-Acetate

Methyl 2,2-difluoro-2-nitro-acetate is a fascinating chemical compound that finds utility in various fields such as pharmaceuticals, agrochemicals, and material science. Here are some interesting aspects of this compound:

  • Fluorinated Derivative: The presence of fluorine atoms in its structure sets this compound apart. Fluorination can enhance the compound's biological activity, reflective of the *"fluorine effect,"* which makes pharmaceuticals more potent or selective.
  • Role in Synthesis: Methyl 2,2-difluoro-2-nitro-acetate can serve as an important intermediate in organic synthesis, allowing chemists to create complex molecules through various reactions, such as nucleophilic substitution.
  • Applications in Drug Development: Due to its unique chemical properties, it can also be explored in the development of new drugs, especially those targeting specific biological pathways, owing to the modifications that the nitrogen and fluorine atoms bring to the molecular framework.
  • Environmental Impact: Understanding the environmental behavior of compounds like methyl 2,2-difluoro-2-nitro-acetate is crucial. Researchers study its degradation pathways to assess its fate in ecosystems, given the increasing scrutiny on fluorinated compounds due to their potential persistence in the environment.
  • Analytical Techniques: This compound is often analyzed using techniques such as NMR (Nuclear Magnetic Resonance) and mass spectrometry, allowing scientists to elucidate its structure and confirm its purity during synthesis.

In summary, methyl 2,2-difluoro-2-nitro-acetate stands out due to its unique functional group arrangement, making it a subject of interest for synthetic chemists and researchers alike. Its intriguing blend of properties results in a compound that not only contributes to the advancement of chemical sciences but also opens new avenues in developing innovative solutions across various industries.

Synonyms
Methyl difluoronitroacetate
428-13-7
ACETIC ACID, DIFLUORONITRO-, METHYL ESTER
BRN 1775232
4-02-00-00540 (Beilstein Handbook Reference)
DTXSID60195486
Difluoronitroacetic acid methyl ester
SCHEMBL23829928
DTXCID70117977
WTHNVDSODCAINI-UHFFFAOYSA-N