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Methyl 2,2,2-trifluoroacetate

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Identification
Molecular formula
C3H3F3O2
CAS number
431-47-0
IUPAC name
methyl 2,2,2-trifluoroacetate
State
State

At room temperature, methyl 2,2,2-trifluoroacetate remains in a liquid state. It is often used in organic synthesis and due to its volatile nature, care should be taken to store it appropriately to avoid rapid evaporation and loss.

Melting point (Celsius)
-90.00
Melting point (Kelvin)
183.15
Boiling point (Celsius)
47.00
Boiling point (Kelvin)
320.15
General information
Molecular weight
142.07g/mol
Molar mass
142.0710g/mol
Density
1.2557g/cm3
Appearence

Methyl 2,2,2-trifluoroacetate is a colorless liquid that may appear slightly hazy due to its volatility and sensitivity to moisture. It usually has a pungent, sweet odor which is typical of esters that contain fluoroalkyl groups.

Comment on solubility

Solubility of Methyl 2,2,2-trifluoroacetate

Methyl 2,2,2-trifluoroacetate, with the chemical formula C3H3F3O2, exhibits notable solubility properties, which can be described as follows:

General Solubility Characteristics

This compound is known for its moderate solubility in water, primarily due to the presence of the electronegative fluorine atoms which create a polar environment. The trifluoroacetate group significantly influences its solubility:

  • In Polar Solvents: Methyl 2,2,2-trifluoroacetate is highly soluble in polar solvents such as ethanol and methanol.
  • In Non-Polar Solvents: Its solubility in non-polar solvents tends to be lower as the polar character does not interact favorably.

Factors Influencing Solubility

Several factors affect the solubility of this compound:

  • Temperature: As with many compounds, increased temperature generally enhances solubility.
  • pH Level: The solubility may vary in different pH levels, potentially affecting the ionization state of the compound.

In conclusion, while methyl 2,2,2-trifluoroacetate shows a degree of water solubility, its behavior in various solvents underscores the intricacies of molecular interactions. As the saying goes, "Like dissolves like," which aptly describes the relationship between this compound and its solvents.

Interesting facts

Exploring Methyl 2,2,2-Trifluoroacetate

Methyl 2,2,2-trifluoroacetate (commonly known as trifluoroacetic acid methyl ester) is a fascinating compound that belongs to the family of trifluoroacetic acid derivatives. This compound has garnered attention in both academic and industrial fields for several compelling reasons:

  • Versatile Reactivity: Methyl 2,2,2-trifluoroacetate is renowned for its reactivity as an acylating agent and can serve as a valuable building block in the synthesis of various organic compounds, particularly in pharmaceuticals and agrochemicals.
  • Fluorinated Compound: The incorporation of fluorine atoms into its structure significantly enhances the compound's lipophilicity and stability. This makes it a powerful tool in drug design, enabling scientists to engineer molecules with specific biological properties.
  • Biological Applications: Research indicates potential applications of methyl 2,2,2-trifluoroacetate in the development of antiviral and antitumor agents. Its efficacy stems from the unique electronic and steric properties that the fluorine atoms bestow upon the molecule, which can influence how it interacts with biological targets.
  • Environmental Considerations: Understanding the environmental impact of trifluoroacetate derivatives is crucial, as compounds with fluorine can contribute to greenhouse gas emissions. Thus, ongoing research focuses on minimizing potential ecological harm while maximizing their benefits in synthetic applications.
  • Innovation in Synthesis: The compound acts as a crucial intermediate in various multistep organic syntheses. Its unique reactivity can streamline multiple synthetic pathways, making it a favorite among synthetic chemists seeking efficiency in complex compound creation.

With its intriguing properties and applications, methyl 2,2,2-trifluoroacetate stands out as a key compound in modern chemistry. As research continues to evolve, the potential uses and implications of this compound are sure to expand, revealing even more about its significance in both industrial and scientific endeavors.

Synonyms
METHYL TRIFLUOROACETATE
431-47-0
methyl 2,2,2-trifluoroacetate
Acetic acid, trifluoro-, methyl ester
Trifluoroacetic acid methyl ester
methyltrifluoroacetate
EINECS 207-074-5
CF3C(O)OCH3
DTXSID2059988
Acetic acid, 2,2,2-trifluoro-, methyl ester
Methyl 2,2,2-trifluoroacetate; Methyl Perfluoroacetate
MFCD00000417
methyl trifluoracetate
Methyl triflouroacetate
methyl2,2,2-trifluoroacetate
Methyl trifluoroacetate, 99%
SCHEMBL111507
DTXCID3040225
IIRVPHDDBOAHCJ-UHFFFAOYSA-N
VLUMWUXJMUMKDM-UHFFFAOYSA-N
WEADNOMQQFORBX-UHFFFAOYSA-N
Acetic acid, trifluoro, methyl ester
AKOS005063972
CS-W013477
FM104406
LS-12950
Acetic acid, 2,2,2trifluoro, methyl ester
DB-051040
NS00022187
T0680
EN300-20643
D78309
F0001-1190
207-074-5