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Methyl 2,4-dihydroxybenzoate

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Identification
Molecular formula
C8H8O4
CAS number
2150-44-5
IUPAC name
methyl 2,4-dihydroxybenzoate
State
State

At room temperature, methyl 2,4-dihydroxybenzoate is typically found in a solid state.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.15
Boiling point (Celsius)
326.90
Boiling point (Kelvin)
600.05
General information
Molecular weight
168.15g/mol
Molar mass
168.1500g/mol
Density
1.3000g/cm3
Appearence

Methyl 2,4-dihydroxybenzoate typically presents as a crystalline solid. Its color ranges from white to off-white, and it may form fine grains or powder.

Comment on solubility

Solubility of Methyl 2,4-Dihydroxybenzoate

Methyl 2,4-dihydroxybenzoate, also known as methyl salicylate, exhibits notable solubility characteristics that are of interest in various applications. Its solubility can be summarized as follows:

  • Water Solubility: This compound is generally poorly soluble in water. However, it exhibits some degree of solubility due to its ability to form hydrogen bonds.
  • Solubility in Organic Solvents:
    • Readily soluble in ethanol
    • Soluble in chloroform
    • Readily dissolves in other non-polar solvents
  • Temperature Effect: The solubility of methyl 2,4-dihydroxybenzoate tends to increase with temperature in organic solvents, allowing for improved interactions.

This variability in solubility is essential for its application in formulations like lotions, ointments, and other pharmaceutical products. The interactions with solvents underline its importance in the field of drug delivery and formulation chemistry.

In summary, understanding the solubility of methyl 2,4-dihydroxybenzoate helps researchers and formulators determine the best conditions for its use:

  • Influences bioavailability in medicinal applications
  • Guides the choice of solvents in various formulations
  • Significant in determining stability and efficacy

Ultimately, the solubility profile of methyl 2,4-dihydroxybenzoate highlights its versatility and relevance in chemical and pharmaceutical sciences.

Interesting facts

Interesting Facts about Methyl 2,4-Dihydroxybenzoate

Methyl 2,4-dihydroxybenzoate, commonly known as methyl paraben, is a fascinating compound that plays a significant role in both the chemical and cosmetic industries. It is widely recognized for its effectiveness as a preservative, primarily in personal care products, pharmaceuticals, and food items. Here are some key points that highlight its importance:

  • Preservative Properties: Methyl paraben is effective against a broad range of bacteria and fungi, helping to extend the shelf life of various products.
  • Safety and Efficacy: It is considered safe for use in low concentrations, which has led to its widespread incorporation into cosmetics like lotions and shampoos.
  • Esters and Acidity: As an ester of p-hydroxybenzoic acid, methyl 2,4-dihydroxybenzoate exhibits distinctive properties that make it both stable and effective.
  • Regulatory Approval: Major health organizations, including the FDA and the European Commission, have recognized its safety, leading to its approval in various consumer goods.
  • Natural Sources: Interestingly, methyl paraben can also be found naturally in certain fruits, which adds an intriguing aspect to its presence in synthetic products.

Despite the controversies surrounding parabens and their potential links to hormonal disruption, research continues to support their use in moderation. As a keen observer of chemical interactions, one might ponder:

"In the balance of efficacy and safety, how do we navigate the complex landscape of preservative use?"

Methyl 2,4-dihydroxybenzoate remains at the forefront of ongoing discussions about preservatives in our daily lives, making it a notable compound worth studying.

Synonyms
METHYL 2,4-DIHYDROXYBENZOATE
2150-47-2
2,4-Dihydroxybenzoic acid methyl ester
Benzoic acid, 2,4-dihydroxy-, methyl ester
Methyl beta-resorcylate
Methyl-2,4-dihydroxybenzoate
.beta.-Resorcylic acid, methyl ester
Methyl .beta.-resorcylate
XE68BU3OYJ
ORISTAR MDHB24
EINECS 218-428-3
AI3-31503
DTXSID2022177
DTXCID302177
beta-Resorcylic acid, methyl ester
METHYL 2,4-DIHYDROXYBENZOATE [INCI]
218-428-3
MFCD00002276
methyl b-resorcylate
CHEMBL486026
methyl 2,4-bis(oxidanyl)benzoate
2,4-Dihydroxy-benzoic acid methyl ester
beta-Resorcylic Acid Methyl Ester
Methyl benzoate, 2,4-dihydroxy-
2,4-Dihydroxybenzoic Acid Methyl Ester; Methyl 2,4-Dihydroxybenzoate; beta-Resorcylic Acid Methyl Ester;
UNII-XE68BU3OYJ
Methyl 4-hydroxysalicylate
methyl 2,4 dihydroxybenzoate
SCHEMBL382883
methyl 2,4-dihydroxy-benzoate
BBL036382
BDBM50428378
CK2219
Methyl 2,4-dihydroxybenzoate, 97%
STL194098
AKOS000271195
AC-8707
CS-W010792
FM70757
HY-W010076
AC-11617
DS-15488
SY015923
DB-045603
M1796
NS00026885
EN300-109864
AH-034/32464017
Q27293803
Z25218921
F1982-0001
InChI=1/C8H8O4/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4,9-10H,1H
HF9