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Methyl 3-(1H-indol-3-yl)propanoate

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Identification
Molecular formula
C12H13NO2
CAS number
32595-35-2
IUPAC name
methyl 3-(1H-indol-3-yl)propanoate
State
State
At room temperature, methyl 3-(1H-indol-3-yl)propanoate is typically found as a liquid. It can also appear crystalline when subjected to lower temperatures or specific atmospheric conditions.
Melting point (Celsius)
21.00
Melting point (Kelvin)
294.15
Boiling point (Celsius)
364.20
Boiling point (Kelvin)
637.35
General information
Molecular weight
217.24g/mol
Molar mass
217.2700g/mol
Density
1.1510g/cm3
Appearence

Methyl 3-(1H-indol-3-yl)propanoate appears as a colorless to slightly yellow liquid. It may also be found in crystalline form, depending on the conditions of the surrounding environment. The compound is typically clear when pure and can have a faint aromatic odor owing to the indole group present in its structure.

Comment on solubility

Solubility of Methyl 3-(1H-indol-3-yl)propanoate

Methyl 3-(1H-indol-3-yl)propanoate, with its complex structure, exhibits a noteworthy solubility profile in various solvents, primarily influenced by its functional groups and molecular interactions. Here are some key points to consider:

  • Polar Solvents: This compound tends to be soluble in polar solvents such as water and methanol due to its ability to engage in hydrogen bonding.
  • Apolar Solvents: It shows limited solubility in non-polar solvents like hexane, as the hydrophobic nature of the indole ring inhibits effective dissolution.
  • Concentration Dependence: The solubility can vary significantly with temperature and concentration; higher temperatures generally enhance solubility.
  • pH Influence: The solubility may also be affected by the pH of the solution, as ionization of specific functional groups can alter its solubility characteristics.

In summary, the solubility of methyl 3-(1H-indol-3-yl)propanoate is predominantly influenced by its polar nature, allowing it to dissolve readily in suitable solvents while facing challenges in non-polar environments. Understanding these solubility traits is essential for applications in both laboratory and industrial settings.

Interesting facts

Interesting Facts about Methyl 3-(1H-indol-3-yl)propanoate

Methyl 3-(1H-indol-3-yl)propanoate is a fascinating compound that showcases the interplay of chemistry and biological activity. Here are some thought-provoking facts:

  • Natural Origins: This compound can be found in nature, as it is derived from indole, a structure common in many natural products. Indole and its derivatives are significant in the field of pharmacology due to their diverse biological activities.
  • Pharmacological Relevance: Methyl 3-(1H-indol-3-yl)propanoate is of interest due to its potential medicinal properties. Compounds with an indole backbone have been studied for their roles in treating various diseases, showing promise in antitumor and anti-inflammatory applications.
  • Versatile Synthetic Routes: The synthesis of this compound is quite versatile. Chemists can employ a variety of methods to create methyl 3-(1H-indol-3-yl)propanoate, allowing for the exploration of its derivatives and analogs. This flexibility in synthesis encourages experimentation in discovering new functional properties.
  • Research Opportunities: As researchers continue to uncover the complexities of chemical compounds, methyl 3-(1H-indol-3-yl)propanoate serves as an exciting template for the creation of novel materials and pharmaceuticals. Its structural features make it an attractive target for structure-activity relationship (SAR) studies.
  • Interdisciplinary Connections: This compound bridges several scientific fields, including organic chemistry, medicinal chemistry, and pharmacognosy, elucidating the importance of interdisciplinary research in advancing our understanding of chemical properties and biological functions.

As scientists and students unravel the potential of methyl 3-(1H-indol-3-yl)propanoate, the ongoing research around this compound highlights the richness of chemical diversity and its implications in the scientific community.

Synonyms
Methyl 3-(1H-indol-3-yl)propanoate
5548-09-4
Methyl indole-3-propanoate
1H-Indole-3-propanoic acid, methyl ester
Methyl 3-(indol-3-yl)propionate
Methyl indole-3-propionate
1H-Indole-3-propionic acid methyl ester
3-(1H-Indol-3-yl)-propionic acid methyl ester
Methyl 3-indolepropionate
INDOLE-3-PROPIONIC ACID, METHYL ESTER
C12H13NO2
MFCD00022778
PR3BRO222F
Methyl 1H-Indole-3-propanoate
Propionic acid, 3-(3-indolyl)-, methyl ester
NSC-56004
Methyl .beta.-(3-indolyl)-propionate
Methyl 3-(3-indolyl)propanoate
Methyl beta-(3-indolyl)-propionate
NSC 56004
BRN 0171479
UNII-PR3BRO222F
SCHEMBL290808
CHEMBL388749
DTXSID50204056
methyl 3-(3-indolyl)-propanoate
indole-3-propionic acidmethyl ester
NSC56004
Methyl3-(1H-indol-3-yl)propanoate
methyl 3-(1H-indol-3-yl)propionate
methyl 3-(3-indolylmethyl)propanoate
AKOS000588653
CCG-105130
DS-5840
Methyl 3-(1H-indol-3-yl)propanoate #
SY139430
3-INDOLEPROPIONIC ACID METHYL ESTER
DB-142919
DB-351907
CS-0139207
C75599
EN300-110930
5-22-03-00115 (Beilstein Handbook Reference)
AG-690/12868747
Q27286720
Z13758675