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Amitriptyline hydrochloride

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Identification
Molecular formula
C20H24ClN
CAS number
549-18-8
IUPAC name
methyl-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propyl]ammonium;chloride
State
State

This compound is typically in a solid state at room temperature.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
221.00
Boiling point (Kelvin)
494.15
General information
Molecular weight
313.87g/mol
Molar mass
313.8700g/mol
Density
1.0067g/cm3
Appearence

Amitriptyline hydrochloride typically appears as a white or off-white crystalline powder. It is odorless or may have a faint odor.

Comment on solubility

Solubility of Methyl-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propyl]ammonium Chloride

The solubility of methyl-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propyl]ammonium chloride can be intriguing due to its complex structure and the presence of both hydrophobic and hydrophilic characteristics. Here are several key points regarding its solubility:

  • Influence of Alkyl Chain: The lengthy alkyl chain in its structure may promote hydrophobic interactions, potentially resulting in lower solubility in polar solvents such as water.
  • Ammonium Ion: The presence of the ammonium ion increases the compound's affinity for water, which could enhance its solubility compared to wholly hydrophobic compounds.
  • Chloride Ion: As a chloride salt, it is likely soluble in many organic solvent systems, particularly those that can solvate chlorides.
  • Complexity of Structure: The intricate arrangement of cycloalkane structures may hinder effective solvation, suggesting variable solubility depending on the solvent environment.

In summary, while the compound may exhibit some degree of solubility in polar solvents due to its ionic nature, the bulky hydrophobic portions can lead to limited solubility overall. The interplay of these various factors makes it a compound of interest for further solubility exploration.

Interesting facts

Methyl-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propyl]ammonium; chloride

This intriguing compound features a complex structure, showcasing the fascinating interplay between organic chemistry and molecular design. It belongs to the category of quaternary ammonium salts, which are known for their diverse applications, particularly in the field of biochemistry and material science.

Structural Highlights

  • Tricyclic Framework: The compound contains a tricyclo[9.4.0.03,8]pentadecane core, which is notable for its unique arrangement of carbon atoms in three interconnected cyclic structures.
  • Chloride Ion: As the chloride salt form, it underscores the significance of ionic interactions in stabilizing the molecular structure and enhancing solubility in various solvents.
  • Ammonium Group: The presence of the methyl-substituted ammonium group provides important links to biological activities, as many ammonium compounds display antimicrobial properties.

Applications and Importance

The unique structural characteristics of this compound allow it to potentially serve in various applications, such as:

  • Drug delivery systems where quaternary ammonium compounds are often utilized for their ability to facilitate transport across biological membranes.
  • Surface-active agents in formulations for pharmaceuticals, cosmetics, and detergents due to their amphiphilic properties, which help in emulsification or stabilization.
  • Research in material sciences exploring the unique mechanical and thermal properties imparted by the rigid tricyclic core.

The exploration of the synthesis and potential applications of methyl-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propyl]ammonium; chloride continues to intrigue scientists due to its complex architecture and the possibilities it presents in both academic research and practical applications. As highlighted by experts in the field, “The design of such compounds opens new avenues in targeted therapies and advanced material development.”

Synonyms
5H-Dibenzo(a,d)cycloheptene-5-propylamine, 10,11-dihydro-N-methyl-, hydrochloride
1750-07-8
LU 3-063
10,11-Dihydro-5-(3-methylaminopropyl)-5H-dibenzo(a,d)cycloheptene hydrochloride
5H-Dibenzo(a,d)cycloheptene, 10,11-dihydro-5-(3-methylaminopropyl)-, hydrochloride
DTXSID90169918
DTXCID0092409
methyl-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)propyl]azanium;chloride