Skip to main content

Methyl 3,4,5-trimethoxybenzoate

ADVERTISEMENT
Identification
Molecular formula
C11H14O5
CAS number
1916-07-0
IUPAC name
methyl 3,4,5-trimethoxybenzoate
State
State

At room temperature, methyl 3,4,5-trimethoxybenzoate is typically a solid.

Melting point (Celsius)
78.50
Melting point (Kelvin)
351.70
Boiling point (Celsius)
322.20
Boiling point (Kelvin)
595.40
General information
Molecular weight
212.22g/mol
Molar mass
212.2210g/mol
Density
1.1860g/cm3
Appearence

Methyl 3,4,5-trimethoxybenzoate appears as a colorless to pale yellow solid in its pure form. It can also exist in crystalline form and exhibits glossiness under light.

Comment on solubility

Solubility of Methyl 3,4,5-trimethoxybenzoate

Methyl 3,4,5-trimethoxybenzoate, with the chemical formula C12H16O5, exhibits interesting solubility characteristics:

  • Solvent Compatibility: This compound is generally soluble in organic solvents such as ethanol, ether, and chloroform.
  • Water Solubility: Methyl 3,4,5-trimethoxybenzoate has low solubility in water due to its nonpolar characteristics. As a general rule, "like dissolves like," and since water is polar, this compound does not dissolve well.
  • Temperature Effects: Solubility can be affected by temperature, and increasing the temperature typically enhances the solubility of organic compounds in solvents.
  • Structural Influences: The presence of three methoxy groups (-OCH3) contributes to its hydrophobic nature, making water solubility limited.

In summary, while Methyl 3,4,5-trimethoxybenzoate is moderately soluble in certain organic solvents, its solubility in water is considerably low, illustrating the fundamental chemical principle of solubility.

Interesting facts

Interesting Facts About Methyl 3,4,5-Trimethoxybenzoate

Methyl 3,4,5-trimethoxybenzoate is a fascinating compound with a variety of applications in the fields of organic chemistry and pharmacology. Here are some intriguing insights into this compound:

  • Structure and Functionality: The compound features three methoxy groups attached to a benzoate structure, making it a member of the broader family of methoxy-substituted benzoate esters. This unique arrangement contributes to its chemical reactivity and properties.
  • Natural Occurrence: This compound can be found in various plants and has been identified as a potential natural product with various biological activities. Its derivatives are often used for their therapeutic properties.
  • Applications in Synthesis: Methyl 3,4,5-trimethoxybenzoate is valuable in organic synthesis, particularly in the preparation of other chemical compounds. It's often utilized in cross-coupling reactions and can serve as an intermediate for more complex molecular structures.
  • Pharmaceutical Potential: Researchers are interested in this compound due to its possible implications in drug design. The presence of multiple methoxy groups can enhance the lipophilicity and bioavailability of pharmaceuticals.
  • Flavor and Fragrance: Due to its aromatic nature, methyl 3,4,5-trimethoxybenzoate is also explored in the fragrance industry. Its sweet and floral scent profile makes it appealing for use in perfumes and flavorings.

As a compound with diverse applications, methyl 3,4,5-trimethoxybenzoate exemplifies the rich possibilities that organic chemistry offers. Its blend of natural occurrence, synthetic utility, and potential pharmaceutical applications makes it an exciting subject for continued research.

Synonyms
Methyl 3,4,5-trimethoxybenzoate
1916-07-0
Trimethylgallic acid methyl ester
Methyl tri-O-methylgallate
3,4,5-Trimethoxybenzoic acid methyl ester
BENZOIC ACID, 3,4,5-TRIMETHOXY-, METHYL ESTER
3,4,5-Trimethoxybenzoic acid, methyl ester
QFP1LSC7TK
UNII-QFP1LSC7TK
EINECS 217-629-3
NSC 16955
BRN 2218156
AI3-21154
NSC-16955
Methyl gallate trimethyl ether
DTXSID0062058
4-10-00-01999 (Beilstein Handbook Reference)
TRIMETHOPRIM IMPURITY H [EP IMPURITY]
TRIMEBUTINE MALEATE IMPURITY C [EP IMPURITY]
TRIMETHOPRIM IMPURITY H (EP IMPURITY)
TRIMEBUTINE MALEATE IMPURITY C (EP IMPURITY)
DTXCID8036021
Methyl 3,4,5-trimethoxybenzoic acid
217-629-3
inchi=1/c11h14o5/c1-13-8-5-7(11(12)16-4)6-9(14-2)10(8)15-3/h5-6h,1-4h
kachfmohopltnx-uhfffaoysa-n
Methyl EudesMate
methyl 3,4,5-trimethoxy-d9-benzoate
1182838-07-8
Methyl 3,4,5-trimethoxy benzoate
Trimebutine Imp. C (EP); Trimethoprim Imp. H (EP); Methyl 3,4,5-Trimethoxybenzoate; Trimebutine Maleate Impurity C; Trimethoprim Impurity H
MFCD00008431
Trimethylgallicacidmethylester
Methyl 3,5-trimethoxybenzoate
SCHEMBL211747
CHEMBL1651039
CHEBI:192678
BCP18705
HY-N2044
NSC16955
BBL009653
s3863
STK401656
AKOS003283901
CCG-266765
FM25405
3,5-Trimethoxybenzoic acid methyl ester
Methyl 3,4,5-trimethoxybenzoate, 98%
3,5-Trimethoxybenzoic acid, methyl ester
AC-11227
AC-34705
AS-60488
DA-58738
Benzoic acid,4,5-trimethoxy-, methyl ester
CS-0018534
NS00026249
T1092
D70529
EN300-1228933
AC-907/25014289
AF-684/30328043
Q27287238
Z18364264
F0001-0689
3,4,5-Trimethoxybenzoic acid methyl ester;Methyl eudesmate;Methyl gallate trimethyl ether