Skip to main content

Atorvastatin

ADVERTISEMENT
Identification
Molecular formula
C33H34FN2O5
CAS number
134523-00-5
IUPAC name
methyl 4-[[2-[[2-[2-[(3-chloro-1-isopropyl-2-oxo-propyl)carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-4-oxo-butanoate
State
State

Atorvastatin calcium is typically found in a solid state at room temperature as it is formulated into tablets for use as a medication. When not in a combination product, the pure compound is a crystalline powder.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
760.00
Boiling point (Kelvin)
1 033.15
General information
Molecular weight
558.64g/mol
Molar mass
1 209.4240g/mol
Density
1.2000g/cm3
Appearence

Atorvastatin calcium appears as a white to off-white crystalline powder. It is often formualted into tablets for its role in treatments.

Comment on solubility

Solubility of Methyl 4-[[2-[[2-[2-[(3-chloro-1-isopropyl-2-oxo-propyl)carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-4-oxo-butanoate

The solubility of the compound with the chemical formula C33H34FN2O5 is an interesting topic, particularly due to the complexity and size of its molecular structure. Several factors influence its solubility, including:

  • Molecular structure: The presence of functional groups can affect how the compound interacts with solvents. For instance, the carbamate group may enhance solubilization in polar solvents.
  • Polarity: With multiple nitrogen and oxygen atoms, the polarity of the molecule could lead to better solubility in polar solvents such as water.
  • Hydrogen bonding: Potential for hydrogen bonding due to amine and carbonyl groups can further improve solubility in specific solvents.

Moreover, temperature can play a crucial role in solubility. Generally, an increase in temperature tends to increase the solubility of organic compounds. While the solubility data for this specific compound may not be extensively documented, it can be *hypothesized* that:

  1. It may exhibit moderate solubility in organic solvents like methanol or ethanol.
  2. It could be poorly soluble in non-polar solvents due to its polar functional groups.
  3. Solubility might vary significantly under different pH conditions, particularly if any acidic or basic conditions can affect ionization.

In summary, the solubility of this compound is likely influenced by its intricate structure, the presence of polar functional groups, and environmental factors such as solvent polarity and temperature. Therefore, exploring these aspects is essential for predicting practical applications of this compound in various fields.

Interesting facts

Interesting Facts about Methyl 4-[[2-[[2-[2-[(3-chloro-1-isopropyl-2-oxo-propyl)carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-4-oxo-butanoate

Methyl 4-[[2-[[2-[2-[(3-chloro-1-isopropyl-2-oxo-propyl)carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-4-oxo-butanoate is an intricate compound that epitomizes the complexity of modern synthetic chemistry. This compound showcases an interesting blend of structural motifs typical of pharmaceuticals, highlighting the importance of molecular design in drug development. Here are some captivating aspects:

  • Therapeutic Potential: Compounds like this are often investigated for their use in the treatment of various diseases, including cancer and neurodegenerative disorders.
  • Complexity: The molecule features multiple functional groups, such as amines and carbonyls, which may contribute to its biological activity and selectivity.
  • Structural Variety: With various interconnected rings and substituents, studying this compound can involve advanced analytical methods, including NMR, mass spectrometry, and X-ray crystallography.
  • Synthetic Pathways: The synthesis of such compounds often requires sophisticated multi-step protocols, showcasing the ingenuity of synthetic chemists.
  • Research Applications: This compound can serve as a lead compound in drug development, helping researchers to optimize pharmacological properties through structure-activity relationship (SAR) studies.

As noted by chemist and author A. Pauli, "The beauty of synthetic chemistry lies not just in the structure of compounds we create but in the potential they hold for advancing human health." This particular compound exemplifies that sentiment perfectly.

Overall, the study of methyl 4-[[2-[[2-[2-[(3-chloro-1-isopropyl-2-oxo-propyl)carbamoyl]pyrrolidin-1-yl]-1-methyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]amino]-4-oxo-butanoate opens doors to new explorations in medicinal chemistry and pushes the boundaries of what synthetic compounds can achieve.

Synonyms
Elastase Inhibitor III
MeOSuc-Ala-Ala-Pro-Val-Chloromethylketone
SCHEMBL21581232
PD118842
G92494