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Methyl 4-fluorobutanoate

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Identification
Molecular formula
C5H9FO2
CAS number
453-18-9
IUPAC name
methyl 4-fluorobutanoate
State
State

Methyl 4-fluorobutanoate is a liquid at room temperature.

Melting point (Celsius)
-71.00
Melting point (Kelvin)
202.15
Boiling point (Celsius)
129.00
Boiling point (Kelvin)
402.15
General information
Molecular weight
120.12g/mol
Molar mass
120.1240g/mol
Density
1.0453g/cm3
Appearence

Methyl 4-fluorobutanoate is a colorless liquid with a slightly sweet, fruity odor. It is typically clear and free from particulate matter.

Comment on solubility

Solubility of Methyl 4-Fluorobutanoate

Methyl 4-fluorobutanoate, with the chemical formula C5H9F O2, exhibits interesting solubility behavior due to its unique molecular structure. This compound is primarily characterized by its esterefic functionality and the presence of a fluorine atom, which can influence its interactions with various solvents. Here are key points regarding its solubility:

  • Polar Nature: The electronegative fluorine atom contributes to a degree of polarity in the molecule, which can enhance solubility in polar solvents such as water.
  • Miscibility: Methyl 4-fluorobutanoate is generally more miscible in organic solvents like ethanol and acetone, often due to the hydrophobic alkyl chain.
  • Temperature Effects: As is common with many organic compounds, solubility can increase with temperature, making heating a useful strategy in selected applications.
  • Solvent Selection: To maximize solubility, it's advisable to consider solvents with similar properties; for example, using solvents that are moderately polar could yield better results.

In summary, while methyl 4-fluorobutanoate demonstrates a notable solubility profile, its behavior is best understood through a careful examination of the solvent matrix and temperature conditions. The balance between its polar and nonpolar characteristics makes it versatile in various applications.

Interesting facts

Interesting Facts about Methyl 4-Fluorobutanoate

Methyl 4-fluorobutanoate is a fascinating compound in the field of organic chemistry, particularly due to its unique structural characteristics and diverse applications. Here are some captivating aspects of this compound:

  • Fluorine's Role: The presence of a fluorine atom in the compound introduces specific electronic properties, influencing its reactivity and the nature of the chemical bonds. Fluorinated compounds often exhibit enhanced biological activity.
  • Synthesis: Methyl 4-fluorobutanoate can be synthesized through various methods, one of which involves the reaction of 4-fluorobutyric acid with methanol in the presence of a catalyst, showcasing the importance of selective reactions in organic synthesis.
  • Applications: This compound is utilized extensively in the development of pharmaceuticals and agrochemicals, serving as an intermediate in the synthesis of various bioactive molecules.
  • Significance in Research: Its unique structure makes methyl 4-fluorobutanoate a valuable compound for researchers studying fluorinated compounds and their influence on biological systems.
  • Potential in Drug Design: The modification of molecules by fluorination, such as in methyl 4-fluorobutanoate, has been shown to improve the pharmacokinetic properties of drugs, making them more effective.

In summary, methyl 4-fluorobutanoate exemplifies the intricate balance between structure and functionality in medicinal chemistry. As a scientist or student delving into the world of organic compounds, understanding fluorinated derivatives like this offers profound insights into molecular behavior and reactivity. As the famous chemist Linus Pauling once said, "The best way to have a good idea is to have lots of ideas." Exploring compounds like methyl 4-fluorobutanoate certainly opens the door to innovative ideas and possibilities!

Synonyms
methyl 4-fluorobutanoate
4-Fluorobutyric acid methyl ester
406-20-2
BUTYRIC ACID, 4-FLUORO-, METHYL ESTER
Methyl 4-fluorobutyrate
Methyl gamma-fluorobutyrate
Methylester kyseliny 4-fluormaselne [Czech]
TL 1095
BRN 1744847
Methylester kyseliny 4-fluormaselne
DTXSID80193606
AKOS006277681