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Camptothecin

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Identification
Molecular formula
C20H16N2O4
CAS number
7689-03-4
IUPAC name
methyl 4-hydroxy-2,8-dimethyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrrolo[3,2-e]indole-2-carboxylate
State
State

At room temperature, camptothecin is typically found in a solid state, often handled as a fine powder for practical applications.

Melting point (Celsius)
267.00
Melting point (Kelvin)
540.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
348.35g/mol
Molar mass
348.3530g/mol
Density
1.4500g/cm3
Appearence

Camptothecin is characterized as a pale yellow solid. Its crystalline structure and appearance can vary with different forms of the compound.

Comment on solubility

Solubility of Methyl 4-hydroxy-2,8-dimethyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrrolo[3,2-e]indole-2-carboxylate

The compound methyl 4-hydroxy-2,8-dimethyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrrolo[3,2-e]indole-2-carboxylate, represented by the formula C20H16N2O4, exhibits a nuanced solubility profile that is crucial for its applications in chemical and pharmaceutical contexts.

Here are some key points regarding its solubility:

  • Polarity: The presence of hydroxyl (-OH) groups and carbonyl (C=O) functionalities suggests that the compound may have moderate polarity, which can enhance its solubility in polar solvents.
  • Solvent Compatibility: **Expected solubility** in organic solvents like methanol, ethanol, and DMSO, with potentially limited water solubility due to its hydrophobic regions.
  • Concentration Effects: At lower concentrations, the compound may dissolve more readily, while increasing concentration could lead to precipitation or decreased solubility due to intermolecular attraction.
  • pH Influence: The solubility might also be influenced by pH; in alkaline conditions, deprotonation of hydroxyl groups could enhance solubility, whereas acidic conditions could lead to protonation and reduced solubility.

Overall, a deeper understanding of the solubility of this compound can be facilitated through experimentation and interaction with various solvents, providing insights into its behavior in different environments.

Interesting facts

Interesting Facts about Methyl 4-Hydroxy-2,8-Dimethyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-7,8-Dihydro-3H-pyrrolo[3,2-e]indole-2-carboxylate

This complex organic compound holds a lot of potential in the realm of medicinal chemistry and organic synthesis. Here are some intriguing aspects:

  • Natural Product Inspiration: The structure of this compound is reminiscent of naturally occurring alkaloids, which often exhibit significant biological activity. Compounds like indole derivatives are known for their roles in various pharmacological applications.
  • Potential Therapeutic Uses: Given its structural complexity, this compound may have applications in drug design, particularly in developing therapies aimed at neurological disorders or cancer.
  • Synthetic Challenges: The synthesis of such a compound involves multiple steps, which can be challenging. Each functional group can introduce different reactivity and may require specific conditions to achieve the desired product.
  • Molecular Diversity: The presence of multiple methyl groups and methoxy substituents can significantly influence the biological activity of the compound. This highlights the importance of molecular diversity in organic compounds and its impact on their functionality.
  • Research Opportunities: With ongoing research into derivatives of indole and pyrrolo[3,2-e]indole frameworks, this compound provides an excellent opportunity for chemists to explore new derivatives and their potential activities.

Overall, methyl 4-hydroxy-2,8-dimethyl-1-oxo-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-7,8-dihydro-3H-pyrrolo[3,2-e]indole-2-carboxylate stands out as a fascinating subject of study that bridges the gap between organic synthesis and medicinal chemistry, opening doors to innovative discoveries.