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Methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate

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Identification
Molecular formula
C12H7ClN2O3
CAS number
3887-87-4
IUPAC name
methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate
State
State

The compound is a solid at room temperature, typically found in its crystalline form. It should be handled with care.

Melting point (Celsius)
235.00
Melting point (Kelvin)
508.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
266.65g/mol
Molar mass
266.6610g/mol
Density
1.4400g/cm3
Appearence

Methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate appears as a light yellow crystalline powder. The compound is stable under normal conditions and should be stored in a cool, dry place.

Comment on solubility

Solubility of Methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate

The solubility of methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate in various solvents can vary greatly, influenced by its structural features.

Here are some key points regarding its solubility:

  • Polarity: This compound contains both aromatic and polar functional groups, which suggests that it may have solubility in polar solvents, such as water and alcohols, as well as in non-polar solvents.
  • Hydrogen bonding: The carboxylate group can participate in hydrogen bonding, enhancing solubility in polar environments. However, the overall solubility may be limited due to the bulky oxazoloquinoline structure.
  • Solvent compatibility: When exploring solubility, common solvents to consider include:
    • Water
    • Dimethyl sulfoxide (DMSO)
    • Acetone
    • Ethyl acetate
  • Temperature influence: As with many organic compounds, increasing temperature may enhance solubility, particularly in non-polar solvents.

In summary, the solubility profile of methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate presents a complex interaction of its functional groups, making it an intriguing compound for further study in various solvent systems.

Interesting facts

Interesting Facts about Methyl 5-Chlorooxazolo[4,5-h]quinoline-2-carboxylate

Methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate is a fascinating compound in the realm of organic chemistry, primarily due to its unique structural features and potential applications. Here are some intriguing insights:

  • Versatile Building Block: This compound serves as a versatile precursor in the synthesis of various biologically active molecules. Its oxazoloquinoline framework is of particular interest in pharmaceutical chemistry.
  • Antimicrobial Potential: Research has indicated that compounds with similar structures may exhibit antimicrobial properties, making this compound a candidate for further investigation in the development of new antibiotics.
  • Research Interest: The quinoline derivatives are extensively studied for their **antimalarial**, **anticancer**, and **antiviral** properties, making this compound's derivatives a valuable focus for medicinal chemistry.
  • Environmental Relevance: The chlorinated compounds often have implications in environmental chemistry, especially concerning their persistence and bioaccumulation potential in ecosystems.

As one studies this compound, the question often arises: “How can we harness the unique properties of methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate to create more effective therapeutic agents?” This inquiry reflects a growing interest in utilizing such compounds in innovative ways to tackle pressing health challenges.


By delving deeper into the chemical interactions and biological activities of this compound, researchers hope to unlock new pathways in *drug discovery* and *development*, paving the way for the next generation of essential pharmaceuticals.

Synonyms
QUAZOLAST
86048-40-0
RHC 3988
methyl 5-chloro-[1,3]oxazolo[4,5-h]quinoline-2-carboxylate
methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate
RHC-3988
N8K2307472
Methyl 5-chlorooxazolo(4,5-h)quinoline-2-carboxylate
Quazolastum
Oxazolo(4,5-h)quinoline-2-carboxylic acid, 5-chloro-, methyl ester
Quazolastum [Latin]
Quazolast [USAN:INN]
UNII-N8K2307472
QUAZOLAST [INN]
Quazolast (USAN/INN)
QUAZOLAST [USAN]
CHEMBL23811
SCHEMBL635540
DTXSID10235366
CHEBI:177663
ZCRBUWNCWCWRGL-UHFFFAOYSA-N
BCP29744
EX-A3765
AKOS040747325
TS-08450
HY-106083
CS-0024816
NS00127136
D05670
Q27284707
RHC 3988; RHC-3988; RHC3988;5-COQCAM
2-Carbomethoxy-5-chloro-1,3-oxazolo-[4,5-h] quinoline
2-Carbomethoxy-5-chloro-1,3-oxazolo-[4,5-h]quinoline
5-chloro-1,3-oxazolo(4,5-h)quinoline-2-carboxylic acid methyl ester