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Mebendazole hydrochloride

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Identification
Molecular formula
C16H14ClN3O3
CAS number
35457-04-0
IUPAC name
methyl N-(1H-benzimidazol-3-ium-2-yl)carbamate;chloride
State
State

Mebendazole hydrochloride is a solid at room temperature, usually encountered as a crystalline powder.

Melting point (Celsius)
288.50
Melting point (Kelvin)
561.65
Boiling point (Celsius)
405.00
Boiling point (Kelvin)
678.15
General information
Molecular weight
327.78g/mol
Molar mass
327.7780g/mol
Density
1.4600g/cm3
Appearence

Mebendazole hydrochloride typically appears as an off-white to pale yellow crystalline powder. It is finely divided and presents a uniform texture.

Comment on solubility

Solubility of Methyl N-(1H-benzimidazol-3-ium-2-yl)carbamate;chloride

The solubility of methyl N-(1H-benzimidazol-3-ium-2-yl)carbamate;chloride is an intriguing aspect of this compound, influenced by its unique structure and ionic character. In general, the solubility behavior can be summarized as follows:

  • Polar Nature: This compound possesses polar functional groups, which often leads to greater solubility in polar solvents such as water.
  • Hydrochloride Salt Formation: As a hydrochloride salt, it tends to enhance solubility compared to its base form, allowing for better interaction with water molecules.
  • Temperature Dependence: The solubility may increase with temperature; thus, it is advisable to assess its behavior across different thermal conditions.
  • pH Sensitivity: Given that the compound contains benzimidazolium moieties, its solubility may vary significantly with changes in pH, forming either soluble or insoluble species based on protonation states.

In conclusion, while the solubility of methyl N-(1H-benzimidazol-3-ium-2-yl)carbamate;chloride is generally favorable in aqueous environments, the specifics can vary widely based on environmental factors. As always, ''experimental verification is essential'' to confirm solubility claims under various conditions.

Interesting facts

Interesting Facts about Methyl N-(1H-benzimidazol-3-ium-2-yl)carbamate; Chloride

Methyl N-(1H-benzimidazol-3-ium-2-yl)carbamate; chloride is an intriguing compound known for its diverse applications, particularly in the fields of pharmaceuticals and agrochemicals.

Key Highlights:

  • Biological Significance: This compound is studied for its potential antimicrobial properties, making it a candidate for the development of novel antibiotics.
  • Mechanism of Action: Its interaction with biological systems often involves *inhibition of enzymatic activity*, which is crucial for the growth of certain pathogens.
  • Versatile Applications: Beyond medicine, it has been explored as a pesticide due to its efficiency in targeting pests while minimizing harm to beneficial organisms.
  • Research Potential: The compound serves as a model for drug design, enabling researchers to modify its structure for improved efficacy and reduced side effects.

In the realm of chemistry, the synthesis of this compound showcases intricate methodologies and the importance of substitution patterns in influencing biological activity. As emphasized by chemists, *"the structure-activity relationship is key in drug discovery,"* highlighting how slight changes can lead to significant differences in performance.

Furthermore, advances in analytical techniques have allowed scientists to better understand the behavior and interaction of methyl N-(1H-benzimidazol-3-ium-2-yl)carbamate; chloride at a molecular level, paving the way for more targeted and effective therapeutic strategies.

Synonyms
Carbamic acid, 1H-benzimidazol-2-yl-, methyl ester, hydrochloride
2-BENZIMIDAZOLECARBAMIC ACID, METHYL ESTER, HYDROCHLORIDE