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Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate

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Identification
Molecular formula
C16H13N3O3S
CAS number
1214-39-7
IUPAC name
methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate
State
State

The compound is a solid at room temperature, often being found in a crystalline form.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.20
Boiling point (Celsius)
542.70
Boiling point (Kelvin)
815.90
General information
Molecular weight
327.36g/mol
Molar mass
327.3420g/mol
Density
1.3500g/cm3
Appearence

The compound typically appears as a solid. The appearance could be crystalline depending on the purity and the specific conditions in which it is stored.

Comment on solubility

Solubility of Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate

The solubility of methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate (C16H13N3O3S) can be influenced by several factors due to its complex structure. Understanding its solubility characteristics is crucial for applications in pharmaceuticals and material science.

Generally, the solubility of such compounds can be assessed through the following aspects:

  • Polarity: The presence of polar functional groups such as carbamate and carbonyl moieties may enhance solubility in polar solvents, such as water or alcohols.
  • Hydrophobic regions: The thiophene and benzimidazole rings contribute to hydrophobic interactions, which can lead to low solubility in water but higher solubility in organic solvents.
  • pH Sensitivity: The ionization of the carbamate group under various pH conditions may significantly impact solubility, making it more soluble in basic conditions.
  • Temperature effects: As with many organic compounds, solubility often increases with temperature, so elevated temperatures may facilitate better dissolution.

"Solubility is a key factor in drug formulation and environmental chemistry," and understanding the various influences can lead to better applications and performance of the compound.

In summary, while the compound methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate may exhibit varying solubility based on its environment, it is a compound that warrants further investigation to fully elucidate its solubility characteristics in different solvents and conditions.

Interesting facts

Interesting Facts about Methyl N-[6-(Thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate

Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate is a fascinating compound that showcases the intricate interplay between organic chemistry and pharmaceutical applications. Here are some engaging insights about this compound:

  • Structural Diversity: This compound is characterized by a unique combination of a benzimidazole ring and a thiophene moiety, which contributes to its biological activity and versatility in medicinal chemistry.
  • Biological Relevance: Compounds like this one are often investigated for their potential as antimicrobial agents, reflecting the importance of heterocyclic systems in drug discovery.
  • Mechanistic Insights: The presence of a carbamate group plays a crucial role in the property of the compound, influencing its reactivity and interactions within biological systems.
  • Synthetic Interest: The synthesis of this compound can often involve multi-step processes, showcasing the creativity and precision required in organic synthesis. Researchers are continually seeking more efficient methods to create similar compounds.
  • Research Application: Molecules similar to methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate are frequently explored for their potential as anticancer agents, which could lead to the development of novel therapeutic strategies.

In conclusion, methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate represents not only a captivating structure but also a window into the vast possibilities of organic and medicinal chemistry. As research continues, compounds like this one may pave the way for innovative health solutions in the future.

Synonyms
nocodazole
31430-18-9
Oncodazole
Nocodazol
Nocodazolum
R 17934
Nocidazole
Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate
NSC 238159
NSC-238159
R 17,934
methyl (5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-yl)carbamate
Nocodazole [USAN:INN]
Nocodazol [INN-Spanish]
Nocodazolum [INN-Latin]
C14H11N3O3S
Methyl 5-(2-thenoyl)-2-benzimidazolecarbamate
R-17934
Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate
Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
EINECS 250-626-5
NSC238159
NSC 238 159
SH1WY3R615
Methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate
N-(5-(2-Thenoyl)-2-benzimidazolyl)carbamic acid methyl ester
DTXSID9031800
CHEBI:34892
2-Benzimidazolecarbamic acid, 5-(2-thienylcarbonyl)-, methyl ester
NOCODAZOLE [INN]
2-Benzimidazolecarbamic acid, 5-(2-thenoyl)-, methyl ester
Methyl (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)carbamate
MFCD00005588
NOCODAZOLE [USAN]
CHEMBL9514
Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester
Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazole-2-yl)-, methyl ester
MLS001164242
DTXCID7011800
methyl (6-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-yl)carbamate
NCGC00015647-05
SMR000326904
N-(5-(2-Thienoyl)-2-benzimidazolyl)carbamic acid methyl ester
CAS-31430-18-9
METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMIDAZOL-2YL)CARBAMATE
Nocodazol (INN-Spanish)
Nocodazolum (INN-Latin)
[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester
Methyl 5-(2-thienoyl)-2-benzimidazolecarbamate
R17,934
2-Benzimidazolecarbamic acid, 5-(2-thienoyl)-, methyl ester
N-[5-(2-Thenoyl)-2-benzimidazolyl]carbamic acid methyl ester
Methyl [5-(2-thienylcarbonyl)-1H- benzimidazol-2-yl]carbamate
methyl [6-(thiophen-2-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate
methyl N-[5-(thiophene-2-carbonyl)-1H-1,3-benzodiazol-2-yl]carbamate
methyl N-[5-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate
(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester
Carbamic acid, [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester
R17934
SR-01000075979
UNII-SH1WY3R615
Nococazole
Methyl(5-(2-thienylcarbonyl))-1H-benzimidazole-2-yl carbamate
Methyl[5-(2-thienylcarbonyl)]-1H-benzimidazole-2-yl carbamate
N-[5-(2-Thienoyl)-2-benzimidazolyl]carbamic acid methyl ester
Nocodazole?
methyl N-(5-(thiophene-2-carbonyl)-1H-1,3-benzodiazol-2-yl)carbamate
Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester (9CI)
Carbamic acid, [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester (9CI)
NZO
Prestwick_359
Tocris-1228
3ee2
Nocodazole (USAN/INN)
Prestwick0_000100
Prestwick1_000100
Prestwick2_000100
Prestwick3_000100
Spectrum3_001768
Spectrum4_001060
Lopac-M-1404
ChemDiv1_000089
Probes1_000012
Probes1_000176
Probes2_000086
Probes2_000148
UPCMLD-DP111
Cambridge id 5175348
cid_4122
SCHEMBL9477
Lopac0_000733
Oprea1_483899
Oprea1_741554
BSPBio_000060
BSPBio_000982
BSPBio_003235
CBDivE_004971
CBDivE_008428
KBioGR_000322
KBioGR_001360
KBioSS_000322
MLS000860046
BIDD:GT0494
SPECTRUM1503266
SPBio_001999
BPBio1_000066
UPCMLD-DP111:001
BCBcMAP01_000161
BDBM97233
HMS587E01
KBio2_000322
KBio2_002890
KBio2_005458
KBio3_000643
KBio3_000644
KBio3_002735
Bio1_000461
Bio1_000950
Bio1_001439
Bio2_000331
Bio2_000811
HMS1362B03
HMS1568C22
HMS1792B03
HMS1922O09
HMS1990B03
HMS2094G13
HMS2095C22
HMS2235E18
HMS3262C08
HMS3267F03
HMS3403B03
HMS3412A10
HMS3604E13
HMS3656J06
HMS3676A10
HMS3712C22
Pharmakon1600-01503266
BCP07558
EX-A5289
Tox21_110189
Tox21_500733
HB3999
NSC759882
s2775
STK832483
Nocodazole, >=99% (TLC), powder
AKOS000538825
AKOS015901529
Tox21_110189_1
API0003615
CCG-101240
CCG-208075
CP-0076
CS-1893
DB08313
FN12330
LP00733
NSC-759882
SB19455
SDCCGSBI-0050711.P003
IDI1_002086
QTL1_000062
SMP2_000261
NCGC00015647-01
NCGC00015647-02
NCGC00015647-03
NCGC00015647-04
NCGC00015647-06
NCGC00015647-07
NCGC00015647-08
NCGC00015647-09
NCGC00015647-10
NCGC00015647-11
NCGC00015647-12
NCGC00015647-13
NCGC00015647-14
NCGC00015647-15
NCGC00015647-18
NCGC00015647-33
NCGC00025058-01
NCGC00025058-02
NCGC00025058-03
NCGC00025058-04
NCGC00025058-05
NCGC00025058-06
NCGC00025058-07
NCGC00025058-08
NCGC00025058-09
NCGC00025058-10
NCGC00261418-01
AC-25615
HY-13520
NCI60_001911
SBI-0050711.P002
DB-351731
EU-0100733
N1138
NS00029092
SW102861-5
D05197
M 1404
Q2506092
SR-01000075979-1
SR-01000075979-3
SR-01000075979-6
SR-01000075979-9
BRD-K12539581-001-06-2
BRD-K12539581-001-14-6
BRD-K12539581-001-21-1
BRD-K12539581-001-22-9
BRD-K12539581-001-23-7
Methyl (5-(2-thienylcarbonyl))-1H-benzimidazol-2-yl
5-(2-THENOYL)-2-BENZIMIDAZOLECARBAMIC ACID METHYL ESTER
2-Benzimidazolecarbamic acid, 5-(2-thenoyl)-, methyl ester (8CI)
5-(2-THIENOYL)-2-BENZIMIDAZOLECARBAMIC ACID METHYL ESTER
methyl N-(6-thiophen-2-ylcarbonyl-1H-benzimidazol-2-yl)carbamate
N-[6-(2-thenoyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester
[[5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]]carbamic acid methyl ester
5-(2-THIENYLCARBONYL)-2-BENZIMIDAZOLECARBAMIC ACID METHYL ESTER
carbamic acid, [6-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester
Carbamic acid, N-[5-(2-thenoyl)-1H-benzimidazol-2-yl]-, methyl ester
METHYL (5-(2-THIENYLCARBONYL)-1H-BENZIMIDAZOLE-2-YL)CARBAMATE
METHYL N-[6-(2-THIENYLCARBONYL)-1H-1,3-BENZIMIDAZOL-2-YL]CARBAMATE
(5-(2-THIENYLCARBONYL)-1H-BENZIMIDAZOL-2-YL)CARBAMIC ACID METHYL ESTER
[5-(Thiophene-2-carbonyl)-1H-benzoimidazol-2-yl]-carbamic acid methyl ester
N-[6-[oxo(thiophen-2-yl)methyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester
250-626-5
NW6