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Methyl trifluoromethanesulfonate

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Identification
Molecular formula
C2H3F3O3S
CAS number
333-27-7
IUPAC name
methyl trifluoromethanesulfonate
State
State

Under standard conditions, methyl trifluoromethanesulfonate is in a liquid state. It is volatile and can emit fumes when exposed to the air.

Melting point (Celsius)
-30.00
Melting point (Kelvin)
243.15
Boiling point (Celsius)
106.00
Boiling point (Kelvin)
379.15
General information
Molecular weight
164.10g/mol
Molar mass
164.0920g/mol
Density
1.4290g/cm3
Appearence

Methyl trifluoromethanesulfonate is a colorless liquid. It is typically clear and can be slightly oily in texture due to its methyl ester content.

Comment on solubility

Solubility of Methyl Trifluoromethanesulfonate

Methyl trifluoromethanesulfonate, with the chemical formula CH3CF3SO3CH3, exhibits interesting solubility characteristics due to its unique molecular structure. This compound is generally soluble in a variety of solvents, which can be summarized as follows:

  • Organic Solvents: It is highly soluble in common organic solvents such as acetone, methanol, and dichloromethane.
  • Water: Methyl trifluoromethanesulfonate has a limited solubility in water. This is primarily due to the hydrophobic nature imparted by the trifluoromethyl group.
  • Polarity Influence: The solubility is considerably influenced by the polarity of the solvent. Polar solvents tend to dissolve this compound more effectively than non-polar ones.

As stated, “the solubility of a compound is a reflection of its molecular interactions,” which is particularly evident here. Understanding the solubility of methyl trifluoromethanesulfonate is crucial for its applications in chemical synthesis and industrial processes.


Interesting facts

Interesting Facts About Methyl Trifluoromethanesulfonate

Methyl trifluoromethanesulfonate is a fascinating compound that belongs to the category of sulfonates. Here are some key insights into its properties and applications:

  • Unique Structure: This compound features a trifluoromethanesulfonate functional group, which contributes to its reactivity. The presence of fluorine atoms makes it a strong electrophile.
  • Versatile Reagent: Methyl trifluoromethanesulfonate is widely utilized in organic synthesis, particularly as a reagent for various transformations. It is known for its ability to act as an effective methylating agent.
  • High Reactivity: Due to the electronegativity of the fluorine atoms, this compound can engage in nucleophilic substitution reactions, making it valuable in producing methyl ethers and other derivatives.
  • Role in Pharmaceutical Chemistry: In the pharmaceutical industry, it is employed for the synthesis of complex molecules. Its ability to add methyl groups efficiently is particularly advantageous in drug development.
  • Environmental Considerations: Given its fluoroalkyl nature, care must be taken in handling methyl trifluoromethanesulfonate due to potential environmental and health impacts. A comparison with similar compounds helps understand its behavior.

As one studies this compound, one might ponder the question: How does this compound compare to other sulfonate esters in reactivity? The chemistry of methyl trifluoromethanesulfonate not only showcases a rich field of study but also emphasizes the importance of careful application in scientific research and industry.

Synonyms
Methyl trifluoromethanesulfonate
333-27-7
Methyl triflate
Methyl trifluoromethanesulphonate
Methanesulfonic acid, trifluoro-, methyl ester
Methyl trifluoromethane sulfonate
MeOTf
CCRIS 1158
Trifluoromethanesulfonic Acid Methyl Ester
EINECS 206-371-7
UNII-7B25Z22EPV
NSC 270679
7B25Z22EPV
DTXSID6049272
AI3-62911
NSC-270679
DTXCID1029128
1,1,1-Trifluoromethanesulfonic acid methyl ester
Methanesulfonic acid, 1,1,1-trifluoro-, methyl ester
trifluoro-methanesulfonic acid methyl ester
METHYL TRIFLUOROMETHANESULFONATE [MI]
C2H3F3O3S
METHYLTRIFLUOROMETHANESULFONATE
methyltriflate
methyl trifiate
TfOMe
MFCD00000409
triflic acid methyl ester
CF3SO2OCH3
SCHEMBL38490
Methyl trifloromethanesulfonate
Methyl trifluoromethylsulfonate
methyltrifluoromethane sulfonate
methyl trifluoromethane-sulfonate
CHEMBL3185488
BCP22549
CS-B0882
Tox21_202914
FD2053
NSC270679
AKOS005063680
FM34989
trifluoro-methansulfonic acid methylester
Trifluoromethylsulfonic acid methyl ester
Methyl trifluoromethanesulfonate, >=98%
NCGC00260460-01
AS-18305
BP-21280
CAS-333-27-7
DB-030038
Methanesulfonic acid, trifluoro, methyl ester
NS00022063
T2029
EN300-62786
Q907614
Methanesulfonic acid, 1,1,1trifluoro, methyl ester
F1905-7179
Methyl trifluoromethanesulfonate, for GC derivatization, 98.0%