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Tacrine morpholino amide

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Identification
Molecular formula
C19H20N2O2
CAS number
157809-57-9
IUPAC name
morpholino(1,2,3,4-tetrahydroacridin-9-yl)methanone
State
State

The primary state of the compound at room temperature is a solid. It is stable under normal conditions and doesn't easily sublimate or liquefy without significant changes in temperature.

Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
486.00
Boiling point (Kelvin)
759.15
General information
Molecular weight
336.41g/mol
Molar mass
336.4090g/mol
Density
1.3738g/cm3
Appearence

The compound typically appears as a crystalline solid. It is often a pale yellow to beige powder, depending on purity and conditions. The appearance can also shift with chemical modifications and formulations.

Comment on solubility

Solubility of morpholino(1,2,3,4-tetrahydroacridin-9-yl)methanone

The solubility of morpholino(1,2,3,4-tetrahydroacridin-9-yl)methanone can be influenced by several factors, primarily its molecular structure and interactions with solvents. Here are some key points regarding its solubility:

  • Polarity: This compound exhibits a complex molecular framework, which may lead to varying degrees of polarity. Generally, compounds with polar functional groups tend to be more soluble in polar solvents like water, while those with nonpolar characteristics may dissolve better in organic solvents.
  • Solvent Compatibility: It may show solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), or acetone. The presence of the morpholino group can enhance interactions with polar solvents.
  • pH Dependence: The solubility can also be affected by the pH of the solution, as protonation of the morpholino nitrogen may impact its interactions with water.
  • Temperature Effects: Increasing temperature generally enhances solubility, though the effect can vary based on the specific interactions of the compound with the solvent.

Overall, the solubility of morpholino(1,2,3,4-tetrahydroacridin-9-yl)methanone depends intricately on its molecular characteristics and the solvent environment, reflecting the principle that "like dissolves like." Therefore, careful selection of solvent is crucial for optimal solubility and application of this compound.

Interesting facts

Interesting Facts About Morpholino(1,2,3,4-tetrahydroacridin-9-yl)methanone

Morpholino(1,2,3,4-tetrahydroacridin-9-yl)methanone is a fascinating compound that introduces a mix of unique structural elements and potential applications in various scientific fields. Here are some captivating details about this compound:

  • Versatile Structure: The compound features a morpholine ring, which is known for its flexibility and ability to act as a building block in organic synthesis. The incorporation of the tetrahydroacridine moiety enhances its structural diversity.
  • Potential Pharmacological Properties: Compounds containing the acridine backbone have been investigated for their biological activity, including anticancer, antiviral, and antimicrobial properties. This suggests that morpholino(1,2,3,4-tetrahydroacridin-9-yl)methanone may warrant exploration for therapeutic applications.
  • Research Interest: The introduction of a morpholine group often lends to improved solubility and bioavailability in biological systems, making such compounds attractive in drug design. Researchers continue to explore how modifications in the structure can optimize efficacy.
  • Mechanistic Insight: Understanding the interaction of morpholino(1,2,3,4-tetrahydroacridin-9-yl)methanone with biological targets could provide insights into its mechanism of action. This information is crucial for the development of novel therapies.
  • Use in Material Science: Beyond medicinal chemistry, compounds like this can have utility in materials science, potentially contributing to the development of novel organic materials and sensors.
  • Collaborative Research: This compound serves as a platform for interdisciplinary collaboration, bridging the gap between organic chemistry, biochemistry, and pharmacology.

In summary, morpholino(1,2,3,4-tetrahydroacridin-9-yl)methanone is not just a compound of interest due to its unique structure but also holds promise for various applications in research and development. Its multifaceted nature continues to inspire chemists to dig deeper and uncover its potential.

Synonyms
7157-29-1
KETONE, MORPHOLINO(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)
RZ6ZZW2TXI
4-Morpholinocarbonyl-2,3-tetramethylenequinoline
NSC 107326
BRN 1220916
Acridine, 1,2,3,4-tetrahydro-9-(morpholinocarbonyl)-
Acridine, 9-(morpholinocarbonyl)-1,2,3,4-tetrahydro-
UNII-RZ6ZZW2TXI
NSC-107326
Morpholine, 4-((1,2,3,4-tetrahydro-9-acridinyl)carbonyl)-
DTXSID40221797
Morpholino(1,2,3,4-tetrahydro-9-acridinyl) ketone
4-MORPHOLINYL(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)METHANONE
METHANONE, 4-MORPHOLINYL(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)-
DTXCID70144288
Morpholine, 4-((1,2,3,4-tetrahydro-9-acridinyl)carbonyl)-(8CI)
Morpholine, 4-((1,2,3,4-tetrahydro-9-acridinyl)carbonyl)-(8CI)(9CI)
morpholin-4-yl(1,2,3,4-tetrahydroacridin-9-yl)methanone
NSC107326
Oprea1_127689
Oprea1_360733
IFLab1_004946
CHEMBL4897003
MVDXQTJHPRBMOK-UHFFFAOYSA-N
HMS1426A18
AKOS000595603
Ketone,2,3,4-tetrahydro-9-acridinyl)
DS-015324
EU-0047434
Morpholine,2,3,4-tetrahydro-9-acridinyl)carbonyl]-
Z28251455
Acridine, 1,2,3,4-tetrahydro-9-(4-morpholylcarbonyl)-
9-(4-Morpholinylcarbonyl)-1,2,3,4-tetrahydroacridine #
Morpholine, 4-[(1,2,3,4-tetrahydro-9-acridinyl)carbonyl-