Lapatinib | Solubility of Things

Identification

Molecular formula

C₂₉H₂₆ClFN₄O₄S

CAS number

231277-92-2

IUPAC name

N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(2,4-dimethoxyphenyl)vinyl]benzamide

State

At room temperature, Lapatinib is a solid. It is handled as a powder for pharmaceutical formulation, offering stability and ease of transport.

Melting point (Celsius)

136.00

Melting point (Kelvin)

409.00

Boiling point (Celsius)

804.30

Boiling point (Kelvin)

1 077.45

General information

Molecular weight

581.06g/mol

Molar mass

581.0570g/mol

Density

1.4180g/cm³

Appearence

In its pure form, Lapatinib is a white to pale yellow powder. It is typically used in its tablet form when administered as a drug.

Comment on solubility

Solubility of N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(2,4-dimethoxyphenyl)vinyl]benzamide

The solubility of N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(2,4-dimethoxyphenyl)vinyl]benzamide in various solvents reflects its complex structure and chemical interactions. This compound is likely to demonstrate variable solubility based on the following factors:

Polarity: Given its bulky diethylamino and methoxyphenyl groups, solubility may be enhanced in organic solvents such as ethanol or methanol.
Temperature: Increased temperatures often lead to higher solubility for many organic compounds, including this one. Hence, heating a solvent could improve dissolving efficiency.
pH Dependence: As a compound with amine functionalities, its solubility may vary significantly with the pH of the solution, where ionization can occur under certain conditions.

Interestingly, this compound might present low solubility in water due to its hydrophobic regions, leading to a preference for non-polar solvents. Overall, as with many complex organic compounds, solubility behavior is a nuanced interplay of chemical structure and environmental conditions.

Interesting facts

Interesting Facts about N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(2,4-dimethoxyphenyl)vinyl]benzamide

N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(2,4-dimethoxyphenyl)vinyl]benzamide is a fascinating compound known for its multifaceted applications and intriguing structure. Here are some interesting aspects of this chemical:

Pharmacological Potential: This compound has been investigated for its potential in medicinal chemistry, particularly in the development of new therapeutic agents. It might hold promise in treating various ailments due to its unique molecular framework.
Complex Structure: The compound features a complex interplay of functional groups, including both an amino group and an amide bond. This complexity is intriguing for chemists, as it can lead to distinctive reactivity and interactions.
Vinyl Group: The presence of a vinyl group in its structure is particularly interesting; vinyl compounds often participate in different reactions like polymerization, making them valuable in materials science.
Dimethoxy Substitution: The incorporation of two methoxy groups on the aromatic ring introduces interesting electronic characteristics. This substitution can influence the compound’s reactivity and binding affinity in biological systems.
Potential for Novel Derivatives: Scientists are enthusiastic about the possibility of synthesizing novel derivatives based on this compound, which may lead to discovering even more potent active pharmaceutical ingredients.

As a student of chemistry, exploring such compounds opens up avenues for understanding the relationship between structure and biological activity. Researching N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(2,4-dimethoxyphenyl)vinyl]benzamide not only enhances our knowledge of organic compounds but also equips us with tools for future innovations in drug design and synthesis.