Etravirine | Solubility of Things

Identification

Molecular formula

C₂₀H₁₅BrClFN₅O₃

CAS number

269055-15-4

IUPAC name

N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(4-methoxyphenyl)vinyl]benzamide

State

At room temperature, Etravirine is typically in a solid state in the form of a crystalline powder.

Melting point (Celsius)

243.00

Melting point (Kelvin)

516.15

Boiling point (Celsius)

484.80

Boiling point (Kelvin)

757.90

General information

Molecular weight

435.56g/mol

Molar mass

435.5590g/mol

Density

1.1830g/cm³

Appearence

Etravirine is a white to light yellow powder. It is very slightly soluble in water but more soluble in organic solvents such as methanol or ethanol.

Comment on solubility

Solubility of N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(4-methoxyphenyl)vinyl]benzamide

N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(4-methoxyphenyl)vinyl]benzamide is a complex organic compound whose solubility characteristics are influenced by its intricate structure.

Factors Influencing Solubility:

Polarity: The presence of polar functional groups can increase solubility in polar solvents.
Hydrophobic regions: The hydrophobic aromatic rings may limit solubility in water but enhance solubility in organic solvents.
Alkyl chains: The diethylamino group can influence overall solubility by introducing hydrophobic character.
Temperature: Solubility can vary with temperature, often increasing in warmer conditions.

In general, this compound is expected to show better solubility in organic solvents such as ethanol or DMSO, while its solubility in water may be limited. As stated, “Like dissolves like”, which suggests that polar solvents are more effective in dissolving polar compounds, whereas non-polar solvents serve better for hydrophobic compounds.

Overall, this compound's solubility profile presents an interesting case for investigation in various solvents, particularly in the realm of pharmaceutical applications.

Interesting facts

Interesting Facts about N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(4-methoxyphenyl)vinyl]benzamide

N-[1-[2-(diethylamino)ethylcarbamoyl]-2-(4-methoxyphenyl)vinyl]benzamide is a fascinating compound that holds significant relevance in various scientific fields, especially medicinal chemistry. Here are some intriguing insights about this compound:

Complex Structure: This compound features a multi-functional structure that includes a diethylamino group and a methoxyphenyl vinyl moiety. Such diversity in its architecture often translates into unique chemical properties and biological activity.
Pharmaceutical Applications: Compounds with similar structural features have been investigated for their potential as therapeutic agents. The presence of the diethylamino group suggests potential interactions with biological systems, possibly enhancing water solubility and modulating biological activity.
Structure-Activity Relationship (SAR): The intricate design allows for the exploration of SAR in drug development. Scientists can modify specific parts of the molecule to evaluate how structural changes can influence efficacy and selectivity, which is crucial in optimizing drug candidates.
Mechanism of Action: Research specializes in understanding how such compounds interact at the molecular level with target proteins, which can lead to significant advancements in therapies for various diseases, including cancers and neurological disorders.
Research Opportunities: The chemical can serve as a valuable template for synthetic chemistry, prompting further exploration in the synthesis of novel derivatives that may exhibit improved pharmacological properties.

This compound exemplifies the intricate relationships between molecular structure and function, making it an exciting subject for ongoing research and exploration in the realm of chemistry and pharmacology.