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Amphotericin B

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Identification
Molecular formula
C47H73N3O17
CAS number
1397-89-3
IUPAC name
N-[1-(3-aminopropyl)-10-guanidino-2-hydroxy-decyl]-9-guanidino-nonanamide
State
State

At room temperature, Amphotericin B is in a solid state. It is typically found as a crystalline powder in its pure form.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
924.09g/mol
Molar mass
924.0910g/mol
Density
1.6800g/cm3
Appearence

Amphotericin B appears as a yellow to orange crystalline solid. It is commonly available as a lyophilized powder when used for pharmaceutical applications. In its pure form, it is insoluble in water, and thus it has various formulations for medical use to improve solubility.

Comment on solubility

Solubility of N-[1-(3-aminopropyl)-10-guanidino-2-hydroxy-decyl]-9-guanidino-nonanamide

This compound, known as N-[1-(3-aminopropyl)-10-guanidino-2-hydroxy-decyl]-9-guanidino-nonanamide, exhibits interesting properties regarding its solubility. The solubility of a compound often depends on a range of factors, including:

  • Polarity: The presence of multiple guanidino groups and hydroxyl groups typically suggests a degree of polarity, which may enhance solubility in polar solvents.
  • Hydrogen Bonding: The hydroxy group can engage in hydrogen bonding, significantly affecting how this compound interacts with water and other solvents.
  • Chain Length: The nonanamide structure may impart hydrophobic characteristics, potentially limiting solubility in highly polar environments.

Overall, it is reasonable to postulate that:

  • This compound is likely to be soluble in polar organic solvents and aqueous solutions due to its polar functional groups.
  • However, its solubility in pure water may be limited compared to more soluble simpler amino acids.

In essence, the solubility profile is influenced by a delicate balance of hydrophilic and hydrophobic interactions, making it a compound of significant interest in research applications.

Interesting facts

Compound Overview

The compound N-[1-(3-aminopropyl)-10-guanidino-2-hydroxy-decyl]-9-guanidino-nonanamide is a fascinating molecule that belongs to the class of guanidine derivatives. Its complex structure contributes to various biological activities, making it of significant interest in both pharmacology and medicinal chemistry.

Key Properties and Applications

  • Bioactivity: This compound exhibits a range of biological activities, primarily thanks to its guanidine functionality, which is known for its ability to interact with various biological targets.
  • Potential Uses: Research suggests potential applications in the treatment of various diseases, particularly those involving neuromodulation and metabolic disorders.
  • Innovative Research: Scientists are investigating the compound's capacity to act as a therapeutic agent in conditions such as diabetes and neurological disorders.

Chemical Significance

The intricate arrangement of functional groups within the molecule enhances its biological effectiveness. The presence of both guanidino and amino groups allows for:

  • Enhanced solubility: Important for drug delivery systems.
  • Target specificity: Increases the likelihood of safe and effective binding to biological receptors.

Quote of Interest

As noted in various studies, "Compounds with guanidine derivatives are at the forefront of modern drug development due to their versatile biological activities." This statement underscores the importance of ongoing research in this area.

In conclusion, N-[1-(3-aminopropyl)-10-guanidino-2-hydroxy-decyl]-9-guanidino-nonanamide is more than just a chemical compound; it represents the intersection of chemistry, biology, and the quest for innovative therapeutics. Understanding this compound opens doors to new possibilities in drug design and development.

Synonyms
Eulicin
534-76-9
BRN 1717786
N-[1-amino-13-(diaminomethylideneamino)-5-hydroxytridecan-4-yl]-9-(diaminomethylideneamino)nonanamide
Nonanamide, N-(1-(3-aminopropyl)-10-guanidino-2-hydroxydecyl)-9-guanidino-
4-04-00-02809 (Beilstein Handbook Reference)
Nonanamide, 9-((aminoiminomethyl)amino)-N-(10-((aminoiminomethyl)amino)-1-(3-aminopropyl)-2-hydroxydecyl)-
N-(1-amino-13-(diaminomethylideneamino)-5-hydroxytridecan-4-yl)-9-(diaminomethylideneamino)nonanamide
SCHEMBL6366112
DTXSID40968059
CHEBI:216292
N-[1-(3-aminopropyl)-10-guanidino-2-hydroxy-decyl]-9-guanidino-nonanamide
9-(Guanidino)-N-[10-(guanidino)-1-(3-aminopropyl)-2-hydroxydecyl]nonanamide
N-(1-Amino-13-carbamimidamido-5-hydroxytridecan-4-yl)-9-carbamimidamidononanimidic acid