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Fentanyl

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Identification
Molecular formula
C22H28FN3O
CAS number
437-38-7
IUPAC name
N-[[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-phenyl-4-piperidyl]methyl]acetamide
State
State

At room temperature, fentanyl is a solid. It has various medicinal formulations, including transdermal patches and injectable solutions, where it may be present in other states such as liquid solutions.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
234.00
Boiling point (Kelvin)
507.15
General information
Molecular weight
336.47g/mol
Molar mass
336.4690g/mol
Density
1.3350g/cm3
Appearence

Fentanyl is typically found as a white or off-white solid in pure form, but can exist as a powder, pill, or liquid when used in medical formulations.

Comment on solubility

Solubility of N-[[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-phenyl-4-piperidyl]methyl]acetamide

The solubility of N-[[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-phenyl-4-piperidyl]methyl]acetamide can be influenced by several factors, primarily its chemical structure and molecular interactions.

Factors Affecting Solubility:

  • Nature of Substituents: The presence of the fluorophenyl and piperidyl groups might enhance hydrophobic interactions, potentially leading to lower solubility in polar solvents.
  • Polarity of the Molecule: The acetamide functional group may impart some level of polarity, which could help in solubility in polar solvents like water.
  • Hydrogen Bonding: The capacity of the compound to form hydrogen bonds can significantly affect its dissolution behavior, enhancing solubility in certain environments.

In summary, while N-[[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-phenyl-4-piperidyl]methyl]acetamide may exhibit some degree of solubility due to its acetamide component, factors such as hydrophobic interactions and the overall molecular architecture could play a crucial role in determining its solubility profile. Thus, _the solubility behavior of this compound could be complex and context-dependent_.

Interesting facts

Interesting Facts about N-[[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-phenyl-4-piperidyl]methyl]acetamide

N-[[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-phenyl-4-piperidyl]methyl]acetamide is a compound of considerable interest in medicinal chemistry and pharmacology. Here are some intriguing points regarding this compound:

  • Pharmaceutical Relevance: This compound is a derivative of piperidine and represents a class of compounds that have shown potential therapeutic effects, making it a subject of investigation for various medical applications.
  • Fluorine Substitution: The presence of a fluorine atom in the structure significantly alters the electronic properties, which can enhance the binding affinity to biological targets. Fluorinated compounds often exhibit improved metabolic stability and reduced toxicity.
  • Complex Structure: With multiple functional groups and a piperidine ring, this compound's structure is considerably complex, affording diverse interactions with biological systems. This complexity often correlates with unique pharmacological profiles.
  • Potential Applications: Compounds with similar structures are frequently explored as potential treatments for conditions such as mood disorders, schizophrenia, or even neurodegenerative diseases. Research continues to unveil the diverse roles such compounds may play.

As a student or researcher, understanding the implications of molecular modifications—such as fluorination—can lead to innovative drug designs. The exploration of such compounds exemplifies the intersection of chemistry and medicine, showcasing how subtle changes can produce substantial biological effects.

In conclusion, N-[[1-[4-(4-fluorophenyl)-4-oxo-butyl]-4-phenyl-4-piperidyl]methyl]acetamide not only serves as an intriguing subject for chemical analysis but also offers a glimpse into the potential of modern pharmaceuticals derived from intricate organic compounds.

Synonyms
Aceperone
Acetabuton
807-31-8
ACETABUTONE
Aceperone [INN]
Aceperona
R 3248
NSC 170980
NSC-170980
4-(4-(Acetamidomethyl)-4-phenylpiperidino)-4'-fluorobutyrophenone
Aceperone;NSC 170980
S69KXZ59AB
N-[[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-phenylpiperidin-4-yl]methyl]acetamide
MLS003106752
CHEMBL136298
R-3248
N-(1-(3-(p-Fluorobenzoyl)propyl)-4-phenyl-4-piperidylmethyl)acetamide
Acetamide, N-[[1-[3-(p-fluorobenzoyl)propyl]-4-phenyl-4-piperidyl]methyl]-
Acetamide, N-[[1-[4-(4-fluorophenyl)-4-oxobutyl]-4-phenyl-4-piperidinyl]methyl]-
Aceperonum
Aceperonum [INN-Latin]
Aceperona [INN-Spanish]
Acetamide, N-((1-(4-(4-fluorophenyl)-4-oxobutyl)-4-phenyl-4-piperidinyl)methyl)-
UNII-S69KXZ59AB
BRN 0500391
4-[4-(Acetamidomethyl)-4-phenylpiperidino]-4'-fluorobutyrophenone
ACEPERONE [MI]
N-(1-(3-(4-Fluorbenzoyl)propyl)-4-phenyl-4-piperidylmethyl)acetamid
5-22-09-00505 (Beilstein Handbook Reference)
SCHEMBL2732714
DTXSID30230510
VDGZERMDPAAZEJ-UHFFFAOYSA-N
BDBM50133938
NSC170980
Acetamide, N-(1-(3-(p-fluorobenzoyl)propyl)-4-phenyl-4-piperidylmethyl)-
AKOS040750051
SMR001821640
NS00003312
Q4673090
N-[1-(4-p-Fluorophenyl-4-oxobutyl)-4-phenyl-4-piperidinylmethyl] acetamide
N-((1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-phenyl-4-piperidinyl)methyl)acetamide #
N-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-4-phenyl-piperidin-4-ylmethyl}-acetamide