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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
N-[1-(4-chlorophenyl)-2-methyl-2-(1-piperidyl)propylidene]benzamide
State
State

At room temperature, Loperamide is typically found in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
744.91
Boiling point (Kelvin)
1 018.06
General information
Molecular weight
477.03g/mol
Molar mass
477.0330g/mol
Density
1.2680g/cm3
Appearence

Loperamide is generally available as white to off-white crystalline powder. It may be odorless or possess a faint odor.

Comment on solubility

Solubility of N-[1-(4-chlorophenyl)-2-methyl-2-(1-piperidyl)propylidene]benzamide

The solubility of N-[1-(4-chlorophenyl)-2-methyl-2-(1-piperidyl)propylidene]benzamide raises interesting considerations for its application in various chemical processes and formulations. Its unique structure suggests specific solubility characteristics:

  • Polarity: The presence of a benzamide functional group tends to increase polar interactions, potentially enhancing solubility in polar solvents.
  • Hydrophobic effects: The chlorophenyl and piperidyl groups contribute to hydrophobic characteristics, which could limit solubility in highly polar solvents while favoring non-polar media.
  • Solvent compatibility: Solubility is likely to be higher in organic solvents such as ethanol or dimethyl sulfoxide (DMSO), rather than in aqueous solutions.

As a result, it can be crucial to consider the solvent system when anticipating the solubility behavior of this compound. Furthermore, understanding its solubility profile can facilitate:

  1. Optimization of drug formulation
  2. Improved bioavailability in pharmacological applications
  3. Effective synthesis processes in organic chemistry

In conclusion, while N-[1-(4-chlorophenyl)-2-methyl-2-(1-piperidyl)propylidene]benzamide may demonstrate solubility tendencies from both polar and non-polar perspectives, its practical applications will heavily rely on the choice of appropriate solvents to achieve desired concentrations.

Interesting facts

Interesting Facts About N-[1-(4-chlorophenyl)-2-methyl-2-(1-piperidyl)propylidene]benzamide

N-[1-(4-chlorophenyl)-2-methyl-2-(1-piperidyl)propylidene]benzamide is a compound that showcases interesting connections between organic chemistry and pharmacology. Here are some notable facts:

  • Pharmacological Significance: This compound belongs to a class of substances that may exhibit biological activity, making it of interest in the development of pharmaceutical agents.
  • Structure and Function: The unique structure, characterized by the presence of a piperidine ring, contributes to its potential activity as a ligand, which can bind to specific receptors in biological systems.
  • Synthetic Pathways: The synthesis of compounds like this typically involves various organic transformations. Understanding the synthetic routes not only hones skill in laboratory techniques but also enhances comprehension of reaction mechanisms.
  • Chlorine's Role: The inclusion of a chlorine atom in the 4-position of the phenyl ring can significantly influence the compound's solubility and interaction with biological targets, emphasizing the importance of halogen substituents in organic compounds.
  • Research Potential: This compound presents opportunities for further research into its potential therapeutic effects, as well as studies into its pharmacokinetics and toxicology.

As a fascinating example of the interplay between structure and activity, N-[1-(4-chlorophenyl)-2-methyl-2-(1-piperidyl)propylidene]benzamide embodies the challenges and rewards of chemical research. It serves as a reminder that even complex compounds like this can lead to significant advancements in medicine and understanding of molecular interactions.