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Levocetirizine Dihydrochloride

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Identification
Molecular formula
C21H27Cl2N2O
CAS number
130018-77-8
IUPAC name
N-[1-(4-chlorophenyl)-2-methyl-2-piperidin-1-ium-1-yl-propylidene]benzamide;chloride
State
State

Levocetirizine Dihydrochloride is typically found as a solid at room temperature, existing in a crystalline powder form.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
388.91g/mol
Molar mass
388.9100g/mol
Density
1.0493g/cm3
Appearence

Levocetirizine Dihydrochloride is a white to off-white powder. It is known for being film-coated and is often found in tablet form when used pharmaceutically.

Comment on solubility

Solubility of N-[1-(4-chlorophenyl)-2-methyl-2-piperidin-1-ium-1-yl-propylidene]benzamide;chloride

The solubility of N-[1-(4-chlorophenyl)-2-methyl-2-piperidin-1-ium-1-yl-propylidene]benzamide;chloride can be influenced by several factors, including its molecular structure and the presence of functional groups. Generally, this compound is expected to exhibit moderate to good solubility in polar solvents such as water and alcohols, while demonstrating limited solubility in non-polar solvents.

Key points to consider regarding its solubility include:

  • Ionization: The presence of the chloride ion may enhance solubility in aqueous environments due to ion-dipole interactions.
  • Polarity: The piperidine ring introduces a relatively polar aspect, facilitating interactions with water molecules.
  • Hydrophobic characters: The aromatic and chloro-substituted groups may tend to resist solubility in highly polar solvents.

In summary, the solubility behavior of this compound can be viewed as a balance between its polar and non-polar characteristics. The interplay of its ionic and nonionic features makes it suited for diverse solvent systems, enhancing its applicability in various chemical contexts.

Interesting facts

Interesting Facts about N-[1-(4-chlorophenyl)-2-methyl-2-piperidin-1-ium-1-yl-propylidene]benzamide; chloride

N-[1-(4-chlorophenyl)-2-methyl-2-piperidin-1-ium-1-yl-propylidene]benzamide; chloride is a fascinating chemical compound due to its unique structural features and biological implications. Here are some noteworthy points:

  • Pharmacological Interest: This compound exhibits properties that have drawn attention in the pharmaceutical field, particularly for its potential therapeutic applications related to neurological disorders.
  • Structure Diversity: The presence of both a piperidine ring and a chlorophenyl moiety contributes to its diverse reactivity and interaction patterns, making it interesting for medicinal chemistry.
  • Ion Exchange Behavior: As a chloride salt, it showcases interesting behavior in ionic environments, which may affect its solubility and reactivity in various organic syntheses.
  • Potential Interactions: The dual regions of polarity and non-polarity within the molecule can lead to fascinating interactions with biological membranes, influencing its transport and bioavailability.
  • Historical Significance: Compounds of this nature often serve as lead compounds in the development of new drugs, with many derivatives being synthesized for enhanced efficacy.

As scientists explore the pharmacodynamic properties of this compound, it is poised to inspire future research. Additionally, its complex molecular architecture provides numerous avenues for derivatives and modifications, allowing chemists to create tailored molecules with specific effects and reduced side effects. The ongoing study of such compounds underlines the dynamic nature of medicinal chemistry and the quest for innovative solutions to health challenges.

Synonyms
Benzamide, N-(p-chloro-alpha-(1-methyl-1-piperidinoethyl)benzilidene)-, monohydrochloride
16297-40-8
N-(p-Chloro-alpha-(1-methyl-1-piperidinoethyl)benzilidene) benzamide monohydrochloride