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N-(1-adamantyl)pyridine-4-carboxamide

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Identification
Molecular formula
C16H21N2O
CAS number
3806-30-6
IUPAC name
N-(1-adamantyl)pyridine-4-carboxamide
State
State

At room temperature, N-(1-adamantyl)pyridine-4-carboxamide is a solid. It has a relatively high melting point, indicating its solid state is stable under standard conditions.

Melting point (Celsius)
219.00
Melting point (Kelvin)
492.15
Boiling point (Celsius)
433.00
Boiling point (Kelvin)
706.15
General information
Molecular weight
264.36g/mol
Molar mass
264.3830g/mol
Density
1.2010g/cm3
Appearence

This compound typically appears as a white crystalline solid. Its crystalline structure provides high stability and distinct morphology.

Comment on solubility

Solubility of N-(1-adamantyl)pyridine-4-carboxamide

N-(1-adamantyl)pyridine-4-carboxamide exhibits interesting solubility characteristics, influenced by its unique molecular structure. Here are some key points to consider:

  • Polarity: The compound shows a combination of polar and nonpolar regions, which can affect its solubility in various solvents.
  • Solvent Compatibility: It is generally soluble in polar aprotic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), while showing limited solubility in water due to its hydrophobic adamantane group.
  • Temperature Effects: Solubility can vary with temperature; typically, higher temperatures may enhance solubility in organic solvents.
  • Influence of Substituents: The presence of substituents like the adamantyl group may enhance interaction with nonpolar solvents.

In summary, while N-(1-adamantyl)pyridine-4-carboxamide is not highly soluble in water, it finds better solubility in polar organic solvents. Its unique structure contributes to its intriguing solubility profile.

Interesting facts

Interesting Facts about N-(1-adamantyl)pyridine-4-carboxamide

N-(1-adamantyl)pyridine-4-carboxamide is a fascinating compound that merges the structural characteristics of adamantane with pyridine, creating a compound with unique properties and applications. Here are some noteworthy insights:

  • Structural Diversity: This molecule presents an interesting combination of a rigid adamantyl group and the flexible pyridine ring. This fusion may lead to interesting conformations and electronic properties.
  • Biological Significance: Compounds containing pyridine rings are often associated with biological activity. N-(1-adamantyl)pyridine-4-carboxamide may exhibit intriguing pharmacological properties, making it a candidate for further research in medicinal chemistry.
  • Chemical Reactivity: The presence of a carboxamide functional group can influence the molecule's reactivity. This functional group is known for its role in hydrogen bonding, potentially enhancing the compound's interaction with biological systems.
  • Research Potential: The unique structure presents opportunities for synthesis and study, which may enhance our understanding of structure-activity relationships in drug design.
  • Diversity in Applications: Given its structural features, N-(1-adamantyl)pyridine-4-carboxamide may find applications not only in pharmaceuticals but also in agrochemicals or as intermediates in organic synthesis.

As chemists continue to explore such compounds, N-(1-adamantyl)pyridine-4-carboxamide stands out for its blend of rigidity and flexibility, potentially leading to a wealth of new discoveries.

Synonyms
N-(1-Adamantyl)isonicotinamide
24813-24-9
BRN 0407137
ISONICOTINAMIDE, N-(1-ADAMANTYL)-
DTXSID10179514
RefChem:349634
DTXCID70102005
N-(tricyclo[3.3.1.1~3,7~]dec-1-yl)pyridine-4-carboxamide
N-(1-adamantyl)pyridine-4-carboxamide
SCHEMBL16872821
STK049859
AKOS003856298
Z27687054