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N-(1-benzyl-3-chloro-2-oxo-propyl)-4-methyl-benzenesulfonamide

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Identification
Molecular formula
C17H18ClNO3S
CAS number
42905-08-0
IUPAC name
N-(1-benzyl-3-chloro-2-oxo-propyl)-4-methyl-benzenesulfonamide
State
State

At room temperature, N-(1-benzyl-3-chloro-2-oxo-propyl)-4-methyl-benzenesulfonamide is typically in a solid state.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
351.85g/mol
Molar mass
351.8470g/mol
Density
1.3500g/cm3
Appearence

The compound generally appears as a white to off-white solid. Its physical form can vary from a crystalline powder to a more amorphous solid.

Comment on solubility

Solubility of N-(1-benzyl-3-chloro-2-oxo-propyl)-4-methyl-benzenesulfonamide

The solubility of N-(1-benzyl-3-chloro-2-oxo-propyl)-4-methyl-benzenesulfonamide in various solvents can be quite fascinating and is influenced by several structural components. Here are some key points regarding its solubility:

  • Organic Solvents: This compound is likely to have increased solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and acetone due to its hydrophobic benzene rings.
  • Aqueous Solubility: The presence of the sulfonamide functional group may enhance solubility in water to some extent; however, the overall hydrophobic nature can limit its solubility.
  • Temperature Dependence: Solubility often varies with temperature; thus, a solubility test at elevated temperatures may reveal increased solubility.
  • pH Influence: The solubility of this compound may also be affected by the pH of the solution. Changes in pH can alter the ionization state of the sulfonamide group, potentially improving solubility in aqueous environments versus neutral conditions.

In summary, while N-(1-benzyl-3-chloro-2-oxo-propyl)-4-methyl-benzenesulfonamide may exhibit some degree of solubility in polar solvents, its overall solubility profile is likely dictated by its complex structure. Understanding the solubility behaviors not only aids in predicting its use in various applications but also informs the development of formulations and delivery methods in medicinal chemistry.

Interesting facts

Interesting Facts about N-(1-benzyl-3-chloro-2-oxo-propyl)-4-methyl-benzenesulfonamide

N-(1-benzyl-3-chloro-2-oxo-propyl)-4-methyl-benzenesulfonamide is a fascinating compound that showcases the intricate world of organic chemistry. Its unique structure features a sulfonamide group, which has significant implications in biochemistry and medicinal chemistry.

  • Pharmaceutical Relevance: Sulfonamides were among the first antibiotics discovered and remain important in various therapeutic applications. This compound could potentially serve as a lead structure for developing new drugs.
  • Unique Functional Groups: The presence of both a ketone and a sulfonamide moiety lends to the compound's intriguing reactivity. Such groups can participate in various chemical reactions, making the compound versatile in synthetic pathways.
  • Structural Insights: The substituents attached to the benzene ring and the alkyl chain contribute to the compound's biological activity. Scientists often study such modifications to enhance potency and selectivity in drug design.
  • Research Potential: Due to its structure, this compound may offer opportunities for further research. Its activity against specific pathogens or its role in inhibiting certain biological pathways could open new avenues in pharmacology.

Furthermore, the intricate balance of functional groups in N-(1-benzyl-3-chloro-2-oxo-propyl)-4-methyl-benzenesulfonamide makes it a prime candidate for studies in structure-activity relationships (SAR). As researchers explore the diverse chemistry surrounding this compound, the ongoing questions regarding its application in medicine and industry continue to inspire innovations in chemical research.

Synonyms
329-30-6
N-(3-Chloro-2-oxo-1-(phenylmethyl)propyl)-4-methylbenzenesulfonamide
n-(4-chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzenesulfonamide
1-chloro-3-tosylamido-4-phenyl-2-butanone
Tos-Phe-chloromethylketone
MFCD00000935
NSC 89167
Tosylphenylalanyl chloromethyl ketone, (L)-
SCHEMBL441444
T.P.C.K.
DTXSID20926571
NPE1244
MQUQNUAYKLCRME-UHFFFAOYSA-N
Tosyl-L-phenylalanyl-chloromethane
NSC89167
NSC-89167
AKOS024370910
Benzenesulfonamide, N-(3-chloro-2-oxo-1-(phenylmethyl)propyl)-4-methyl-
Tosyl-L-Phenylalanine chloromethylketone
tosyl-l-phenylalanyl chloromethyl ketone
LS-14569
NCI60_041981
SY075507
NS00043751
(S)-1-Chloro-3-tosylamido-4-phenyl-2-butanone
(S)-1-Chloro-4-phenyl-3-tosylamido-2-butanone
N-(4-Chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzene-1-sulfonamide
130021-38-4