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Ethosuximide

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Identification
Molecular formula
C7H11NO2
CAS number
77-67-8
IUPAC name
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide
State
State

Solid at room temperature.

Melting point (Celsius)
57.00
Melting point (Kelvin)
330.15
Boiling point (Celsius)
379.80
Boiling point (Kelvin)
652.95
General information
Molecular weight
141.17g/mol
Molar mass
141.1600g/mol
Density
1.3400g/cm3
Appearence

Ethosuximide is typically a white crystalline solid.

Comment on solubility

Solubility of N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide

N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide, with the chemical formula C7H11NO2, exhibits intriguing solubility characteristics that are influenced by its molecular structure.

Key Points about Solubility:

  • Polar and Non-Polar Balance: Due to the presence of both polar groups (sulfamoyl and methoxy) and a relatively hydrophobic aromatic system, the solubility in water can vary.
  • Solvent Choice: This compound is likely to be more soluble in polar organic solvents such as methanol or ethanol, owing to its functional groups.
  • Temperature Dependency: Like many organic compounds, its solubility may increase with temperature; hence testing at various temperatures could yield additional insights.
  • pH Influence: The solubility can be affected by the pH of the solution, especially due to the presence of sulfonamide groups, which may ionize at different pH levels.

In summary, while comprehensive solubility data for N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide may be limited, the interplay of its polar and non-polar aspects suggests a potential for moderate solubility, particularly in suitable organic solvents. Always consider experimental validation for precise solubility determinations.

Interesting facts

Interesting Facts about N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide

This intriguing compound, N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide, is full of scientific significance and potential applications. Here are some engaging insights into this chemical:

  • Structural Complexity: The molecule features a unique combination of a pyrrolidine ring and a sulfonamide group, contributing to its distinctive chemical behavior. The presence of a methoxy group adds to the diversity of functional groups, allowing for varied reactivity.
  • Pharmacological Potential: Compounds similar to this one often demonstrate significant biological activity. The combination of a benzamide and sulfonamide moiety has been known to interact with various biological targets, hinting at potential pharmaceutical applications.
  • Organic Synthesis: The intricate structure of N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide highlights its importance in organic synthesis. Chemists often explore ways to create such complex molecules as a means to develop new materials or therapeutic agents.
  • Research Focus: This compound can be a subject of research in identifying its interaction with specific biological pathways, potentially leading to new treatments for diseases. The study of similar derivatives could yield insights into pharmacokinetics and toxicity.
  • Interdisciplinary Applications: Beyond medicinal chemistry, this compound could also have implications in fields like materials science or environmental chemistry, showcasing how a single chemical can bridge multiple disciplines.

In conclusion, the exploration of N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide not only exemplifies the beauty of complex organic compounds but also opens avenues for innovative research and development in various scientific fields. As with many compounds in chemistry, the journey of discovery is as exciting as the destination.

Synonyms
sulpiride
15676-16-1
Sulpyrid
(+/-)-Sulpiride
Sulpirid
Dolmatil
Aiglonyl
Dogmatil
Dogmatyl
Guastil
Miradol
Mirbanil
Misulvan
Omperan
Splotin
Sursumid
Abilit
Dobren
Meresa
Coolspan
Sernevin
Neogama
(RS)-(+/-)-sulpiride
Pyrkappl
Eglonyl
Calmoflorine
Championyl
Lisopiride
Stamonevrol
Alimoral
Darleton
Desmenat
Dresent
Eglonil
Equilid
Eusulpid
Fardalan
Fidelan
Isnamide
Kylistro
Mariastel
Norestran
Nufarol
Ozoderpin
Restful
Sulpirida
Sulpitil
Suprium
Valirem
Zemorcon
Enimon
Normum
Omiryl
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Pyrikappl
Sulpiridum
Synedil
Sulpiridum [INN-Latin]
Sulpirida [INN-Spanish]
Sulpor
dl-sulpiride
RD 1403
N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide
CCRIS 4248
5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide
R.D. 1403
N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide
EINECS 239-753-7
(+-)-sulpiride
UNII-7MNE9M8287
BRN 0494008
DTXSID1042574
CHEBI:32168
N05AL01
7MNE9M8287
Benzamide, 5-(aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-
Magnetic resonance imaging sulpiride
CHEMBL26
MFCD00055061
Psicocen
o-Anisamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-
NSC-757850
RD-1403
rac Sulpiride
C15H23N3O4S
DTXCID9022574
n-((1-ethylpyrrolidin-2-yl)methyl)-2-methoxy-5-sulfamoylbenzamide
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide
5-22-08-00105 (Beilstein Handbook Reference)
Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-
NSC 757850
Sulperide
Sulpiridum (INN-Latin)
Sulpirida (INN-Spanish)
SULPIRIDE (MART.)
SULPIRIDE [MART.]
Sulpiride-R
SULPIRIDE (EP IMPURITY)
SULPIRIDE [EP IMPURITY]
SULPIRIDE (EP MONOGRAPH)
SULPIRIDE [EP MONOGRAPH]
(+)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide
SMR000038923
SULPIRIDE,(+)
Sulpiride [USAN:INN:BAN:JAN]
SR-01000075402
CCRIS-4248
(y)-Sulpiride
Sulpiride, SLP
(plusmn)-sulpiride
Dogmatyl (TN)
(?)-Sulpiride
Prestwick_431
CAS-15676-16-1
Sulpiride (Standard)
PS30 - Sulpiride
SULPIRIDE [INN]
SULPIRIDE [JAN]
SULPIRIDE [MI]
SULPIRIDE [USAN]
(.+/-.)-Sulpiride
Prestwick0_000056
Prestwick1_000056
Prestwick2_000056
Prestwick3_000056
SULPIRIDE,(-)
Biomol-NT_000037
Biomol-NT_000162
SCHEMBL8421
SULPIRIDE [WHO-DD]
Lopac0_001050
Oprea1_602476
BSPBio_000211
MLS000069434
MLS001306443
DivK1c_000278
SPBio_002132
BPBio1_000233
BPBio1_000463
BPBio1_001255
GTPL5501
Sulpiride (JP18/USAN/INN)
BDBM11638
HMS500N20
HY-B1019R
KBio1_000278
NINDS_000278
Sulpiride 1.0 mg/ml in Methanol
HMS1568K13
HMS2095K13
HMS2231K07
HMS3263A22
HMS3266P12
HMS3371P16
HMS3372O01
HMS3393A08
HMS3411D18
HMS3651G12
HMS3675D18
HMS3712K13
HMS3885J14
BCP04500
BCP13871
HY-B1019
STR09321
( inverted question mark)-Sulpiride
Tox21_302205
Tox21_501050
HB1835
s4655
STK368596
5-(Aminosufonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
AKOS004912732
CCG-205127
CS-4534
DB00391
FS27973
LP01050
SDCCGSBI-0051020.P002
( inverted exclamation markA)-Sulpiride
IDI1_000278
NCGC00015966-03
NCGC00015966-04
NCGC00015966-05
NCGC00015966-06
NCGC00015966-07
NCGC00015966-08
NCGC00015966-16
NCGC00024852-02
NCGC00024852-03
NCGC00024852-04
NCGC00024852-05
NCGC00255813-01
NCGC00261735-01
AC-12181
DB-046215
EU-0001755
EU-0101050
NS00010476
R. D. 1403
D01226
S 8010
EN300-2010446
L000579
Q422418
SR-01000075402-2
SR-01000075402-3
SR-01000075402-6
BRD-A55272860-001-03-9
BRD-A55272860-001-04-7
BRD-A55272860-001-08-8
BRD-A55272860-001-14-6
BRD-A55272860-001-15-3
Z84655412
Sulpiride, British Pharmacopoeia (BP) Reference Standard
1-ethyl-2-(2-methoxy-5-sulfamoylbenzamidomethyl)pyrrolidine
Sulpiride, European Pharmacopoeia (EP) Reference Standard
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoyl-benzamide
N-(1-Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide
(+/-)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
(+/-)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide
N-(1-ETHYL-2-PYRROLIDINYLMETHYL)-2-METHOXY-5-SULFAMIDOBENZAMIDE
(+/-)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
(RS)-(+/-)-5-Aminosulfonyl-N-[(1-ethyl -2-pyrrolidinyl)methyl]-2-methoxybenzamide
( inverted question mark)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
239-753-7
5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-benzamide ;N-(1-Ethyl-2-pyrrolidinylmethyl)-2-methoxy-5-sulfamidobenzamide