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Celecoxib

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Identification
Molecular formula
C17H14F3N3O2S
CAS number
169590-42-5
IUPAC name
N-[1-(hydrazinecarbonyl)-2-methyl-3-phenyl-propyl]acetamide
State
State

Solid: At room temperature, celecoxib is in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
445.80
Boiling point (Kelvin)
718.95
General information
Molecular weight
381.37g/mol
Molar mass
381.3720g/mol
Density
1.2030g/cm3
Appearence

Celecoxib is a white to off-white crystalline powder. It is hydrophobic and practically insoluble in water, slightly soluble in methanol, and freely soluble in tetrahydrofuran.

Comment on solubility

Solubility of N-[1-(hydrazinecarbonyl)-2-methyl-3-phenyl-propyl]acetamide

N-[1-(hydrazinecarbonyl)-2-methyl-3-phenyl-propyl]acetamide is an intriguing compound with unique solubility characteristics. Understanding its solubility is crucial for various applications, including pharmacological studies and chemical syntheses.

The solubility behavior of this compound can be influenced by several factors:

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents, while non-polar components may lead to solubility in organic solvents.
  • Temperature: Increased temperature can often result in higher solubility for many compounds; thus, conducting solubility tests at various temperatures may yield important insights.
  • pH Levels: The ionization state of the compound may vary depending on the pH of the solution, impacting solubility significantly.
  • Solvent Interaction: The choice of solvent plays a pivotal role, where solvents like water, ethanol, or dimethyl sulfoxide (DMSO) might exhibit different solubility parameters.

In practical terms, “solubility is not just a mere fact, but an intricate dance of molecular interactions”. It’s essential to conduct a thorough solubility assessment under standard conditions to evaluate the compound's appropriate applications in research and industry.

Therefore, a comprehensive study will help determine the optimal conditions for dissolving N-[1-(hydrazinecarbonyl)-2-methyl-3-phenyl-propyl]acetamide, providing valuable data for its effective use in scientific endeavors.

Interesting facts

Interesting Facts about N-[1-(Hydrazinecarbonyl)-2-methyl-3-phenyl-propyl]acetamide

N-[1-(Hydrazinecarbonyl)-2-methyl-3-phenyl-propyl]acetamide is a fascinating compound that showcases the intricate relationship between structure and biological activity. Here are some notable aspects of this compound:

  • Dual Functionality: This compound serves as a versatile building block in medicinal chemistry, primarily due to the presence of both hydrazine and acetamide functionalities, which are known for their reactivity and ability to form multiple derivatives.
  • Biological Significance: Compounds that contain hydrazine moieties are explored for their potential anti-tumor and anti-inflammatory properties, placing this compound in a promising position for pharmaceutical applications.
  • Synthetic Pathways: The synthesis of N-[1-(hydrazinecarbonyl)-2-methyl-3-phenyl-propyl]acetamide can be achieved through various methods, allowing chemists to tailor the synthesis based on desired yields and environmental considerations.
  • Structure-Activity Relationship: Research on similar compounds emphasizes the importance of the hydrazinecarbonyl group, which can significantly enhance the bioactivity of the molecule it is attached to, leading to new drug discovery opportunities.
  • Research Potential: With ongoing studies in the fields of organic and medicinal chemistry, compounds like N-[1-(hydrazinecarbonyl)-2-methyl-3-phenyl-propyl]acetamide are continually investigated for new therapeutic avenues, especially in developing treatments for challenging diseases.

In summary, N-[1-(hydrazinecarbonyl)-2-methyl-3-phenyl-propyl]acetamide is an intriguing compound that holds promise in pharmaceuticals due to its multifaceted structure and potential biological implications. As research progresses, it can pave the way for further innovations in drug design and therapy.

Synonyms
N-Acetylglycine 2-(alpha-methylphenethyl)hydrazide
3314-09-8
BRN 0671891
DTXSID10954762
GLYCINE, N-ACETYL-, 2-(alpha-METHYLPHENETHYL)HYDRAZIDE
N-(1-Hydrazinylidene-1-hydroxy-3-methyl-4-phenylbutan-2-yl)ethanimidic acid