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Albendazole

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Identification
Molecular formula
C12H15N3O2S
CAS number
54965-21-8
IUPAC name
N-[1-(hydroxymethyl)-2-(methylsulfanylmethylsulfinyl)ethyl]-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enamide
State
State

At room temperature, albendazole is in a solid state. This characteristic is typical for many compounds used in pharmaceutical applications. The stability of its crystalline form is essential for its use in medications.

Melting point (Celsius)
207.00
Melting point (Kelvin)
480.00
Boiling point (Celsius)
570.00
Boiling point (Kelvin)
843.00
General information
Molecular weight
265.33g/mol
Molar mass
265.3340g/mol
Density
1.3372g/cm3
Appearence

Albendazole appears as a white to pale yellow, odorless crystalline powder. It is visually characterized by its fine particulate texture and off-white hue, which may vary slightly depending on sample purity.

Comment on solubility

Solubility of N-[1-(hydroxymethyl)-2-(methylsulfanylmethylsulfinyl)ethyl]-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enamide

The compound N-[1-(hydroxymethyl)-2-(methylsulfanylmethylsulfinyl)ethyl]-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enamide exhibits intriguing solubility characteristics, which are influenced by its complex structure. Understanding its solubility is essential for various applications in pharmaceuticals and material sciences.

Key Factors Influencing Solubility:

  • Polarity: The presence of hydroxymethyl and sulfinyl groups contributes to the overall polarity of the compound, potentially enhancing solubility in polar solvents.
  • Hydrogen Bonding: The hydroxymethyl group may partake in hydrogen bonding with solvents, promoting solubility in aqueous solutions.
  • Molecular Interactions: Interactions between the various functional groups can affect solubility; for instance, the presence of sulfonate may interact favorably with polar solvents.

It is important to consider solubility as a dynamic feature that can vary with:

  • Temperature: Higher temperatures may enhance solubility due to increased molecular motion.
  • pH Levels: The ionization state of the compound can alter its solubility profile, especially in aqueous environments.

In summary, while the solubility of this compound can be expected to be moderate to high in polar solvents, specific experimental conditions must be explored to determine its precise behavior. As such, a thorough investigation into its solubility is warranted for practical applications.

Interesting facts

Interesting Facts about N-[1-(hydroxymethyl)-2-(methylsulfanylmethylsulfinyl)ethyl]-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enamide

This compound encompasses a fascinating blend of structural features and potential applications, making it a subject of interest in the field of pharmaceutical chemistry. Here are some notable points:

  • Biodiversity and Natural Products: The compound contains a pyrimidine ring, which is a crucial component in various biological molecules, including nucleotides and nucleic acids. Its presence highlights the intricate connections between synthetic chemistry and natural biological processes.
  • Antioxidant Properties: The molecule features a hydroxymethyl group, which can enhance its antioxidant capabilities. Compounds with antioxidant properties are sought after for their potential health benefits, including reducing oxidative stress in cells.
  • Sulfur Chemistry: The inclusion of methylsulfanylmethylsulfinyl groups brings in fascinating sulfur chemistry. Sulfur-containing compounds often exhibit unique reactivity and biological activity, making them essential in medicinal chemistry.
  • Potential Applications: Due to the diverse functional groups in the compound, it may possess interesting pharmacological activities. These might include antiviral, antibacterial, or anticancer potential, necessitating further investigation through biological assays.
  • Synthesis Complexity: The synthesis of such complex molecules typically requires innovative approaches in organic synthesis, showcasing the creativity and ingenuity of chemists in designing multifunctional compounds.
  • Structural Diversity: The intricate structure not only emphasizes the versatility of organic molecules but also opens avenues for modification and derivatives that could lead to enhanced bioactivity or specificity.

In conclusion, N-[1-(hydroxymethyl)-2-(methylsulfanylmethylsulfinyl)ethyl]-3-(6-methyl-2,4-dioxo-1H-pyrimidin-5-yl)prop-2-enamide stands as a testament to the intricate relationship between structure and function in chemistry, with promising avenues for research and application in the medical field.

Synonyms
Neuro_000026
BAA40464
SMP2_000117