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Bupivacaine

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Identification
Molecular formula
C18H28N2O
CAS number
2180-92-9
IUPAC name
N-[1-methyl-1-(p-tolyl)ethyl]-2-(propylamino)acetamide
State
State

Bupivacaine is in a solid state at room temperature.

Melting point (Celsius)
107.50
Melting point (Kelvin)
380.65
Boiling point (Celsius)
347.50
Boiling point (Kelvin)
620.65
General information
Molecular weight
288.43g/mol
Molar mass
288.4350g/mol
Density
1.0120g/cm3
Appearence

Bupivacaine is typically a white crystalline powder. It is odorless and slightly soluble in water, but highly soluble in ethanol, methanol, and chloroform. The compound is often used in the form of its hydrochloride salt for medical applications.

Comment on solubility

Solubility of N-[1-methyl-1-(p-tolyl)ethyl]-2-(propylamino)acetamide

The solubility of N-[1-methyl-1-(p-tolyl)ethyl]-2-(propylamino)acetamide can be influenced by various factors such as temperature, pH, and the presence of other solutes. In general, amides tend to exhibit moderate solubility in water due to their ability to engage in hydrogen bonding. Here are some key points regarding the solubility of this compound:

  • Polarity: As a sub-entity of the amide functional group, the presence of the acetamide moiety contributes to the compound's overall polarity, likely enhancing its solubility in polar solvents.
  • Hydrophobic Groups: The p-tolyl and propylamino groups introduce hydrophobic characteristics, which may reduce solubility in water while potentially increasing solubility in organic solvents.
  • Temperature Dependency: Increased temperature generally increases solubility for many compounds, suggesting that heating may improve the dissolution of this compound in solvents.
  • pH Influence: The solubility can also vary with pH levels, as charge states can change for the amine group at different pH levels, affecting water solubility.

In summary, the solubility of N-[1-methyl-1-(p-tolyl)ethyl]-2-(propylamino)acetamide is a complex interplay of its functional groups and environmental conditions. It is advisable to conduct specific solubility tests under varying conditions for a more accurate assessment of its solubility profile.

Interesting facts

Interesting Facts about N-[1-methyl-1-(p-tolyl)ethyl]-2-(propylamino)acetamide

N-[1-methyl-1-(p-tolyl)ethyl]-2-(propylamino)acetamide is a fascinating compound that belongs to the class of amides, which play significant roles in both medicinal chemistry and industrial processes. Here are some intriguing aspects of this compound:

  • Pharmaceutical Applications: This compound can be explored for its potential therapeutic uses, particularly in the development of new medications that target specific biological pathways.
  • Structure-Activity Relationship: The structural modifications in this compound can lead to variations in biological activity, making it an excellent subject for studying how small changes in chemical structure can affect function.
  • Imparting Selectivity: The presence of the p-tolyl and propylamino groups in the structure may enhance the selectivity towards certain receptors, potentially making it useful in the design of selective drugs.
  • Research Potential: This compound serves as a fundamental building block in organic synthesis, paving the way for the generation of other complex molecules and derivatives.
  • Synergy in Chemistry: The combination of the methyl, p-tolyl, and propylamino substitutions contributes to the unique properties of the thus derived molecules, showcasing the creativity required in synthetic chemistry.

In conclusion, N-[1-methyl-1-(p-tolyl)ethyl]-2-(propylamino)acetamide is not just a simple chemical compound; it is a gateway to exploring various aspects of chemistry, including drug design, organic synthesis, and the intricate relationships between molecular structure and biological activity. As research in this area progresses, compounds like this may lead to breakthroughs in therapeutic agents and our understanding of chemical functionality.

Synonyms
GEA 679
BRN 2940554
ACETAMIDE, 2-(PROPYLAMINO)-N-(alpha,alpha,p-TRIMETHYLBENZYL)-
2-(Propylamino)-N-(alpha,alpha,p-trimethylbenzyl)acetamide
26187-17-7
DTXSID40180815
Acetamide, N-(1-methyl-1-(4-methylphenyl)ethyl)-2-(propylamino)-
RefChem:314661
DTXCID80103306
SCHEMBL29657118