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Pirfenidone

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Identification
Molecular formula
C12H11NO2
CAS number
53179-13-8
IUPAC name
N-[1-methyl-2-(1-piperidyl)ethyl]-N-(2-pyridyl)propanamide
State
State

At room temperature, pirfenidone is a solid. It is typically stable in solid form and is not volatile at standard conditions.

Melting point (Celsius)
105.00
Melting point (Kelvin)
378.00
Boiling point (Celsius)
426.90
Boiling point (Kelvin)
700.10
General information
Molecular weight
185.22g/mol
Molar mass
185.2400g/mol
Density
1.1620g/cm3
Appearence

Pirfenidone is a white to pale yellow solid. It may appear as a crystalline powder or granules.

Comment on solubility

Solubility of N-[1-methyl-2-(1-piperidyl)ethyl]-N-(2-pyridyl)propanamide

N-[1-methyl-2-(1-piperidyl)ethyl]-N-(2-pyridyl)propanamide, with its complex structure, has a solubility profile influenced by both its polar and non-polar characteristics. Understanding its solubility is vital for its practical application in various fields.

Key Factors Influencing Solubility:

  • Polarity: Due to the presence of the amide group, the compound exhibits some polar characteristics, enhancing solubility in polar solvents such as water and alcohols.
  • Hydrophobic Interactions: The piperidyl and pyridyl moieties add hydrophobic regions, which may limit solubility in purely aqueous environments.
  • Temperature: As with many compounds, solubility can be temperature-dependent; increasing temperature may enhance solubility in many solvents.

In summary, while N-[1-methyl-2-(1-piperidyl)ethyl]-N-(2-pyridyl)propanamide is likely soluble in a variety of solvents, careful consideration of solvent choice is necessary for effective use. It's often advised to conduct experiments to determine the solubility in specific solvents for accurate applications.

Interesting facts

Interesting Facts about N-[1-methyl-2-(1-piperidyl)ethyl]-N-(2-pyridyl)propanamide

N-[1-methyl-2-(1-piperidyl)ethyl]-N-(2-pyridyl)propanamide, known for its complex structure, belongs to a class of compounds that exhibit significant pharmacological activities. Here are some captivating insights about this intriguing compound:

  • Pharmacological Relevance: This compound is structurally related to various agents that target the central nervous system, particularly due to the presence of the piperidine and pyridine moieties. Such structures have been researched for their potential in antidepressant and analgesic medications.
  • Mechanism of Action: Beyond its structural elegance, the compound is believed to influence neurotransmitter systems, including serotonin and norepinephrine pathways, making it a subject of interest for developing new therapeutic agents.
  • Synthetic Pathways: The synthesis of this compound often involves multi-step chemical reactions. Chemists utilize methods such as amine alkylation and amide formation to create this complex structure.
  • Property Exploration: Researchers are constantly exploring the physicochemical properties of this compound to understand its behavior in different environments, which is essential for predicting its biological activity.
  • Drug Development: Understanding compounds like this one can lead to the discovery of novel drugs. Its unique combination of functional groups offers a scaffold for modifying the chemical structure to enhance efficacy and reduce adverse effects.

In summary, the exploration of N-[1-methyl-2-(1-piperidyl)ethyl]-N-(2-pyridyl)propanamide not only broadens our understanding of medicinal chemistry but also provides a promising pathway for new therapeutic innovations. Its involvement in neuropharmacology and the challenges of its synthesis illustrate the dynamic nature of chemical research.

Synonyms
PROPIRAM
Propiramum
15686-91-6
WT6247U6PX
Propionamide, N-(1-methyl-2-piperidinoethyl)-N-2-pyridyl-
BAY-4503 FREE BASE
DTXSID1023522
IDS-NP-016(SECT.2)
DTXCID703522
N-(1-methyl-2-piperidinoethyl)-N-(2-pyridyl)propionamide
239-775-7
Isopropiram
N-(1-Methyl-2-(1-piperidinyl)ethyl)-N-2-pyridinylpropanamide
52373-67-8
DEA No. 9649
Propanamide, N-(1-methyl-2-(1-piperidinyl)ethyl)-N-2-pyridinyl-
Propanamide, N-[1-methyl-2-(1-piperidinyl)ethyl]-N-2-pyridinyl-
Propiram [INN:BAN]
Propiramo
Propiramum [INN-Latin]
Propiramo [INN-Spanish]
EINECS 239-775-7
BRN 0485057
UNII-WT6247U6PX
(RS)-cis-N-(2-Piperidinopropyl)-N-2-pyridylpropionamide
PROPIRAM [INN]
PROPIRAM [MI]
Propionamide, N-(2-piperidinopropyl)-N-2-pyridyl-, (RS)-(Z)-
PROPIRAM [WHO-DD]
SCHEMBL26193
(+/-)-PROPIRAM
CHEMBL2110985
N-(1-methyl-2-piperidinoethyl)-N-2-pyridylpropionamide
CHEBI:135140
N-(1-piperidin-1-ylpropan-2-yl)-N-pyridin-2-ylpropanamide
Pregnane-11,20-dione, 3,21-dihydroxy-, (3-alpha,5-alpha)-
Propionamide, N-(1-methyl-2-(1-piperidinyl)ethyl)-N-2-pyridyl-
L004589
Q7250338
N-(1-Methyl-2-piperidinoethyl)-N-2-pyridinylpropionamide
N-(1-methyl-2-piperidin-1-ylethyl)-N-pyridin-2-ylpropanamide
(.+/-.)-N-(1-Methyl-2-piperidinoethyl)-N-2-pyridylpropionamide
Propionamide, N-(1-methyl-2-piperidinoethyl)-N-2-pyridyl-, (.+/-.)-