Skip to main content

Modafinil

ADVERTISEMENT
Identification
Molecular formula
C15H15NO2F3
CAS number
68693-11-8
IUPAC name
N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]-2-phenyl-acetamide
State
State

At room temperature, Modafinil is in a solid state.

Melting point (Celsius)
164.00
Melting point (Kelvin)
437.00
Boiling point (Celsius)
490.00
Boiling point (Kelvin)
763.00
General information
Molecular weight
273.35g/mol
Molar mass
273.3490g/mol
Density
1.3000g/cm3
Appearence

Modafinil generally appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]-2-phenyl-acetamide

The solubility of N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]-2-phenyl-acetamide can be a complex characteristic influenced by its molecular structure. This compound, with its sizable phenyl groups and the presence of the trifluoromethyl substituent, tends to exhibit the following traits:

  • Solvent Compatibility: Organic solvents such as methanol, ethanol, and acetone may solubilize this compound effectively due to its nonpolar to slightly polar nature.
  • Water Solubility: N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]-2-phenyl-acetamide is likely to have low solubility in water due to the hydrophobic characteristics of the phenyl and trifluoromethyl groups.
  • Temperature Dependency: Solubility may increase at elevated temperatures, making it essential to consider temperature effects when dissolving in organic solvents.

In summary, while N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]-2-phenyl-acetamide primarily favors solubility in organic solvents, it exhibits limited solubility in aqueous environments. This behavior underscores the significance of understanding chemical structure when evaluating solubility. As stated, “Like dissolves like,” highlighting the importance of polarity in solubility characteristics.

Interesting facts

Interesting Facts about N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]-2-phenyl-acetamide

N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]-2-phenyl-acetamide, often referred to in scientific circles for its interesting structure and properties, is a compound that showcases the fascinating world of organic synthesis and medicinal chemistry. Below are some engaging insights:

  • Pharmacological Potential: This compound belongs to a class of amides, which are known for their diverse biological activities. Researchers are particularly interested in its potential applications in treating various conditions due to its unique chemical structure.
  • Fluorinated Derivatives: The presence of a trifluoromethyl group in this molecule significantly influences its pharmacodynamics and lipophilicity. For comparison, fluorinated compounds often exhibit enhanced metabolic stability and can modulate biological interactions, making them crucial in drug design.
  • Synthetic Pathways: The synthesis of this compound often involves advanced organic chemistry techniques. The strategies can include a combination of Friedel-Crafts reactions and amide bond formation, demonstrating the intricate dance of atoms in creating complex structures.
  • Applications in Material Science: Beyond biological applications, fluorinated compounds like this one are also exploring roles in materials science. They can contribute to the development of new materials with unique thermal and chemical resistance properties.
  • Research Opportunities: Scientists are continually exploring the modification and optimization of similar compounds. The quest for understanding how slight variations in structure can lead to substantially different biological outcomes is a compelling avenue for research.

In summary, N-[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]-2-phenyl-acetamide not only represents an intriguing molecule from a structural standpoint but also embodies the vast potential within the field of chemistry. Its study offers insights into how structure influences function, paving the way for future innovations in drug development and materials science.

Synonyms
BRN 2885888
21015-09-8
N-(alpha-Methyl-m-trifluoromethylphenethyl)-2-phenylacetamide
ACETAMIDE, N-(alpha-METHYL-m-TRIFLUOROMETHYLPHENETHYL)-2-PHENYL-
RefChem:315491
DTXSID70943314
2-Phenyl-N-{1-[3-(trifluoromethyl)phenyl]propan-2-yl}ethanimidic acid