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Fentanyl

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Identification
Molecular formula
C22H28N2O
CAS number
437-38-7
IUPAC name
N-[(1-methyl-4-phenyl-4-piperidyl)methyl]-4-[4-[(1-methyl-4-phenyl-4-piperidyl)methylcarbamoyl]phenyl]benzamide
State
State

At room temperature, Fentanyl typically exists as a solid crystalline powder. Due to its powerful analgesic properties, it is often utilized in medical applications in different forms including transdermal patches, lozenges, and injectable solutions.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.70
Boiling point (Celsius)
574.60
Boiling point (Kelvin)
847.80
General information
Molecular weight
336.47g/mol
Molar mass
336.4670g/mol
Density
1.1873g/cm3
Appearence

Fentanyl is typically available as a white to off-white crystalline powder in its pure form. However, in its pharmaceutical form, it can be found in various formulations including patches, lozenges, and injectables, tailored to specific medical applications. Due to its potent nature, it is often handled and distributed with extreme care.

Comment on solubility

Solubility of N-[(1-methyl-4-phenyl-4-piperidyl)methyl]-4-[4-[(1-methyl-4-phenyl-4-piperidyl)methylcarbamoyl]phenyl]benzamide

The solubility of the compound N-[(1-methyl-4-phenyl-4-piperidyl)methyl]-4-[4-[(1-methyl-4-phenyl-4-piperidyl)methylcarbamoyl]phenyl]benzamide is influenced by several factors:

  • Polarity: This compound exhibits varying degrees of polarity due to its intricate structure, which may affect its solubility in different solvents.
  • Functional Groups: The presence of both amide and carbamoyl functional groups can enhance solubility in polar organic solvents. These groups may form hydrogen bonds with solvent molecules.
  • Hydrophobic Regions: The bulky phenyl rings in the molecular structure introduce hydrophobic characteristics, which can limit solubility in water.
  • Solvent Interaction: Depending on the solvent used (e.g., water, ethanol, DMSO), solubility can vary significantly. For instance, strong hydrogen-bonding solvents may improve solubility.

In summary, the overall solubility of this compound is a complex interplay between its different functional groups and the surrounding solvent. As a quote often states, "Solubility is not merely a measure of quantity, but of interaction." To fully understand its behaviors in various environments, further experimental data would be necessary.

Interesting facts

Interesting Facts about N-[(1-methyl-4-phenyl-4-piperidyl)methyl]-4-[4-[(1-methyl-4-phenyl-4-piperidyl)methylcarbamoyl]phenyl]benzamide

This compound stands out in the realm of medicinal chemistry due to its complex structure and potential therapeutic applications. Often synthesizing compounds within this class is driven by the pursuit of enhancing pharmacological effects, particularly as they relate to neurological disorders.

Key Features:

  • Substituted Piperidine Ring: The inclusion of a piperidine moiety contributes to the compound's ability to interact effectively with various biological targets, particularly receptors associated with neurotransmission.
  • Phenyl Groups: The presence of phenyl groups in the structure not only aids in enhancing the lipophilicity of the compound but can also play a role in modulating biological activity.
  • Cyclic Amine: The cyclic nature of the piperidine ring presents opportunities for interesting conformational dynamics, which may influence how the compound interacts with proteins.

Throughout research, compounds such as this one have been under exploration for:

  1. Treatment of neurodegenerative diseases, acting on receptors involved in cognitive function.
  2. Potential roles in pain management, especially those conditions tied to neuropathic origins.
  3. Investigation as antidepressant agents, considering the structural analogies to known psychoactive compounds.

The field of pharmacology continuously evolves, uncovering newer methods of utilizing such compounds. As scientists dissect the intricate details of N-[(1-methyl-4-phenyl-4-piperidyl)methyl]-4-[4-[(1-methyl-4-phenyl-4-piperidyl)methylcarbamoyl]phenyl]benzamide, they hope to unlock mechanisms that could lead to breakthroughs in patient treatment methodologies. As with any complex chemical, the interplay of its structural elements and their contributions to biological activity remains an intriguing area for ongoing research.

Synonyms
15234-97-6
BRN 0469489
4,4'-BIPHENYLDICARBOXAMIDE, N,N'-BIS(1-METHYL-4-PHENYL-4-PIPERIDYLMETHYL)-
DTXSID80165005
N,N'-(1-Methyl-4-phenyl-4-piperidylmethyl)-4,4'-diphenyl bis-carboxamide
N,N'-Bis(1-methyl-4-phenyl-4-piperidylmethyl)-4,4'-biphenyldicarboxamide
DTXCID0087496
5-22-09-00506 (Beilstein Handbook Reference)
N-[(1-methyl-4-phenylpiperidin-4-yl)methyl]-4-[4-[(1-methyl-4-phenylpiperidin-4-yl)methylcarbamoyl]phenyl]benzamide
4,4/'-Biphenyldicarboxamide, N,N/'-bis(1-methyl-4-phenyl-4-piperidylmethyl)-