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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
State
State

At room temperature, colchicine is in a solid state, typically as a crystalline powder.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
689.10
Boiling point (Kelvin)
962.25
General information
Molecular weight
399.44g/mol
Molar mass
399.4390g/mol
Density
1.5500g/cm3
Appearence

Colchicine appears as a white to yellowish crystalline solid. It is typically found in a powdered form but can also form needle-like crystals. It can dissolve in alcohol and chloroform but is less soluble in water.

Comment on solubility

Solubility of N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide

The solubility of N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide can be a complex topic due to several structural and environmental factors. Here are some key points to consider:

  • Solvent Polarity: The solubility of this compound is likely to be significantly influenced by the polarity of the solvent. Polar solvents, such as water, may not effectively dissolve non-polar compounds, while apolar solvents might be more suitable.
  • Functional Groups: The presence of multiple methoxy (–OCH3) groups indicates potential interactions with polar solvents, which may enhance its solubility compared to non-polar environments.
  • Thermodynamic Factors: Temperature and pressure can also play a crucial role in solubility. Typically, increasing temperature may increase the solubility of solid compounds in solvents.
  • Structural Considerations: The bulkiness and stereochemistry of the benzo[a]heptalene structure may influence how well the compound can interact with solvent molecules, impacting its overall solubility.

In conclusion, understanding solubility is essential for predicting the behavior of N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide in various environments. As with many compounds, experimentation and detailed analysis can provide valuable insights into its solubility profile.

Interesting facts

Interesting Facts about N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide

N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide, a fascinating compound in the field of organic chemistry, presents a rich tapestry of characteristics that intrigue scientists and researchers alike.

1. Structural Complexity

  • This compound features a multi-faceted structure that includes a benzo[a]heptalene core, a structure known for its aromaticity and potential biological activity.
  • It contains multiple functional groups, such as hydroxyl and methoxy groups, which contribute to its chemical reactivity and interaction with biological systems.

2. Potential Biological Activities

Research suggests that compounds with similar structural motifs may exhibit a range of biological activities, including:

  • Antioxidant properties: Compounds with hydroxyl groups are often known for their ability to neutralize free radicals.
  • Anti-inflammatory effects: The presence of specific functional groups may help modulate inflammatory processes in the body.
  • Antimicrobial activity: Some derivatives of similar structures have been shown to possess inhibition against various microorganisms.

3. Synthetic Challenges

The synthesis of such complex molecules can be demanding, often requiring:

  • Advanced techniques in organic synthesis.
  • Multiple reaction steps to achieve the desired functionalization.
  • Careful planning and execution to ensure that all functional groups are correctly placed and preserved during the synthesis.

4. Applications in Medicinal Chemistry

Given its structural attributes, this compound may pave the way for:

  • Development of new pharmaceuticals targeting specific disease pathways.
  • Creation of novel materials with unique properties.

5. Intriguing Research Opportunities

As a point of interest for future research, the compound could be explored further for:

  • Its role as a lead compound in drug discovery.
  • Investigating structure-activity relationships to optimize its pharmacological profile.

In summary, N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide stands as a testament to the wonders of synthetic organic chemistry and its potential implications in various scientific fields. As research continues, this compound may yield new insights and advancements that address pressing health concerns and material needs.

Synonyms
N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
MLS001202244
N-(10-Hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
SMR000564997
MFCD00598980
cid_10156
SCHEMBL177859
CHEMBL323668
BDBM66784
HMS1648C14
HMS3340L13
N-[(7S,12aRa)-10-Hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide (Colchiceine)
STR08954
SYB69572
NSC371715
STL373174
AKOS001580935
AKOS017342895
DB15534
NSC-371715
NCGC00095943-01
AB00830015-06
EN300-22939293
N-(10-hydroxy-9-keto-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
N-(1,2,3-trimethoxy-10-oxidanyl-9-oxidanylidene-6,7-dihydro-5H-benzo[a]heptalen-7-yl)ethanamide
N-{14-hydroxy-3,4,5-trimethoxy-13-oxotricyclo[9.5.0.0(2),?]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl}acetamide
N-{14-hydroxy-3,4,5-trimethoxy-13-oxotricyclo[9.5.0.0,2,7]hexadeca-1(16),2,4,6,11,14-hexaen-10-yl}acetamide