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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
N-(1,1-dimethylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide
State
State

Colchicine is typically found as a solid at room temperature, usually in crystalline form.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
490.00
Boiling point (Kelvin)
763.15
General information
Molecular weight
399.44g/mol
Molar mass
399.4420g/mol
Density
1.3300g/cm3
Appearence

Colchicine appears as a pale yellow, crystalline powder, often with a glossy sheen. It has a distinct crystalline structure that is typical of many crystalline solid organic compounds.

Comment on solubility

Solubility of N-(1,1-dimethylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide

The solubility of N-(1,1-dimethylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide can be influenced by several factors:

  • Polarity: This compound has a complex structure that typically results in low to moderate polarity, affecting its solubility in different solvents.
  • Solvent Types: It is expected to be more soluble in non-polar solvents (such as hexane) than in polar solvents (like water) due to the hydrophobic characteristics introduced by the dimethyl and phenyl groups.
  • Functional Groups: The presence of multiple methoxy groups can enhance its solubility in organic solvents, contributing to its overall solvability in specific conditions.
  • Temperature Effects: Solubility often increases with temperature; thus, warming the solvent may improve the dissolution of this compound.

In general, for compounds of this nature, a systematic solubility assessment is recommended, as the unique structural details play a crucial role in determining how well it can dissolve in various environments.

Interesting facts

Interesting Facts about N-(1,1-dimethylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide

N-(1,1-dimethylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide is a fascinating compound that stands out in the field of organic chemistry due to its complex structure and potential applications. Here are some intriguing aspects worth noting:

  • Diverse Applications: This compound is not only important in synthetic organic chemistry but is also explored for its potential pharmaceutical properties, particularly in relation to its anti-inflammatory and analgesic activities.
  • Structural Complexity: The presence of both the dimethylprop-2-ynyl group and the trimethoxyphenyl moiety gives this compound a unique and versatile structure that can lead to interesting reactivity patterns.
  • Functional Groups: It contains multiple functional groups, including an amide linkage and a conjugated system, which can influence its reactivity and interaction with biological systems.
  • Reactivity Insights: The alkyne functionality in the compound might provide opportunities for further chemical modifications, making it a valuable starting point for synthesizing related compounds.
  • Research Potential: Due to its complex framework, ongoing research is likely to reveal even more about its biological properties, paving the way for new drug discoveries.
  • Mechanism Studies: The understanding of how compounds like this interact on a molecular level, particularly through mechanisms such as enzyme inhibition or receptor binding, makes it a rewarding subject of study in medicinal chemistry.

In summary, N-(1,1-dimethylprop-2-ynyl)-3-(3,4,5-trimethoxyphenyl)prop-2-enamide represents an exciting intersection of organic synthesis and pharmacology. The continuing explorations into its properties and potential therapeutic applications underline the ever-evolving landscape of chemical research.

Synonyms
orb1701395