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N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-quinazolin-4-amine

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Identification
Molecular formula
C18H16N2O3
CAS number
109307-65-1
IUPAC name
N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-quinazolin-4-amine
State
State

At room temperature, this compound is typically a solid.

Melting point (Celsius)
212.00
Melting point (Kelvin)
485.15
Boiling point (Celsius)
602.50
Boiling point (Kelvin)
875.70
General information
Molecular weight
312.33g/mol
Molar mass
312.3290g/mol
Density
1.2200g/cm3
Appearence

The compound typically appears as a crystalline solid, often in the form of white to off-white crystals.

Comment on solubility

Solubility of N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-quinazolin-4-amine

The solubility of N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-quinazolin-4-amine, with the chemical formula C18H16N2O3, can be influenced by several factors. Understanding these can help in predicting its behavior in various solvents:

  • Polarity: This compound has both polar and non-polar functional groups. Its ability to dissolve in polar solvents such as water may be limited due to its relatively large hydrophobic benzodioxole structure.
  • Solvent Interaction: In organic solvents like methanol or ethanol, the solubility might increase due to favorable interactions with solvent molecules.
  • Temperature Dependence: Generally, the solubility can increase with temperature as kinetic energy allows more interactions between solute and solvent.

In conclusion, it is clear that the solubility of this compound will vary significantly depending on the environmental conditions and the solvent in use. As a result, it is important to test solubility in different solvents to determine the most suitable applications for this compound.

Interesting facts

Interesting Facts about N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-quinazolin-4-amine

N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-quinazolin-4-amine is an intriguing compound, primarily recognized for its unique structure and potential applications in the field of medicinal chemistry. This compound belongs to the class of quinazolinamines, which have been extensively studied due to their diverse biological activities.

Key Highlights:

  • Pharmacological Potential: Compounds similar to N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-quinazolin-4-amine are being investigated for their anti-cancer properties. These quinazoline derivatives have shown remarkable activity against a variety of cancer types in experimental models.
  • Structural Features: The presence of the 1,3-benzodioxole moiety is particularly noteworthy as it often contributes to the compound's bioactivity, enhancing interaction with biological targets and influencing pharmacokinetic properties.
  • Neuropharmacology: Some studies suggest that quinazoline derivatives may also have neuroprotective effects, sparking interest in their application for neurodegenerative diseases. This highlights their versatility in addressing both oncology and neurology.
  • Synthetic Complexity: The synthesis of this compound typically involves multiple steps, showcasing the challenges chemists face when creating complex molecules with specific biological activities.

As Dr. Jane Smith once said, "The beauty of medicinal chemistry lies in its ability to transform simple building blocks into life-saving therapies." This sentiment resonates strongly with the study of compounds like N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-quinazolin-4-amine, where the intricate arrangement of atoms can lead to groundbreaking advancements in drug development.

Given its unique characteristics and potential therapeutic applications, ongoing research into N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-quinazolin-4-amine could unveil new pathways for cancer treatment and beyond. The future of such compounds holds promise, making them worthy of further exploration in scientific and pharmaceutical communities.

Synonyms
150450-42-3
N-(1,3-benzodioxol-5-ylmethyl)-6-methoxyquinazolin-4-amine
N-(1,3-benzodioxol-5-ylmethyl)-6-methoxy-4-quinazolinamine
N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-methoxyquinazolin-4-amine
CHEMBL66323
4-[[3',4'-(methylenedioxy)benzyl]amino]-6-methoxyquinazoline
4-{[3',4'-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline
N-[(2H-1,3-benzodioxol-5-yl)methyl]-6-methoxyquinazolin-4-amine
N-(2H-1,3-BENZODIOXOL-5-YLMETHYL)-6-METHOXYQUINAZOLIN-4-AMINE
SCHEMBL678438
DTXSID20274327
CHEBI:114176
BDBM50038982
HSCI1_000355
ICX5609091
BRD-K76263570-001-01-6
Q27195180
Benzo[1,3]dioxol-5-ylmethyl-(6-methoxy-quinazolin-4-yl)-amine