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Diflunisal

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Identification
Molecular formula
C13H8Cl2N2O2
CAS number
22494-42-4
IUPAC name
N-(1,7-dichloro-9-oxo-fluoren-4-yl)acetamide
State
State

At room temperature, Diflunisal is in a solid state, typically found as a crystalline powder.

Melting point (Celsius)
211.00
Melting point (Kelvin)
484.15
Boiling point (Celsius)
375.00
Boiling point (Kelvin)
648.15
General information
Molecular weight
297.15g/mol
Molar mass
297.1490g/mol
Density
1.4560g/cm3
Appearence

N-(1,7-dichloro-9-oxo-fluoren-4-yl)acetamide, commonly known as Diflunisal, appears as a white crystalline powder. It is known for its application as a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

Comment on solubility

Solubility of N-(1,7-dichloro-9-oxo-fluoren-4-yl)acetamide

The solubility of N-(1,7-dichloro-9-oxo-fluoren-4-yl)acetamide can be influenced by several factors including its molecular structure and the presence of functional groups. Generally, compounds like this one may exhibit the following solubility characteristics:

  • Polarity: The presence of polar acetamide groups may increase solubility in polar solvents.
  • Hydrophobic Regions: The fluorenyl structure contributes a considerable hydrophobicity, potentially decreasing solubility in water.
  • Solvent Compatibility: This compound is likely to dissolve better in organic solvents such as ethanol or dichloromethane than in water.
  • Temperature Effects: Increased temperature typically enhances solubility for many organic compounds, which could apply here as well.

As a general statement, one could claim that “solubility is a dance between molecular attractions and interactions with the solvent.” Thus, predicting the exact solubility requires not only theoretical knowledge but practical experimentation as well. Understanding these behavioral patterns could facilitate the effective use of N-(1,7-dichloro-9-oxo-fluoren-4-yl)acetamide in various applications.

Interesting facts

Interesting Facts about N-(1,7-dichloro-9-oxo-fluoren-4-yl)acetamide

N-(1,7-dichloro-9-oxo-fluoren-4-yl)acetamide is a fascinating compound that has garnered attention in the fields of organic chemistry and pharmaceuticals. Here are some intriguing aspects of this compound:

  • Structure and Functionality: This compound features a unique structure characterized by its fluorene backbone, which is known for its stability and ability to form strong π-π interactions. These structural attributes make it highly interesting for research on materials and drugs.
  • Potential Applications: Due to its chemical properties, N-(1,7-dichloro-9-oxo-fluoren-4-yl)acetamide can serve as a precursor in the synthesis of various biologically active compounds. Its derivatives are investigated for anti-cancer properties and other therapeutic potentials.
  • Halogenated Features: The presence of chlorine atoms in its structure can influence its reactivity and biological activity. Chlorinated compounds are known for enhanced lipophilicity, which may affect their transport and absorption in biological systems.
  • Research Interest: The compound's significance is highlighted in scientific literature as researchers explore its interactions at the molecular level, aiming to understand its mechanism of action and improve its efficacy in various applications.
  • Safety Considerations: Despite its potential benefits, handling this compound requires caution due to the presence of chlorine. Proper safety protocols must be observed to minimize health risks in laboratory settings.

In summary, N-(1,7-dichloro-9-oxo-fluoren-4-yl)acetamide is not just another chemical entity; it represents a bridge between fundamental chemistry and applied sciences. Its unique properties and potential for impactful applications make it a compound of notable interest in both academic and industrial research.

Synonyms
NSC 74990
ACETAMIDE, N-(2,7-DICHLORO-9-OXOFLUOREN-4-YL)-
BRN 2750434
N-(2,7-Dichloro-9-oxofluoren-4-yl)acetamide
1785-05-3
N-(1,7-dichloro-9-oxofluoren-4-yl)acetamide
4-Acetylamino-2,7-dichloro-9H-fluoren-9-one