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Acemetacin

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Identification
Molecular formula
C26H33NO6
CAS number
53164-05-9
IUPAC name
N-[2-[[2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]methyl]-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
State
State

At room temperature, acemetacin is typically in a solid state.

Melting point (Celsius)
151.50
Melting point (Kelvin)
424.70
Boiling point (Celsius)
305.50
Boiling point (Kelvin)
578.70
General information
Molecular weight
545.63g/mol
Molar mass
545.6350g/mol
Density
1.3100g/cm3
Appearence

Acemetacin typically appears as a white to off-white crystalline powder or solid.

Comment on solubility

Solubility of N-[2-[[2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]methyl]-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide

The solubility of this complex organic compound is influenced by several key factors:

  • Functional Groups: The presence of multiple hydroxyl (-OH) groups suggests that the compound may have a considerable ability to form hydrogen bonds with water, enhancing its solubility in polar solvents.
  • Molecular Structure: The bulky cyclopentanophenanthrene moiety contributes to the compound's hydrophobic characteristics, potentially limiting its solubility in non-polar organic solvents.
  • pH Sensitivity: Depending on the pH of the solution, ionization may occur, affecting solubility. For instance, under acidic or basic conditions, the amide bond may influence solubilization behavior.
  • Concentration: As with many solutes, solubility can vary significantly with concentration. A higher concentration may lead to saturation and precipitate formation.

In summary, while the compound has favorable attributes for solubility in certain environments due to its polar character, its overall solubility profile would ultimately require empirical testing in various solvents to elucidate its full potential. Therefore, further studies exploring solubility in specific conditions and mediums are essential for a comprehensive understanding.

Interesting facts

Interesting Facts about N-[2-[[2-[(17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]methyl]-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide

This complex chemical compound represents a significant area of study due to its intricate structure and potential applications in various fields. Here are some interesting points to consider:

  • Structure Complexity: The compound features a multi-ring system, combining elements of both steroid-like structures and modified carbohydrate frameworks, reflecting the significant diversity in organic chemistry.
  • Biological Relevance: Given its steroidal backbone, this compound could be explored for hormonal activity, which is crucial in understanding endocrine functions and developing pharmaceutical treatments.
  • Synthetic Pathways: The synthesis of this compound likely involves multiple reaction steps, showcasing the challenges and creativity involved in obtaining complex organic molecules. Students and chemists might find the reaction mechanisms particularly fascinating.
  • Potential Applications: With its unique structure, this compound could have implications in drug development, especially in designing therapeutic agents that target specific biological pathways.
  • Research Opportunities: The intricate design of this compound opens up avenues for further research into its pharmacokinetics and pharmacodynamics, providing rich material for scientific investigation.

As noted by prominent chemists, "Understanding the structure-activity relationship is key in the development of new compounds with desired biological effects." This compound exemplifies such relationships, inviting chemical scientists and students alike to delve deeper into its potential.

Considering its structural details and potential applications, continued research into this compound may lead to breakthroughs in both chemistry and medicine, making it a noteworthy subject among chemical compounds.