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Insulin Glargine

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Identification
Molecular formula
C387H540N96O114S14
CAS number
160337-95-1
IUPAC name
N-[2-[[2-[[2-[[2-[[1-[[1-[[1-[2-(ethylcarbamoyl)pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide
State
State

Insulin Glargine is typically prepared as a liquid solution for injection. At room temperature, within its formulated solution, it remains a liquid.

Melting point (Celsius)
120.00
Melting point (Kelvin)
393.00
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.00
General information
Molecular weight
6063.00g/mol
Molar mass
6 063.0000g/mol
Density
1.1695g/cm3
Appearence

Insulin Glargine is a clear, colorless, and sterile aqueous solution. It lacks particulate matter, ensuring it is free from any visible impurities or contaminants.

Comment on solubility

Solubility of N-[2-[[2-[[2-[[2-[[1-[[1-[[1-[2-(ethylcarbamoyl)pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide

The solubility of the complex compound N-[2-[[2-[[2-[[2-[[1-[[1-[[1-[2-(ethylcarbamoyl)pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide is markedly influenced by several factors:

  • Polarity: Given its extensive peptide and functional group structure, this compound likely displays both polar and non-polar characteristics, which can affect solubility in different solvents.
  • Hydrogen Bonding: The presence of multiple amide and hydroxyl groups enables strong hydrogen bonding, enhancing solubility in polar solvents such as water.
  • Size and Molecular Weight: With a high molecular weight (C387H540N96O114S14), the solubility may be limited due to steric hindrance despite the favorable interactions of functional groups.
  • pH Sensitivity: Changes in pH could affect the protonation of various functional groups, possibly enhancing or reducing solubility based on the ionic form of the compound.

In summary, while the compound might exhibit some solubility in water and organic solvents due to its polar groups, the overall solubility can be quite limited by its large and complex structure. As a result, empirical testing is recommended to precisely determine solubility in various conditions, since it could lead to variable solubility behavior.

Interesting facts

Interesting Facts about N-[2-[[2-[[2-[[2-[[1-[[1-[[1-[2-(ethylcarbamoyl)pyrrolidine-1-carbonyl]-4-guanidino-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]amino]-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide

This incredibly complex compound boasts a wide array of fascinating features that make it stand out in the realm of chemistry. Here are some key points:

  • Structural Complexity: The compound consists of a staggering number of atoms, with a diverse assembly of functional groups, including guanidino, carbamoyl, and pyrrolidine moieties, which contribute to its overall functionality.
  • Potential Applications: Given its intricate structure, this compound has promising applications in fields such as medicinal chemistry. Compounds with similar architectures are often researched for their potential as therapeutic agents.
  • Research Interest: The multidimensional characteristics of this compound may lead to studies focusing on its bioactivity, stability, and interaction with biological targets, making it a subject of intense investigation.
  • Modular Design: The structure highlights a modular design approach in medicinal chemistry, where different functional groups can be combined to achieve desired therapeutic effects or enhance properties.
  • Interdisciplinary Fields: The study of such compounds often requires knowledge from various fields including organic chemistry, biochemistry, and pharmacology, showcasing the collaborative nature of scientific research.

The sheer scale of this compound presents both challenges and opportunities for chemists. The intricate relationships between its components could prove invaluable for developing new drugs or understanding biological pathways. As emphasized in the academic community, "The complexity of structure often correlates with the richness of function." This statement rings particularly true when examining compounds like this one, which hold the potential for advancing our understanding of chemical interactions.

Synonyms
Leuprelin Acetate
Leuprorelina
(D-SER4)-LEUPROLIDE
Leuprorelin (INN)
Enantone (TN)
SCHEMBL3036508
SCHEMBL10061885
SCHEMBL22555626
NSC377526
NS00003681
C07612
D08113
L001094
L002030