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Hydrochlorothiazide

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Identification
Molecular formula
C7H8ClN3O4S2
CAS number
58-93-5
IUPAC name
N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-sulfamoyl-benzamide
State
State
Solid at room temperature. It is often used in crystalline form.
Melting point (Celsius)
273.00
Melting point (Kelvin)
546.15
Boiling point (Celsius)
531.00
Boiling point (Kelvin)
804.15
General information
Molecular weight
297.74g/mol
Molar mass
297.7400g/mol
Density
1.6708g/cm3
Appearence

White, or practically white, crystalline powder

Comment on solubility

Solubility of N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-sulfamoyl-benzamide

N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-sulfamoyl-benzamide, with the chemical formula C7H8ClN3O4S2, exhibits notable solubility characteristics that are important for its application in various fields. In assessing the solubility of this compound, several key factors come into play:

  • Polarity: The presence of amine and sulfonamide functional groups contributes to the compound's overall polarity, enhancing its ability to dissolve in polar solvents like water.
  • Hydrogen Bonding: The structure allows for extensive hydrogen bonding with water molecules, which often facilitates greater solubility in aqueous environments.
  • Electrostatic Interactions: The inclusion of a sulfonyl moiety may invoke additional electrostatic interactions that further aid in solvation.

When considering its solubility, particularly in water, it is essential to note that:

  • The compound is expected to be moderately soluble in water due to its polar nature.
  • Solubility might vary depending on the pH of the solution, as the ionization of the sulfonamide could affect the compound's solubility profile.
  • Organic solvents could also impact the solubility, with some solvents enhancing the dissolution due to compatibility with hydrophobic segments of the molecule.

In conclusion, the solubility behavior of N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-sulfamoyl-benzamide is governed by a combination of structural features, leading to its practical utility in various applications. Understanding the solubility will aid in optimizing its use in pharmaceutical formulations and other chemical processes.

Interesting facts

Interesting Facts About N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-sulfamoyl-benzamide

N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-sulfamoyl-benzamide is a captivating compound that showcases the intricate interplay of organic chemistry and medicinal applications. Here are some noteworthy aspects of this compound:

  • Pharmaceutical Relevance: This compound belongs to the class of sulfonamide drugs, which are known for their capacity to inhibit bacterial growth by interfering with folic acid synthesis. They have been a cornerstone in antibacterial treatments for decades.
  • Molecular Design: The structural complexity of this molecule is fascinating. It features a sulfonamide functional group bonded to a benzamide structure, combined with an ether-like side chain that enhances its solubility characteristics, making it suitable for various biological environments.
  • Amino Group Importance: The presence of the aminoethoxy moiety not only adds functional versatility but can also play a significant role in receptor interactions within biological systems. This could potentially lead to novel therapeutic applications beyond typical antibacterial functions.
  • Research Potential: Ongoing studies focus on modifying the structure of sulfonamides like this compound to improve efficacy and reduce side effects. By tweaking functional groups, researchers aim to discover new derivatives with enhanced biological activities.
  • Safety and Efficacy: Initial studies have shown that compounds in this class are generally well-tolerated, yet understanding their pharmacokinetics and pharmacodynamics is essential for assessing long-term use and safety profiles in patients.

In conclusion, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-sulfamoyl-benzamide is more than a mere chemical formula; it is a testament to the creative potential of chemists aiming to devise solutions to some of the most pressing health challenges of our time. As *Walt Whitman* once said, "We contain multitudes," and similarly, this compound embodies a multitude of possibilities in the realm of medicinal chemistry.

Synonyms
165618-72-4
aminodi(ethyloxy)ethylaminocarbonylbenzenesulfonamide
N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-sulfamoylbenzamide
P7AMK4J5SW
EG2
DTXSID10274356
N-{2-[2-(2-aminoethoxy)ethoxy]ethyl}-4-sulfamoylbenzamide
N-(2-[2-(2-Amino-ethoxy)-ethoxy]-ethyl)-4-sulfamoyl-benzamide
N-(2-(2-(2-Aminoethoxy)ethoxy)ethyl)-4-sulfamoylbenzamide
N-{2-[2-(2-Amino-ethoxy)-ethoxy]-ethyl}-4-sulfamoyl-benzamide
N-[2-[2-(2-AMINO-ETHOXY)-ETHOXY]-ETHYL]-4-SULFAMOYL-BENZAMIDE
1cnx
EG-2
DTXCID40225836
Benzamide, N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-4-(aminosulfonyl)-
DB02535
PD007887
NS00068891
H28469
A1-08907
Q27093515
Z2787462845
N-{2-[2-(2-Aminoethoxy)-ethoxy]-ethyl}-4-sulfamoylbenzamide
N-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-4-(aminosulfonyl)benzamide