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Etodolac

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Identification
Molecular formula
C17H21NO3
CAS number
41340-25-4
IUPAC name
N-[2-(2-acetamidophenyl)ethyl]-1-hydroxy-naphthalene-2-carboxamide
State
State

Etodolac is in solid state at room temperature.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
833.30
Boiling point (Kelvin)
1 106.45
General information
Molecular weight
287.34g/mol
Molar mass
287.3360g/mol
Density
1.2373g/cm3
Appearence

Etodolac is generally found as a white to off-white crystalline powder.

Comment on solubility

Solubility of N-[2-(2-acetamidophenyl)ethyl]-1-hydroxy-naphthalene-2-carboxamide

N-[2-(2-acetamidophenyl)ethyl]-1-hydroxy-naphthalene-2-carboxamide, with its complex structure, presents interesting characteristics in terms of solubility. The solubility of this compound can be influenced by several factors:

  • Polarity: Due to the presence of an amide group, the compound exhibits polar characteristics, which may enhance its solubility in polar solvents.
  • Hydrogen Bonding: The hydroxyl and amide functional groups can engage in hydrogen bonding, potentially increasing solubility in water or alcohols.
  • Temperature: Like many organic compounds, solubility can be temperature-dependent. An increase in temperature often enhances the solubility of solid compounds in liquid solvents.
  • pH Levels: The ionic state of the compound can change with varying pH levels, thereby affecting solubility. The presence of acidic or basic conditions may aid in the dissolution process.

It is essential to note that while some related compounds exhibit high solubility in organic solvents, the exact solubility profile of N-[2-(2-acetamidophenyl)ethyl]-1-hydroxy-naphthalene-2-carboxamide may vary and should be experimentally determined.

In conclusion, understanding the solubility of this compound can greatly aid in predicting its behavior in various chemical environments and in applications such as drug delivery or organic synthesis.

Interesting facts

Exploring N-[2-(2-acetamidophenyl)ethyl]-1-hydroxy-naphthalene-2-carboxamide

N-[2-(2-acetamidophenyl)ethyl]-1-hydroxy-naphthalene-2-carboxamide, often referred to in the scientific community for its intricate structure and potential applications, is a compound of significant interest. Here are some engaging facts about this compound:

  • Multi-functional properties: This compound features a unique combination of a naphthalene core and an acetylated amine side chain, positioning it as a candidate for diverse applications in pharmaceuticals and material science.
  • Biological relevance: Compounds with similar structures have been studied for their potential as therapeutic agents, particularly in the areas of anti-cancer and anti-inflammatory treatments. Researchers are intrigued by the possible mechanisms through which this compound can exert its effects.
  • Structure-activity relationship (SAR): Understanding how the modifications in its structure influence biological activity is central to medicinal chemistry. The presence of both the hydroxyl and carboxamide functional groups can offer multiple sites for interaction with biological targets.
  • Research implications: Ongoing studies are examining the synthesis pathways and reactivity profiles of this compound, which could pave the way for new derivatives with enhanced efficacy and safety.
  • Potential in material science: Besides biological applications, the unique structure of this compound may lead to interesting properties in polymers and nanomaterials, showcasing the interdisciplinary nature of modern chemical research.

As quoted by renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." The study of compounds like N-[2-(2-acetamidophenyl)ethyl]-1-hydroxy-naphthalene-2-carboxamide embodies this philosophy, allowing scientists to explore a myriad of possibilities in both chemistry and biology.

This compound stands as a reminder of the endless potential of chemical compounds, continually inviting scientists and chemists to delve deeper into its multifaceted characteristics.

Synonyms
2-Naphthalenecarboxamide, N-[2-[2-(acetylamino)phenyl]ethyl]-1-hydroxy-
EINECS 226-055-2
BRN 2899318
1-Hydroxy-2-(beta-(2'-acetamidophenyl)-ethyl)-naphthamide
DTXSID9063742
2-Naphthalenecarboxamide, N-(2-(2-(acetylamino)phenyl)ethyl)-1-hydroxy-
2-NAPHTHALENECARBOXAMIDE, N-(o-(ACETYLAMINO)PHENETHYL)-1-HYDROXY-
DTXCID7041207
5254-41-1
N-(2-ACETAMIDOPHENETHYL)-1-HYDROXY-2-NAPHTHAMIDE
N-[2-(2-acetamidophenyl)ethyl]-1-hydroxynaphthalene-2-carboxamide
MFCD00051399
SCHEMBL590189
N-[2-(2-Acetamidophenyl)ethyl]-1-hydroxy-2-naphthamide
HNLJTZUJURZMTN-UHFFFAOYSA-N
N-{2-[2-(Acetylamino)phenyl]ethyl}-1-hydroxy-2-naphthamide
N-(2-(2-(Acetylamino)phenyl)ethyl)-1-hydroxynaphthalene-2-carboxamide
AKOS003602450
SB83282
DB-052137
NS00032523
N-(2-Acetamido-phenethyl)-1-hydroxy-2-naphthamide