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Carmustine

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Identification
Molecular formula
C9H13N3O5
CAS number
154-93-8
IUPAC name
N-[2-(2-carbamoylpyrrolidin-1-yl)-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide
State
State

The compound is generally in a solid state at room temperature and appears as an amber crystalline powder. It must be handled with care due to its sensitivity to environmental conditions.

Melting point (Celsius)
30.00
Melting point (Kelvin)
303.15
Boiling point (Celsius)
337.30
Boiling point (Kelvin)
610.45
General information
Molecular weight
357.39g/mol
Molar mass
357.3880g/mol
Density
1.7855g/cm3
Appearence

Carmustine typically appears as a light amber solid or powder. It is sensitive to light and moisture, prone to hydrolysis and decomposition, which can alter its appearance over time.

Comment on solubility

Solubility of N-[2-(2-carbamoylpyrrolidin-1-yl)-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide

N-[2-(2-carbamoylpyrrolidin-1-yl)-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide is a complex compound, and its solubility can be influenced by multiple factors, making it intriguing to study. Here are some key points regarding its solubility:

  • Polarity: The solubility of this compound is likely to be affected by its polar and non-polar characteristics, stemming from the presence of various functional groups, such as amides and carbonyls.
  • Solvent Type: It is expected to have variable solubility in organic solvents and polar protic solvents, although specific solubility data may need to be referenced for clarity.
  • pH Dependency: The solubility may also be pH-dependent, particularly due to the ionizable nature of amide groups under different pH conditions.
  • Hydration and Crystal Lattice: The crystal structure plays a significant role; hence, the hydration and crystalline form could greatly affect how well this compound dissolves in water.

Overall, while we can infer that the compound may exhibit some solubility characteristics, definitive laboratory testing would provide precise information. As always, consulting specific solubility studies or databases can yield valuable insight into the solubility profiles of such complex compounds.

Interesting facts

Interesting Facts about N-[2-(2-Carbamoylpyrrolidin-1-yl)-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide

This fascinating compound is a member of a class known for its potential pharmacological applications. Here are some key points to consider:

  • Structure and Complexity: The compound features a unique combination of pyrrolidine and imidazole rings, contributing to its fascinating properties. Its intricate structure is indicative of the evolving landscape of medicinal chemistry.
  • Biological Relevance: Compounds like this one are often investigated for their potential roles in treating conditions such as neurological disorders and cancer. The presence of multiple functional groups can lead to diverse interactions with biological targets.
  • Research Applications: This compound serves as a valuable tool in research, often used to develop novel therapies or as a reference in studies focusing on enzyme inhibition or receptor binding.
  • Synergy in Therapeutics: When combined with other agents, compounds like this one may exhibit synergistic effects, enhancing their therapeutic efficacy and minimizing side effects.
  • Future Perspectives: As research continues in the realm of drug discovery, this compound could pave the way for new therapeutic approaches, making it a significant subject of study in organic and medicinal chemistry.

In conclusion, N-[2-(2-carbamoylpyrrolidin-1-yl)-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide exemplifies the intricate interplay between structure and function in chemical compounds, revealing the exciting possibilities that lie ahead in scientific exploration.

Synonyms
5-oxoprolylhistidylprolinamide
DTXSID30860316
RefChem:1073214
DTXCID70204018
TRH
Thyrotropin alfa
C16H22N6O4
1-{3-imidazol-5-yl-2-[(5-oxopyrrolidin-2-yl)carbonylamino]propanoyl}pyrrolidin e-2-carboxamide
194100-83-9
Phe2TRH
pyro-Glu-His-Pro-NH2
SCHEMBL8364920
SCHEMBL10087946
BDBM86214
XNSAINXGIQZQOO-UHFFFAOYSA-N
HMS3264O18
HMS3755A13
HMS5083I14
Pharmakon1600-01506101
PTR-4011-V
PTR-4011
24305-27-9 net
CAS_32281
NSC_32281
NSC760113
AKOS024284364
CCG-213612
SMP2_000152
NCGC00166322-01
NCGC00166322-02
ST075200
DB-046389
AB01563143_01
L001154
BRD-A16997652-001-02-3
Thyrotropin Releasing Hormone (TRH) (Human, Ovine, Porcine, Rat)
Thyrotropin Releasing Hormone (TRH) (Human, Ovine, Porcine, Rat)
N-[2-(2-carbamoylpyrrolidin-1-yl)-1-(1H-imidazol-5-ylmethyl)-2-oxo-ethyl]-5-oxo-pyrrolidine-2-carboxamide
Pyr-His-Pro-NH2 * H2O, Protirelin, Lopremone, Rifathyroin, Thyroliberin, Thypinone, Synthetic TRH, TSH-releasing factor
Pyr-His-Pro-NH2, Protirelin, Lopremone, Rifathyroin, Thyroliberin, Thypinone, Synthetic TRH, TSH-releasing factor