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Duloxetine

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Identification
Molecular formula
C18H19NO2
CAS number
116539-59-4
IUPAC name
N-[2-[3-(dimethylamino)propoxy]phenyl]-3-phenyl-prop-2-enamide
State
State

At room temperature, duloxetine remains a solid.

Melting point (Celsius)
177.50
Melting point (Kelvin)
450.65
Boiling point (Celsius)
539.90
Boiling point (Kelvin)
813.05
General information
Molecular weight
297.41g/mol
Molar mass
297.4100g/mol
Density
1.3100g/cm3
Appearence

Duloxetine is typically found as a crystalline solid. It is faintly beige to yellowish in color and exists as a powder form when in a pure state.

Comment on solubility

Solubility of N-[2-[3-(dimethylamino)propoxy]phenyl]-3-phenyl-prop-2-enamide

The solubility of N-[2-[3-(dimethylamino)propoxy]phenyl]-3-phenyl-prop-2-enamide can be quite fascinating due to its unique molecular structure. Several factors influence its solubility:

  • Polarity: As a compound that contains both hydrophobic (aromatic) and hydrophilic (amine and ether) groups, its solubility in water may be limited. Generally, compounds with significant hydrophobic character show reduced solubility in aqueous environments.
  • Solvent Interaction: This compound is more likely to dissolve in organic solvents such as methanol, ethanol, or DMSO due to a better match in polarity. The presence of non-polar phenyl groups aids in enhancing solubility in these organic solvents.
  • Temperature Dependence: Solubility can vary significantly with temperature. Increasing temperature often enhances the solubility of organic compounds.
  • pH Influence: The amine group may change its protonation state based on the pH of the solution, possibly affecting its interaction with solvents and overall solubility.

In summary, while N-[2-[3-(dimethylamino)propoxy]phenyl]-3-phenyl-prop-2-enamide exhibits limited solubility in water, it can show greater solubility in various organic solvents. Understanding these nuances can help in predicting its behavior in different environments.

Interesting facts

Interesting Facts about N-[2-[3-(dimethylamino)propoxy]phenyl]-3-phenyl-prop-2-enamide

This compound, known for its unique structure and diverse applications, is a member of the class of organic compounds characterized by an aromatic amide. Here are some engaging details:

  • Pharmaceutical Potential: With its complex structure, this compound has shown promise in the pharmaceutical industry, particularly in the development of new drugs targeting various disorders.
  • Structure-Activity Relationship: The presence of the dimethylamino group is crucial as it can influence the compound's biological activity, potency, and selectivity for specific targets in the body.
  • Research Interest: Chemists are actively researching this compound due to its potential to be a lead compound in medicinal chemistry, allowing for modifications to enhance efficacy.
  • Reaction Pathways: The synthesis of this compound involves multiple reaction pathways, including amide formation and alkylation, fascinating students and researchers alike.

Applications in Various Fields

Beyond pharmaceuticals, N-[2-[3-(dimethylamino)propoxy]phenyl]-3-phenyl-prop-2-enamide serves multiple roles:

  • Material Science: Its properties make it suitable for certain polymer formulations.
  • Research in Neuroscience: Certain derivatives of this compound are investigated for their effects on neurotransmitter systems.
  • Biotechnology: Exploration of its use in biosensors and drug delivery mechanisms is underway.

As the research surrounding this compound continues to evolve, it holds the promise of contributing significantly to advancements in medicinal chemistry and beyond. “Chemical compounds are like stories waiting to be told,” and this compound is certainly no exception!