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Clonidine

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Identification
Molecular formula
C12H16ClN3
CAS number
4205-91-8
IUPAC name
N'-[2-(3-methoxyphenoxy)propyl]-2-(m-tolyl)acetamidine
State
State

At room temperature, clonidine is in a solid state, specifically as a crystalline powder. The compound is stable under normal conditions and does not readily dissolve in water.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
437.40
Boiling point (Kelvin)
710.50
General information
Molecular weight
230.34g/mol
Molar mass
230.3370g/mol
Density
1.2390g/cm3
Appearence

Clonidine typically appears as a white or off-white crystalline powder. It may also appear as a solid in its pure form. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility Characteristics of N'-[2-(3-Methoxyphenoxy)propyl]-2-(m-Tolyl)acetamidine

The solubility of N'-[2-(3-methoxyphenoxy)propyl]-2-(m-tolyl)acetamidine is influenced by its chemical structure and the functional groups present. Its solubility can vary considerably based on the solvent used. Here are some key points to consider:

  • Hydrophobic vs. Hydrophilic Nature: The presence of both hydrophobic aromatic rings and hydrophilic amine functionalities suggests that the compound may exhibit _limited solubility_ in polar solvents while being more soluble in non-polar organic solvents.
  • Solvent Compatibility: Common organic solvents such as methanol, ethanol, and dimethyl sulfoxide (DMSO) may enhance solubility due to their ability to interact with the compound.
  • Temperature Effects: Solubility often increases with temperature; therefore, assessing solubility at different temperatures may provide more insight into its behavior in various conditions.

As stated in chemical literature, “_The degree of solubility is inherently tied to the intricate balance of intermolecular forces_.” In practice, conducting solubility tests in a range of solvents is critical for determining the optimal conditions for applications involving this compound.

In summary, understanding the solubility profile of N'-[2-(3-methoxyphenoxy)propyl]-2-(m-tolyl)acetamidine not only aids in its practical use but also serves as a foundation for future research and development in related chemical fields.

Interesting facts

Interesting Facts about N'-[2-(3-methoxyphenoxy)propyl]-2-(m-tolyl)acetamidine

N'-[2-(3-methoxyphenoxy)propyl]-2-(m-tolyl)acetamidine is a fascinating compound with a range of applications in chemical research and medicinal chemistry. Here are some intriguing insights into this compound:

  • Pharmacological Potential: This compound contains an acetamidine group, which has been studied for its potential in antibiotic and anti-inflammatory activities. Its unique structure may offer novel therapeutic avenues.
  • Structure-Activity Relationship (SAR): The presence of both a methoxyphenoxy and a m-tolyl group makes it particularly interesting from an SAR perspective, as small changes in these substituents can significantly affect biological activity.
  • Versatile Intermediary: It can serve as an intermediary in organic synthesis, especially in creating more complex molecules, thereby expanding the toolbox available to chemists in drug development.
  • Applications in Material Science: Beyond its pharmacological implications, compounds with similar structures are often explored in material science for their ability to form conductive polymers or as stabilizers in various applications.
  • Research Insights: Research has shown that compounds like this one may interact with specific biological targets in ways that are not fully understood, highlighting the need for ongoing studies to uncover their mechanisms of action.

As researchers continue to explore the potential of N'-[2-(3-methoxyphenoxy)propyl]-2-(m-tolyl)acetamidine, its unique properties and versatility ensure that it will remain a subject of interest in both medicinal chemistry and materials science. In the words of a renowned chemist, "Every compound tells a story; it's our job to discover it."

Synonyms
xylamidine
6443-50-1
UNII-NY0PC84NZK
NY0PC84NZK
Benzeneethanimidamide, N-(2-(3-methoxyphenoxy)propyl)-3-methyl-
N-(2-(3-methoxyphenoxy)propyl)-m-tolylacetamidine tosylate
Benzeneethanimidamide, N-[2-(3-methoxyphenoxy)propyl]-3-methyl-
N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE
N'-[2-(3-methoxyphenoxy)propyl]-2-(3-methylphenyl)ethanimidamide
SCHEMBL2107805
CHEMBL2110630
DTXSID90863843
PDSP1_001352
PDSP2_001336
AKOS040754478
HY-101480
Q8045338
N-(2-(3-Methoxyphenoxy)propyl)-2-(m-tolyl)acetimidamide