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Tacrine

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Identification
Molecular formula
C23H28N2O2
CAS number
321-64-2
IUPAC name
N-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroacridin-9-amine
State
State
Tacrine is typically available as a crystalline solid at room temperature.
Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
524.90
Boiling point (Kelvin)
798.05
General information
Molecular weight
348.49g/mol
Molar mass
348.4310g/mol
Density
1.2600g/cm3
Appearence

Tacrine typically appears as an off-white to pale yellow crystalline powder.

Comment on solubility

Solubility of N-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroacridin-9-amine

The solubility of N-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroacridin-9-amine can be influenced by several factors due to its unique structure. Understanding its solubility characteristics is crucial for its application in various chemical contexts. Here are some key points to consider:

  • Solvent Interaction: This compound is likely to have variable solubility across different solvents. Its aromatic structure may increase solubility in organic solvents, such as ethanol and dimethyl sulfoxide (DMSO).
  • Polarity: The presence of the dimethoxyphenyl group suggests that it may have polar characteristics, possibly enhancing its solubility in polar solvents.
  • Temperature Dependency: Solubility often increases with temperature. Thus, heating might improve the dissolution of this compound.
  • pH Sensitivity: Depending on the functional groups, solubility can be affected by the pH of the solvent. Monitoring and adjusting pH could potentially optimize solubility.

In general, the solubility of complex amines like N-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroacridin-9-amine is a multifaceted issue that requires careful consideration of the solvent system used. As noted, *“The right environment can make all the difference in whether a compound can dissolve effectively.”* Understanding these nuances can help in the successful formulation and application of this compound in various scientific fields.

Interesting facts

Interesting Facts about N-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroacridin-9-amine

N-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroacridin-9-amine is a fascinating compound with diverse implications in the field of medicine and neuroscience. Here are some compelling points to consider:

  • Potential Therapeutic Applications: This compound has garnered attention for its potential role in treating neurodegenerative diseases, particularly Alzheimer's disease. Its structural components suggest it may influence acetylcholine levels, a key neurotransmitter involved in cognition.
  • Unique Structure: The tetrahydroacridine backbone provides a robust framework that enables various functional modifications. This characteristic makes it a key candidate for drug development, allowing for synthesis variations that can enhance its pharmacological properties.
  • Design Inspiration: The compound embodies creativity in drug synthesis. Scientists are continually inspired by its unique combination of aromatic and aliphatic moieties, facilitating studies in structure-activity relationships (SAR) that explore how small alterations can lead to significant changes in biological activity.
  • Research Significance: Various studies have been conducted to assess its efficacy. Preclinical models have suggested this compound could improve memory retention, raising intrigue in academic and pharmaceutical circles alike.

As the field of medicinal chemistry advances, compounds like N-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroacridin-9-amine are paving the way for new understanding and treatments in neuroscience. It is an exciting time to explore and unravel the potential buried within such compounds!

Synonyms
5782-95-6
ACRIDINE, 1,2,3,4-TETRAHYDRO-9-(2-(3,4-DIMETHOXYPHENYL)ETHYL)AMINO-
BRN 0445700
4-(2-(3,4,-Dimethoxyphenyl)ethyl)amino-2,3-tetramethylenequinoline
Acridine, 9-(2-(3,4-dimethoxyphenyl)ethyl)amino-1,2,3,4-tetrahydro-
Phenethylamine, 3,4-dimethoxy-N-(1,2,3,4-tetrahydro-9-acridinyl)-
CHEMBL3185768
DTXSID70206537
BDBM199196
KUC109856N
KSC-28-25-1
N-(3,4-Dimethoxyphenethyl)-1,2,3,4-tetrahydroacridin-9-amine (11a)